Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Metallothionein and brain inflammation

(2011) Yasmina Manso et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Chemistry and biology of mammalian metallothioneins

(2011) Milan Vašák et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Redox biochemistry of mammalian metallothioneins

(2011) Wolfgang Maret   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

(2011) Vello Tõugu et al.   Metallomics

Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation

(2010) Jiyeon Ock et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin

(2010) Ana Martinho et al.   FEBS Journal

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Fibrillar Amyloid- -Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease

(2010) A. Jana et al.   JOURNAL OF NEUROSCIENCE

The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons

(2010) Roger S. Chung et al.   PLoS One

Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways

(2009) Y.K.J. Leung et al.   EXPERIMENTAL NEUROLOGY

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides

(2009) Christopher M. Davenport et al.   JOURNAL OF NEUROCHEMISTRY

Intraneuronal signaling pathways of metallothionein

(2009) Johanne Wirenfeldt Asmussen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury

(2009) R. S. Chung et al.   NEUROTOXICITY RESEARCH

Redefining the Role of Metallothionein within the Injured Brain

(2008) Roger S. Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

(2008) Gabriele Meloni et al.   Nature Chemical Biology