Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

SHANK1 Deletions in Males with Autism Spectrum Disorder

(2012) Daisuke Sato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

(2012) Claire S. Leblond et al.   PLoS Genetics

RETRACTED: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism

(2011) M Ali Bangash et al.   CELL

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

(2011) Andreas M Grabrucker et al.   EMBO JOURNAL

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

(2011) Andreas M Grabrucker et al.   Molecular Neurodegeneration

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Infantile zinc deficiency: Association with autism spectrum disorders

(2011) Hiroshi Yasuda et al.   Scientific Reports

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Level of Trace Elements (Copper, Zinc, Magnesium and Selenium) and Toxic Elements (Lead and Mercury) in the Hair and Nail of Children with Autism

(2010) Malarveni Damodaran Lakshmi Priya et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Syndromes associated with nutritional deficiency and excess

(2010) Melinda Jen et al.   CLINICS IN DERMATOLOGY

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

(2010) Simone Berkel et al.   NATURE GENETICS

The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders

(2009) Scott Faber et al.   BIOMARKERS

Synaptogenesis of hippocampal neurons in primary cell culture

(2009) Andreas Grabrucker et al.   CELL AND TISSUE RESEARCH

Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors

(2009) Akihiro Koumura et al.   NEUROSCIENCE LETTERS

Zinc: The brain's dark horse

(2009) Byron K.Y. Bitanihirwe et al.   SYNAPSE

Novel de novo SHANK3 mutation in autistic patients

(2008) Julie Gauthier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Nutritional and Environmental Approaches to Preventing and Treating Autism and Attention Deficit Hyperactivity Disorder (ADHD): A Review

(2008) Luke T. Curtis et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE