Cancer stem cell drugs target K-ras signaling in a stemness context

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers

(2015) Arafath K. Najumudeen et al.   BIOCHEMISTRY

Ras nanoclusters: Versatile lipid-based signaling platforms

(2015) Yong Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A New View of Ras Isoforms in Cancers

(2015) R. Nussinov et al.   CANCER RESEARCH

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

(2015) Man-Tzu Wang et al.   CELL

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

(2015) R. Nussinov et al.   MOLECULAR CANCER RESEARCH

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

(2015) Frederick D. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

(2015) Maja Šolman et al.   eLife

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT

(2014) Fraser P. Coxon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering

(2014) Camilo Guzmán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

(2014) Nicholas Ariotti et al.   JOURNAL OF CELL BIOLOGY

Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice

(2014) Wolfgang Boehmerle et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

TCGA-Assembler: open-source software for retrieving and processing TCGA data

(2014) Yitan Zhu et al.   NATURE METHODS

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

(2014) E Lemieux et al.   ONCOGENE

Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

(2013) Shuang Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters

(2013) Yong Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

(2013) Qing Li et al.   NATURE

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

ESTOOLS Data@Hand: human stem cell gene expression resource

(2013) Lingjia Kong et al.   NATURE METHODS

Mechanisms and models of somatic cell reprogramming

(2013) Yosef Buganim et al.   NATURE REVIEWS GENETICS

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

(2013) Arafath Kaja Najumudeen et al.   PLoS One

The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration

(2013) Natasha Baker et al.   Stem Cell Research & Therapy

Polyether ionophores—promising bioactive molecules for cancer therapy

(2012) Adam Huczyński   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EMT in breast cancer stem cell generation

(2012) Stéphane Ansieau   CANCER LETTERS

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

(2012) Eleftherios Sachlos et al.   CELL

Design and Application of In Vivo FRET Biosensors to Identify Protein Prenylation and Nanoclustering Inhibitors

(2012) Monika Köhnke et al.   CHEMISTRY & BIOLOGY

Structure-Based Reassessment of the Caveolin Signaling Model: Do Caveolae Regulate Signaling through Caveolin-Protein Interactions?

(2012) Brett M. Collins et al.   DEVELOPMENTAL CELL

The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase

(2012) Alex M. Sykes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins

(2012) Kwang-jin Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salinomycin as a Drug for Targeting Human Cancer Stem Cells

(2012) Cord Naujokat et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Liberation of Embryonic Stem Cells

(2011) Kathryn Blair et al.   PLoS Genetics

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor

(2010) Roberta Riccioni et al.   BLOOD CELLS MOLECULES AND DISEASES

An N-Terminal Polybasic Motif of G q Is Required for Signaling and Influences Membrane Nanodomain Distribution

(2010) M. Crouthamel et al.   MOLECULAR PHARMACOLOGY

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output

(2010) Barak Rotblat et al.   PLoS One

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells

(2009) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

(2009) Michele Bastiani et al.   JOURNAL OF CELL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

A novel switch region regulates H-ras membrane orientation and signal output

(2008) Daniel Abankwa et al.   EMBO JOURNAL

Evolutionary analysis and molecular dissection of caveola biogenesis

(2008) M. Kirkham et al.   JOURNAL OF CELL SCIENCE

Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion

(2008) M. P. Quinlan et al.   MOLECULAR AND CELLULAR BIOLOGY