Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

‘Latent drivers’ expand the cancer mutational landscape

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

(2015) Mohammad T. Mazhab-Jafari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

(2015) Xiaolin Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP-Dependent K-Ras Dimerization

(2015) Serena Muratcioglu et al.   STRUCTURE

A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction

(2014) Kari Kopra et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering

(2014) Camilo Guzmán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

(2014) Camilo Guzmán et al.   PLoS One

H-Ras forms dimers on membrane surfaces via a protein-protein interface

(2014) W.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

(2013) Arafath Kaja Najumudeen et al.   PLoS One

Aggregation of Lipid-Anchored Full-Length H-Ras in Lipid Bilayers: Simulations with the MARTINI Force Field

(2013) Hualin Li et al.   PLoS One

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

(2013) X. Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Ras Forms Dimers at POPC Membranes

(2012) Jörn Güldenhaupt et al.   BIOPHYSICAL JOURNAL

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Design and Application of In Vivo FRET Biosensors to Identify Protein Prenylation and Nanoclustering Inhibitors

(2012) Monika Köhnke et al.   CHEMISTRY & BIOLOGY

Raf Inhibitors Target Ras Spatiotemporal Dynamics

(2012) Kwang-jin Cho et al.   CURRENT BIOLOGY

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

(2012) Shobhna Kapoor et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

(2012) I. C. Cirstea et al.   HUMAN MOLECULAR GENETICS

Nonsteroidal Anti-inflammatory Drugs Alter the Spatiotemporal Organization of Ras Proteins on the Plasma Membrane

(2012) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane mechanisms for signal transduction: The coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complexes

(2012) Akihiro Kusumi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of Ras membrane organization and signaling: Ras on a rocker

(2011) Daniel Abankwa et al.   CELL CYCLE

Revealing conformational substates of lipidated N-Ras protein by pressure modulation

(2011) S. Kapoor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine

(2010) G Smith et al.   BRITISH JOURNAL OF CANCER

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

(2010) Lothar Gremer et al.   HUMAN MUTATION

H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output

(2010) Barak Rotblat et al.   PLoS One

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A restricted spectrum of NRAS mutations causes Noonan syndrome

(2009) Ion C Cirstea et al.   NATURE GENETICS

Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity

(2008) Debanjan Goswami et al.   CELL

A novel switch region regulates H-ras membrane orientation and signal output

(2008) Daniel Abankwa et al.   EMBO JOURNAL

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function

(2008) S. J. Plowman et al.   MOLECULAR AND CELLULAR BIOLOGY

Mapping the Nucleotide and Isoform-Dependent Structural and Dynamical Features of Ras Proteins

(2008) Alemayehu A. Gorfe et al.   STRUCTURE