Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions

(2013) J. Wang et al.   BLOOD

Clonal architecture of chronic myelomonocytic leukemias

(2013) R. Itzykson et al.   BLOOD

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

ConstitutionalNRASmutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia

(2012) Lilia Kraoua et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Targeting oncogenic Ras signaling in hematologic malignancies

(2012) A. F. Ward et al.   BLOOD

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

(2012) Lara Rossi et al.   Cell Stem Cell

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

(2010) Q. Li et al.   BLOOD

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia

(2010) J. Wang et al.   BLOOD

A Flt3- and Ras-Dependent Pathway Primes B Cell Development by Inducing a State of IL-7 Responsiveness

(2010) Lin-Xi Li et al.   JOURNAL OF IMMUNOLOGY

Germ-line mutation of theNRASgene may be responsible for the development of juvenile myelomonocytic leukaemia

(2009) Paola De Filippi et al.   BRITISH JOURNAL OF HAEMATOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

(2009) Amit J Sabnis et al.   PLOS BIOLOGY

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

(2008) Nikesh Kotecha et al.   CANCER CELL

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS