标题
Cancer stem cell drugs target K-ras signaling in a stemness context
作者
关键词
-
出版物
ONCOGENE
Volume 35, Issue 40, Pages 5248-5262
出版商
Springer Nature
发表日期
2016-03-14
DOI
10.1038/onc.2016.59
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers
- (2015) Arafath K. Najumudeen et al. BIOCHEMISTRY
- Ras nanoclusters: Versatile lipid-based signaling platforms
- (2015) Yong Zhou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- A New View of Ras Isoforms in Cancers
- (2015) R. Nussinov et al. CANCER RESEARCH
- K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling
- (2015) Man-Tzu Wang et al. CELL
- The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
- (2015) R. Nussinov et al. MOLECULAR CANCER RESEARCH
- K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif
- (2015) Frederick D. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation
- (2015) Maja Šolman et al. eLife
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT
- (2014) Fraser P. Coxon et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering
- (2014) Camilo Guzmán et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling
- (2014) Nicholas Ariotti et al. JOURNAL OF CELL BIOLOGY
- Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice
- (2014) Wolfgang Boehmerle et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition
- (2014) Laetitia Seguin et al. NATURE CELL BIOLOGY
- Small-molecule modulation of Ras signaling
- (2014) Jochen Spiegel et al. Nature Chemical Biology
- TCGA-Assembler: open-source software for retrieving and processing TCGA data
- (2014) Yitan Zhu et al. NATURE METHODS
- Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
- (2014) E Lemieux et al. ONCOGENE
- Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities
- (2013) Shuang Zhou et al. CURRENT MEDICINAL CHEMISTRY
- Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters
- (2013) Yong Zhou et al. MOLECULAR AND CELLULAR BIOLOGY
- Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
- (2013) Qing Li et al. NATURE
- Cancer stem cells: The challenges ahead
- (2013) Jan Paul Medema NATURE CELL BIOLOGY
- ESTOOLS Data@Hand: human stem cell gene expression resource
- (2013) Lingjia Kong et al. NATURE METHODS
- Mechanisms and models of somatic cell reprogramming
- (2013) Yosef Buganim et al. NATURE REVIEWS GENETICS
- Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins
- (2013) Arafath Kaja Najumudeen et al. PLoS One
- The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration
- (2013) Natasha Baker et al. Stem Cell Research & Therapy
- Polyether ionophores—promising bioactive molecules for cancer therapy
- (2012) Adam Huczyński BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- EMT in breast cancer stem cell generation
- (2012) Stéphane Ansieau CANCER LETTERS
- Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
- (2012) Eleftherios Sachlos et al. CELL
- Design and Application of In Vivo FRET Biosensors to Identify Protein Prenylation and Nanoclustering Inhibitors
- (2012) Monika Köhnke et al. CHEMISTRY & BIOLOGY
- Structure-Based Reassessment of the Caveolin Signaling Model: Do Caveolae Regulate Signaling through Caveolin-Protein Interactions?
- (2012) Brett M. Collins et al. DEVELOPMENTAL CELL
- The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase
- (2012) Alex M. Sykes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins
- (2012) Kwang-jin Cho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Salinomycin as a Drug for Targeting Human Cancer Stem Cells
- (2012) Cord Naujokat et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
- (2011) Bidisha Sinha et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine
- (2011) Gregory D. Fairn et al. JOURNAL OF CELL BIOLOGY
- Stem cell gene expression programs influence clinical outcome in human leukemia
- (2011) Kolja Eppert et al. NATURE MEDICINE
- Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- (2011) Desheng Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Liberation of Embryonic Stem Cells
- (2011) Kathryn Blair et al. PLoS Genetics
- The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor
- (2010) Roberta Riccioni et al. BLOOD CELLS MOLECULES AND DISEASES
- An N-Terminal Polybasic Motif of G q Is Required for Signaling and Influences Membrane Nanodomain Distribution
- (2010) M. Crouthamel et al. MOLECULAR PHARMACOLOGY
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output
- (2010) Barak Rotblat et al. PLoS One
- Ras membrane orientation and nanodomain localization generate isoform diversity
- (2010) D. Abankwa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers
- (2009) Agnieszka K. Witkiewicz et al. AMERICAN JOURNAL OF PATHOLOGY
- Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells
- (2009) Dominik Fuchs et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
- (2009) Piyush B. Gupta et al. CELL
- MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes
- (2009) Michele Bastiani et al. JOURNAL OF CELL BIOLOGY
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function
- (2008) Michelle M. Hill et al. CELL
- A novel switch region regulates H-ras membrane orientation and signal output
- (2008) Daniel Abankwa et al. EMBO JOURNAL
- Evolutionary analysis and molecular dissection of caveola biogenesis
- (2008) M. Kirkham et al. JOURNAL OF CELL SCIENCE
- Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion
- (2008) M. P. Quinlan et al. MOLECULAR AND CELLULAR BIOLOGY
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