Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of RAS/β-catenin interactions

(2013) Eva Zeller et al.   ARCHIVES OF TOXICOLOGY

A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

(2013) Roland Rad et al.   CANCER CELL

APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression

(2013) Chenhui Wang et al.   DEVELOPMENTAL BIOLOGY

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

BRAF as a Target for Cancer Therapy

(2012) Rodrigo Dienstmann et al.   Anti-Cancer Agents in Medicinal Chemistry

Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling

(2012) D. Horst et al.   CANCER RESEARCH

TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers

(2012) Anurag Singh et al.   CELL

Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling

(2012) Kyle D. Proffitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

(2012) S Cagnol et al.   ONCOGENE

Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation

(2012) Pavel Krejci et al.   PLoS One

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

(2010) Moritz Bennecke et al.   CANCER CELL

Targets of Raf in tumorigenesis

(2010) T. S. Niault et al.   CARCINOGENESIS

SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein

(2010) Mélanie Simoneau et al.   CELLULAR SIGNALLING

New Strategies in Colorectal Cancer: Biomarkers of Response to Epidermal Growth Factor Receptor Monoclonal Antibodies and Potential Therapeutic Targets in Phosphoinositide 3-Kinase and Mitogen-Activated Protein Kinase Pathways

(2010) A. Dasari et al.   CLINICAL CANCER RESEARCH

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation ofp16INK4a

(2010) Linda A. S. Carragher et al.   EMBO Molecular Medicine

Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas

(2010) Antònia Obrador-Hevia et al.   JOURNAL OF PATHOLOGY

Nuclear β-catenin expression and Wnt signalling: in defence of the dogma

(2010) Riccardo Fodde et al.   JOURNAL OF PATHOLOGY

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

(2010) Sébastien Bergeron et al.   Molecular Cancer

ERK activation drives intestinal tumorigenesis in Apcmin/+ mice

(2010) Sung Hee Lee et al.   NATURE MEDICINE

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

(2010) Marie-Josée Langlois et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss

(2009) Reid A. Phelps et al.   CELL

Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

(2009) Étienne Lemieux et al.   INTERNATIONAL JOURNAL OF CANCER

Mutated K-rasAsp12promotes tumourigenesis inApcMinmice more in the large than the small intestines, with synergistic effects between K-rasandWntpathways

(2009) Feijun Luo et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

(2008) Laure Voisin et al.   BMC CANCER

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

(2008) Joe W. Ramos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Genome-Wide Screen for  -Catenin Binding Sites Identifies a Downstream Enhancer Element That Controls c-Myc Gene Expression

(2008) G. S. Yochum et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis

(2007) Mandayam O. Nandan et al.   GASTROENTEROLOGY