The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase

Amyloid-β Peptides Stimulate the Expression of the p75NTR Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice

(2017) Balu Chakravarthy et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Amyloid Accumulation in the Hippocampus of SAMP8 Mice

(2017) Jaume del Valle et al.   JOURNAL OF ALZHEIMERS DISEASE

Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

(2012) Sune Skeldal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling

(2011) Reddy P. Kommaddi et al.   FASEB JOURNAL

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the APP GxxxG Motif

(2010) Lisa-Marie Munter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

(2010) C. Ceni et al.   JOURNAL OF CELL SCIENCE

Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTRinteraction

(2009) Joanna Fombonne et al.   ANNALS OF NEUROLOGY

Membrane topology of gp41 and amyloid precursor protein: Interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment

(2009) Concepción Abad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

(2009) M. Vilar et al.   JOURNAL OF CELL SCIENCE

Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin

(2009) Dan Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Transmembrane Structures of Amyloid Precursor Protein Dimer Predicted by Replica-Exchange Molecular Dynamics Simulations

(2009) Naoyuki Miyashita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

(2009) Marçal Vilar et al.   NEURON

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

(2008) Paul M Gorman et al.   BMC NEUROSCIENCE

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel switch region regulates H-ras membrane orientation and signal output

(2008) Daniel Abankwa et al.   EMBO JOURNAL

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

(2008) Pascal Kienlen-Campard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by γ-secretase

(2007) Clare K. Underwood et al.   MOLECULAR AND CELLULAR NEUROSCIENCE