Fluorescent Probes for G-Quadruplex Structures

Luminescent G-quadruplex Probes

(2012) Dik-Lung Ma et al.   CURRENT PHARMACEUTICAL DESIGN

Experimental approaches to identify cellular G-quadruplex structures and functions

(2012) Marco Di Antonio et al.   METHODS

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

Interaction of human telomeric DNA with N- methyl mesoporphyrin IX

(2012) John M. Nicoludis et al.   NUCLEIC ACIDS RESEARCH

Label-free detection of nucleic acids by turn-on and turn-off G-quadruplex-mediated fluorescence

(2011) Jiangtao Ren et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

8-Vinyl-2′-deoxyguanosine as a Fluorescent 2′-Deoxyguanosine Mimic for Investigating DNA Hybridization and Topology

(2011) André Nadler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-phenyl-carbazole-based two-photon fluorescent probes: Strong sequence dependence of the duplex vs quadruplex selectivity

(2011) B. Dumat et al.   BIOCHIMIE

The stability of intramolecular DNA G-quadruplexes compared with other macromolecules

(2011) Andrew N. Lane   BIOCHIMIE

Interaction of G-Quadruplexes with Nonintercalating Duplex-DNA Minor Groove Binding Ligands

(2011) Akash K. Jain et al.   BIOCONJUGATE CHEMISTRY

A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA

(2011) Ha Na Kim et al.   BIOMATERIALS

Effects of Site-Specific Guanine C8-Modifications on an Intramolecular DNA G-Quadruplex

(2011) Christopher Jacques Lech et al.   BIOPHYSICAL JOURNAL

Docking on the DNA G-quadruplex: A molecular electrostatic potential study

(2011) Juan Antonio Mondragón-Sánchez et al.   BIOPOLYMERS

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Fluorescence Properties of 8-(2-Pyridyl)guanine “2PyG” as Compared to 2-Aminopurine in DNA

(2011) Anaëlle Dumas et al.   CHEMBIOCHEM

Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex

(2011) Yu-Jing Lu et al.   CHEMICAL COMMUNICATIONS

Crystal violet as a G-quadruplex-selective probe for sensitive amperometric sensing of lead

(2011) Feng Li et al.   CHEMICAL COMMUNICATIONS

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

(2011) Shizuka Nakayama et al.   CHEMICAL COMMUNICATIONS

Conformational changes of non-B DNA

(2011) Jungkweon Choi et al.   CHEMICAL SOCIETY REVIEWS

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

Phosphorescent heavy-metal complexes for bioimaging

(2011) Qiang Zhao et al.   CHEMICAL SOCIETY REVIEWS

Site-Specific Control of N7-Metal Coordination in DNA by a Fluorescent Purine Derivative

(2011) Anaëlle Dumas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Following G-quadruplex formation by its intrinsic fluorescence

(2011) Nguyen Thuan Dao et al.   FEBS LETTERS

Contribution of Telomere G-Quadruplex Stabilization to the Inhibition of Telomerase-Mediated Telomere Extension by Chemical Ligands

(2011) Chang-yue Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting the Strand Folding Orientation and Formation of G-Quadruplexes in Single- and Double-Stranded Nucleic Acids by Ligand-Induced Photocleavage Footprinting

(2011) Ke-wei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emissive RNA Alphabet

(2011) Dongwon Shin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prospects for Riboswitch Discovery and Analysis

(2011) Ronald R. Breaker   MOLECULAR CELL

Is telomerase a viable target in cancer?

(2011) C.M. Buseman et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

(2011) Jasmine S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Highly fluorescent guanosine mimics for folding and energy transfer studies

(2011) Anaëlle Dumas et al.   NUCLEIC ACIDS RESEARCH

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

(2011) J. Eddy et al.   NUCLEIC ACIDS RESEARCH

Polymorphism and resolution of oncogene promoter quadruplex-forming sequences

(2011) M. Clarke Miller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

G-Quadruplex formation of deoxyguanosine in the presence of alkaline earth metal ions studied by electrospray ionization mass spectrometry

(2011) M. Sravani et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

G-Quadruplex-Modulated Fluorescence Detection of Potassium in the Presence of a 3500-Fold Excess of Sodium Ions

(2010) Haixia Qin et al.   ANALYTICAL CHEMISTRY

Parallel G-Quadruplex-Specific Fluorescent Probe for Monitoring DNA Structural Changes and Label-Free Detection of Potassium Ion

(2010) Tao Li et al.   ANALYTICAL CHEMISTRY

DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic Reaction for Sensing G-Quadruplex Formation

(2010) Kamel Meguellati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interaction of Metal Complexes with G-Quadruplex DNA

(2010) Savvas N. Georgiades et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

Specific High-Affinity Binding of Thiazole Orange to Triplex and G-Quadruplex DNA

(2010) Irit Lubitz et al.   BIOCHEMISTRY

pH-Mediated Fluorescence and G-Quadruplex Binding of Amido Phthalocyanines

(2010) Jawad Alzeer et al.   BIOCHEMISTRY

Interaction of [Ru(bpy)2(dppz)]2+ with human telomeric DNA: Preferential binding to G-quadruplexes over i-motif

(2010) Shuo Shi et al.   BIOCHIMIE

Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes

(2010) Girish Koripelly et al.   BIOCONJUGATE CHEMISTRY

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

RecQ family helicases in genome stability: Lessons from gene disruption studies in DT40 cells

(2010) Masayuki Seki et al.   CELL CYCLE

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

(2010) Arivazhagan Rajendran et al.   CHEMICAL COMMUNICATIONS

Structure-Based Design of Platinum(II) Complexes as c-myc Oncogene Down-Regulators and Luminescent Probes for G-Quadruplex DNA

(2010) Ping Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular “light switch” for G-quadruplexes and i-motif of human telomeric DNA: [Ru(phen)2(dppz)]2+

(2010) Shuo Shi et al.   DALTON TRANSACTIONS

Mono and Trimethine Cyanines Cyan 40 and Cyan 2 as Probes for Highly Selective Fluorescent Detection of Non-canonical DNA Structures

(2010) Vladyslava B. Kovalska et al.   JOURNAL OF FLUORESCENCE

Studies on synthesis, characterization, and G-quadruplex binding of Ru(II) complexes containing two dppz ligands

(2010) Jing Sun et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Excited-State Dynamics of dGMP Measured by Steady-State and Femtosecond Fluorescence Spectroscopy†

(2010) Francois-Alexandre Miannay et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Cation-Mediated Energy Transfer in G-Quadruplexes Revealed by an Internal Fluorescent Probe

(2010) Anaëlle Dumas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

ATR contributes to telomere maintenance in human cells

(2010) Gaëlle Pennarun et al.   NUCLEIC ACIDS RESEARCH

Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole

(2010) Masayuki Tera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(ii) complex with four-stranded DNA structures

(2010) Tom Wilson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent nucleic acid base analogues

(2010) L. Marcus Wilhelmsson   QUARTERLY REVIEWS OF BIOPHYSICS

Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

(2009) Peng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guanidinium-Modified Phthalocyanines as High-Affinity G-Quadruplex Fluorescent Probes and Transcriptional Regulators

(2009) Jawad Alzeer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescence of unmodified oligonucleotides: A tool to probe G-quadruplex DNA structure

(2009) Miguel Angel Mendez et al.   BIOPOLYMERS

ILPR repeats adopt diverse G-quadruplex conformations that determine insulin binding

(2009) Joseph D. Schonhoft et al.   BIOPOLYMERS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

An efficient two-step synthesis of metal-free phthalocyanines using a Zn(ii) template

(2009) Jawad Alzeer et al.   CHEMICAL COMMUNICATIONS

Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres

(2009) Qianfan Yang et al.   CHEMICAL COMMUNICATIONS

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRASG-quadruplexes

(2009) Alexandro Membrino et al.   CHEMICAL COMMUNICATIONS

pH-Modulated Watson–Crick Duplex–Quadruplex Equilibria of Guanine-Rich and Cytosine-Rich DNA Sequences 140 Base Pairs Upstream of thec-kitTranscription Initiation Site

(2009) Pavel Bucek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stabilization of G-Quadruplex DNA with Platinum(II) Schiff Base Complexes: Luminescent Probe and Down-Regulation of c-mycOncogene Expression

(2009) Peng Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeting G-Quadruplex DNA with Small Molecules

(2009) Nathan W. Luedtke   CHIMIA

NIR dyes for bioimaging applications

(2009) Jorge O Escobedo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

The i-Motif in thebcl-2P1 Promoter Forms an Unexpectedly Stable Structure with a Unique 8:5:7 Loop Folding Pattern

(2009) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

(2009) Zoë A. E. Waller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells

(2009) Martin R. Gill et al.   Nature Chemistry

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression

(2009) Himesh Fernando et al.   NUCLEIC ACIDS RESEARCH

An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in Neisseria gonorrhoeae

(2009) L. A. Cahoon et al.   SCIENCE

Conformational conversion of DNA G-quadruplex induced by a cationic porphyrin

(2009) Huijuan Zhang et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

Macrocyclic Hexaoxazoles as Sequence- and Mode-Selective G-Quadruplex Binders

(2008) Masayuki Tera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human Telomere Structure and Biology

(2008) Harold Riethman   Annual Review of Genomics and Human Genetics

Quadruplex DNA crystal structures and drug design

(2008) Stephen Neidle et al.   BIOCHIMIE

Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds

(2008) Daniel S. Pilch et al.   BIOCHIMIE

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

Characterization of two adenosine analogs as fluorescence probes in RNA

(2008) Ying Zhao et al.   BIOORGANIC CHEMISTRY

Label-Free Fluorescent Probing of G-Quadruplex Formation and Real-Time Monitoring of DNA Folding by a Quaternized Tetraphenylethene Salt with Aggregation-Induced Emission Characteristics

(2008) Yuning Hong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discrimination of G-Quadruplexes from Duplex and Single-Stranded DNAs with Fluorescence and Energy-Transfer Fluorescence Spectra of Crystal Violet

(2008) De-Ming Kong et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

Genomic Stability: FANCJ-Dependent G4 DNA Repair

(2008) Nancy Maizels   CURRENT BIOLOGY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Platinum(II) Complexes with Dipyridophenazine Ligands as Human Telomerase Inhibitors and Luminescent Probes for G-Quadruplex DNA

(2008) Dik-Lung Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany and the United States

(2008) Hisashi Takino et al.   MODERN PATHOLOGY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

A stress-responsive RNA switch regulates VEGFA expression

(2008) Partho Sarothi Ray et al.   NATURE

The functional response of upstream DNA to dynamic supercoiling in vivo

(2008) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A thermodynamic overview of naturally occurring intramolecular DNA quadruplexes

(2008) Niti Kumar et al.   NUCLEIC ACIDS RESEARCH

Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase II 

(2008) A. T. Jonstrup et al.   NUCLEIC ACIDS RESEARCH

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

(2008) K. Guo et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG

(2008) HuiJuan Zhang et al.   Science in China. Series B, Chemistry

The design of guanidinium-rich transporters and their internalization mechanisms

(2007) Paul A. Wender et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

Cellular nucleic acid binding protein binds G-rich single-stranded nucleic acids and may function as a nucleic acid chaperone

(2007) Pablo Armas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY