Bifunctional Amine-Squaramides: Powerful Hydrogen-Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions

Recent advances in asymmetric organocatalysis mediated by bifunctional amine–thioureas bearing multiple hydrogen-bonding donors

(2015) Xin Fang et al.   CHEMICAL COMMUNICATIONS

Corrigendum: Synthesis of Optically Active 2H-Thiopyrano[2,3-b]quinolines with Three Contiguous Stereocentersviaan Organocatalytic Asymmetric Tandem Michael-Henry Reaction

(2014) Lulu Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Conjugate Addition of Mercaptans to β-Substituted-β-Trifluoromethyl Oxazolidinone Enoates: Access to Chiral Trifluoromethylated Tertiary Thioethers and Thiols

(2014) Wenchao Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Rapid Asymmetric Synthesis of Highly Functionalized Indanolsviaa Michael/Henry Organocascade with Submol% Squaramide Catalyst Loadings

(2014) Charles C. J. Loh et al.   ADVANCED SYNTHESIS & CATALYSIS

Bifunctional Squaramide Catalysts with the Same Absolute Chirality for the Diastereodivergent Access to Densely Functionalised Cyclohexanes through Enantioselective Domino Reactions. Synthesis and Mechanistic Studies

(2014) Jose I. Martínez et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed Activation of Esters: A New Option for Asymmetric Domino Reactions

(2014) Pankaj Chauhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Functionalization/Asymmetric Michael Addition Cascade Enabled by Relay Catalysis: Metal Carbenoid Used for CC Bond Formation

(2014) Dian-Feng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric 1,2-Addition of α-Isothiocyanato Phosphonates: Synthesis of Chiral β-Hydroxy- or β-Amino-Substituted α-Amino Phosphonic Acid Derivatives

(2014) Yi-Ming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Tamura Cycloadditions

(2014) Francesco Manoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Enantioselective Friedel-Crafts Reaction of Naphthol with β,γ-Unsaturated α-Keto Esters

(2014) Hyun A Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Michael Addition of 1,3-Cyclohexanedione to Benzylidenemalonitriles

(2014) Chang Won Suh et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Chiral Bifunctional Squaramide-Catalyzed Highly Enantioselective Michael Addition of Allomaltol to β,γ-Unsaturated α-Ketoesters

(2014) Yunting Liu et al.   ChemCatChem

Asymmetric oxa-Michael-aza-Henry Cascade Reaction of 2-Hydroxyaryl-Substituted α-Amido Sulfones and Nitroolefins Mediated by Chiral Squaramides

(2014) Bo Zheng et al.   ChemCatChem

Organocatalytic asymmetric strategies to carbocyclic structures by γ-alkylation-annulation sequences

(2014) Bjarke S. Donslund et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of functionalized cyclohexanes bearing five stereocenters via a one-pot organocatalytic Michael–Michael–1,2-addition sequence

(2014) Pankaj Chauhan et al.   CHEMICAL COMMUNICATIONS

Chiral squaramide-catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1,3-dicarbonyls with Morita–Baylis–Hillman acetates of nitroalkenes

(2014) Divya K. Nair et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Carbon–Sulfur Bond-Forming Reactions

(2014) Pankaj Chauhan et al.   CHEMICAL REVIEWS

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Organocatalyzed Cascade Aza-Michael/Michael Addition for the Asymmetric Construction of Highly Functionalized Spiropyrazolone Tetrahydroquinolines

(2014) Jun-Hua Li et al.   Chemistry-An Asian Journal

Asymmetric Michael Addition/Intramolecular Cyclization Catalyzed by Bifunctional Tertiary Amine-Squaramides: Construction of Chiral 2-Amino-4H-chromene-3-Carbonitrile Derivatives

(2014) Yu Gao et al.   Chemistry-An Asian Journal

Enantioselective Construction of Functionalized Thiochromans via Squaramide-Catalyzed Asymmetric Cascade Sulfa-Michael/Michael Addition

(2014) Yi Yang et al.   CHINESE JOURNAL OF CHEMISTRY

Stereocontrolled Construction of the 3,4-Dihydrothiacarbazol-2(9H)-one Skeleton by Using Bifunctional Squaramide-Catalyzed Cascade Reactions

(2014) Shanren Chen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chiral Squaramide-Catalyzed Sulfa-Michael/Aldol Cascade for the Asymmetric Synthesis of Spirocyclic Tetrahydrothiophene Chromanone Derivatives

(2014) Bo-Liang Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Enantioselective Strecker Reaction of Imines Containing a Thiazole Moiety by Using a Cinchona-Based Squaramide Catalyst

(2014) Hai-Xiao He et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Access to Enantioenriched Dihydropyran Phosphonates via an Inverse-Electron-Demand Hetero-Diels–Alder Reaction

(2014) Christian F. Weise et al.   JOURNAL OF ORGANIC CHEMISTRY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH

(2014) R. Noël et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective synthesis of γ-tetrasubstituted nitrosulfonyl carboxylates and amides vial-tert-leucine-derived-squaramide catalyzed conjugate addition of nitrosulfones to acrylates and acrylamides

(2014) Kalisankar Bera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita–Baylis–Hillman reaction

(2014) Xiaorui Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Organocatalytic α-Sulfenylation of Azlactones

(2014) Baokun Qiao et al.   ORGANIC LETTERS

Asymmetric Synthesis of Tetrahydropyridines via an Organocatalytic One-Pot Multicomponent Michael/Aza-Henry/Cyclization Triple Domino Reaction

(2014) Marcus Blümel et al.   ORGANIC LETTERS

Streocontrolled Construction of Six Vicinal Stereogenic Centers on Spiropyrazolones via Organocascade Michael/Michael/1,2-Addition Reactions

(2014) Pankaj Chauhan et al.   ORGANIC LETTERS

Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines

(2014) Mei-Xin Zhao et al.   ORGANIC LETTERS

Squaramide Equilibrium Acidities in DMSO

(2014) Xiang Ni et al.   ORGANIC LETTERS

Straightforward Enantioselective Access to γ-Butyrolactones Bearing an All-Carbon β-Quaternary Stereocenter

(2014) Sara Meninno et al.   ORGANIC LETTERS

Asymmetric Synthesis of Highly Functionalized Tetrahydropyrans via a One-Pot Organocatalytic Michael/Henry/Ketalization Sequence

(2014) Robert Hahn et al.   ORGANIC LETTERS

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

(2014) Wangsheng Sun et al.   ORGANIC LETTERS

Lewis Base Catalysis of Three n–π* Mediated Reactions with N-Heterocyclic Carbenes (NHCs), Isothioureas, Bicyclic Tertiary Amines, and Electron-Rich Pyridyls

(2014) David Lupton et al.   SYNTHESIS-STUTTGART

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

(2014) Dieter Enders et al.   SYNTHESIS-STUTTGART

Organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction of 3-acetyl-oxindole with β,γ-unsaturated ketoesters catalyzed by bifunctional amino-squaramides

(2014) Jing Zhou et al.   TETRAHEDRON

BINOL–quinine–squaramides as efficient organocatalysts for the asymmetric Michael addition of 2-hydroxy-1,4-naphthoquinone to nitroalkenes

(2014) Enshan Zhou et al.   TETRAHEDRON-ASYMMETRY

Regioselective asymmetric stereoablative O-alkylation of α-nitrophosphonates via o-azaxylylene intermediates generated in situ from 3-bromooxindoles

(2014) Xiaohua Xie et al.   RSC Advances

Enantioselective synthesis of pyrazolone derivatives catalysed by a chiral squaramide catalyst

(2014) Jun-Hua Li et al.   RSC Advances

Organocatalytic asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to α-substituted β-nitroacrylates: facile construction of a chiral all-carbon quaternary center

(2014) Yuan Zhong et al.   RSC Advances

Asymmetric Organocatalytic Cascade Michael/Hemiketalization/Retro-Aldol Reaction of 2-[(E)-2-Nitrovinyl]phenols with 2,4-Dioxo-4-arylbutanoates: A Convenient Access to Chiral α-Keto Esters

(2013) Yunting Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Optically Active 2H-Thiopyrano[2,3-b]quinolines with Three Contiguous Stereocentersviaan Organocatalytic Asymmetric Tandem Michael-Henry Reaction

(2013) Lulu Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Enantioselective Cascade Aza-Michael/Michael Addition for the Synthesis of Highly Functionalized Tetrahydroquinolines and Tetrahydrochromanoquinolines

(2013) Wen Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Aza-Henry Reaction of Imines Bearing a Benzothiazole Moiety Catalyzed by aCinchona-Based Squaramide

(2013) Hai-Xiao He et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Functionalized Tetrahydronaphthalenesviaan Organocatalytic Nitroalkane-Michael/Henry Domino Reaction

(2013) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Michael Addition of 2-Hydroxy-1,4-naphthoquinone to β,γ-Unsaturated α-Keto Esters Catalyzed by Binaphthyl-Modified Squaramide

(2013) Ji Hyun Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Terpene-Derived Bifunctional Thioureas in Asymmetric Organocatalysis

(2013) Senthil Narayanaperumal et al.   ChemCatChem

Enantioselective synthesis of α-nitro-δ-ketosulfones via a quinine–squaramide catalyzed conjugate addition of α-nitrosulfones to enones

(2013) Kalisankar Bera et al.   CHEMICAL COMMUNICATIONS

Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes

(2013) Charles C. J. Loh et al.   CHEMICAL COMMUNICATIONS

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines

(2013) Wen Yang et al.   CHEMICAL COMMUNICATIONS

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

(2013) Jinlong Zhang et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of trans-dihydroarylfurans in a Friedel–Crafts/substitution domino reaction under squaramide catalysis

(2013) Carlos Jarava-Barrera et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

(2013) Li Tian et al.   CHEMICAL COMMUNICATIONS

Synergistic Lewis base and anion-binding catalysis for the enantioselective vinylogous addition of deconjugated butenolides to allenoates

(2013) Vikas Kumar et al.   CHEMICAL COMMUNICATIONS

Catalytic C–C Bond-Forming Multi-Component Cascade or Domino Reactions: Pushing the Boundaries of Complexity in Asymmetric Organocatalysis

(2013) Chandra M. R. Volla et al.   CHEMICAL REVIEWS

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

Origin of the Superior Performance of (Thio)Squaramides over (Thio)Ureas in Organocatalysis

(2013) Tongxiang Lu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Organocatalytic Methods for Asymmetric CC Bond Formation

(2013) Ulf Scheffler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bifunctional Primary Amine-Squaramide Catalyzed Enantioselective Intramolecular Michael Addition of Keto-enones: A Convenient Process to the Stereocontrolled Construction oftrans-Dihydrobenzofuran Skeletons

(2013) Yunting Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Squaramide-Catalysed Domino Mannich-Cyclization Reaction of Isatin Imines

(2013) Xi-Bo Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Organocatalytic Michael Addition/Cyclization Cascade Reaction of Ylideneoxindoles with Isothiocyanato Oxindoles: A Formal [3+2] Cycloaddition Approach to Optically Active Bispirooxindole Derivatives

(2013) Fen Tan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Michael Addition of 4-Hydroxycoumarins to β,γ-Unsaturated α-Oxophosphonates Catalysed by a Bifunctional Squaramide Bearing a Structurally Rigid 9,10-Ethylene-9,10-dihydroanthracene Skeleton

(2013) Xufang Chang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tether-Free Immobilized Bifunctional Squaramide Organocatalysts for Batch and Flow Reactions

(2013) György Kardos et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereodivergent Michael addition of diphenylphosphite to α-nitroalkenes in the presence of squaramide-derived tertiary amines: an enantioselective organocatalytic reaction in supercritical carbon dioxide

(2013) Ilya V. Kuchurov et al.   GREEN CHEMISTRY

Organocatalytic Cascade Sulfa-Michael/Aldol Reaction of β,β-Disubstituted Enones: Enantioselective Synthesis of Tetrahydrothiophenes with a Trifluoromethylated Quaternary Center

(2013) Yu Su et al.   JOURNAL OF ORGANIC CHEMISTRY

Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of α-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines

(2013) Mei-Xin Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Squaramide-Catalyzed Enantioselective Michael Addition of Masked Acyl Cyanides to Substituted Enones

(2013) Kin S. Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids

(2013) Kankan Zhang et al.   MOLECULES

Squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes

(2013) Jun-Hua Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Michael addition of 1,3-dicarbonyl compounds to a nitroalkene catalyzed by chiral squaramides – a key step in the synthesis of pregabalin

(2013) Rastislav Baran et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First example of quinine-squaramide catalyzed enantioselective addition of diphenyl phosphite to ketimines derived from isatins

(2013) Jimil George et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chiral squaramide-catalysed one-pot enantioselective sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides

(2013) Bo-Liang Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic enantioselective hydrophosphonylation of aldehydes

(2013) Juan V. Alegre-Requena et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rhodium/Chiral Urea Relay Catalysis Enables an Enantioselective Semipinacol Rearrangement/Michael Addition Cascade

(2013) Dian-Feng Chen et al.   ORGANIC LETTERS

Organocatalytic oxa/aza-Michael–Michael Cascade Strategy for the Construction of Spiro [Chroman/Tetrahydroquinoline-3,3′-oxindole] Scaffolds

(2013) Haibin Mao et al.   ORGANIC LETTERS

Squaramide–Tertiary Amine Catalyzed Asymmetric Cascade Sulfa-Michael/Michael Addition via Dynamic Kinetic Resolution: Access to Highly Functionalized Chromans with Three Contiguous Stereocenters

(2013) Wen Yang et al.   ORGANIC LETTERS

Continuous Flow, Highly Enantioselective Michael Additions Catalyzed by a PS-Supported Squaramide

(2013) Pinar Kasaplar et al.   ORGANIC LETTERS

Chiral Squaramide Catalyzed Asymmetric Conjugate Additions of 3-Substituted Oxindoles to Vinylphosphonates

(2013) Jia-Rong Chen et al.   SYNTHESIS-STUTTGART

Enantioselective Organocatalyzed Domino Synthesis of Six-Membered Carbocycles

(2013) Damien Bonne et al.   SYNTHESIS-STUTTGART

Guanidine Organocatalysis

(2013) Philipp Selig   SYNTHESIS-STUTTGART

Primary and secondary amine-(thio)ureas and squaramides and their applications in asymmetric organocatalysis

(2013) Michail Tsakos et al.   TETRAHEDRON

Enantioselective decarboxylative aldol addition of β-ketoacids to isatins catalyzed by binaphthyl-modified organocatalyst

(2013) Chang Won Suh et al.   TETRAHEDRON LETTERS

Chiral bifunctional squaramide catalyzed asymmetric tandem Michael-cyclization reaction: efficient synthesis of optically active 2-amino-4H-chromene-3-carbonitrile derivatives

(2013) Keling Hu et al.   TETRAHEDRON-ASYMMETRY

Highly enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes catalyzed by designer chiral BINOL–quinine–squaramide: efficient access to optically active nitro-alkanes and their isoxazole derivatives

(2013) Bin Liu et al.   TETRAHEDRON-ASYMMETRY

Cinchona based squaramide catalysed enantioselective Michael addition of α-nitrophosphonates to aryl acrylates: enantioselective synthesis of quaternary α-aminophosphonates

(2013) Truong Son Pham et al.   TETRAHEDRON-ASYMMETRY

Highly enantioselective direct vinylogous Michael addition of γ-substituted deconjugated butenolides to maleimides catalyzed by chiral squaramides

(2013) Yun-Long Guo et al.   RSC Advances

Squaramide-catalysed enantionselective Mannich reaction of imines bearing a heterocycle with malonates

(2013) Hai-Xiao He et al.   RSC Advances

Development of Cascade Reactions for the Concise Construction of Diverse Heterocyclic Architectures

(2012) Liang-Qiu Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent Developments in Asymmetric Organocatalytic Domino Reactions

(2012) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

Exploiting Acyl and Enol Azolium Intermediates via N-Hetero- cyclic Carbene-Catalyzed Reactions of α-Reducible Aldehydes

(2012) Harit U. Vora et al.   ADVANCED SYNTHESIS & CATALYSIS

A Polystyrene-Supported, Highly Recyclable Squaramide Organocatalyst for the Enantioselective Michael Addition of 1,3-Dicarbonyl Compounds to β-Nitrostyrenes

(2012) Pinar Kasaplar et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Organocatalytic Michael Addition of Cyclobutanones to Nitroalkenes

(2012) Damien Mailhol et al.   ADVANCED SYNTHESIS & CATALYSIS

Dienamine-Mediated Inverse-Electron-Demand Hetero-Diels-Alder Reaction by Using an Enantioselective H-Bond-Directing Strategy

(2012) Łukasz Albrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective H-Bond-Directing Approach for Trienamine-mediated Reactions in Asymmetric Synthesis

(2012) Łukasz Albrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Activation of Polycyclic Aromatic Compounds for Asymmetric Diels-Alder Reactions

(2012) Hao Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cinchona-based Primary Amine Catalysis in the Asymmetric Functionalization of Carbonyl Compounds

(2012) Paolo Melchiorre   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones

(2012) Sergei Žari et al.   Beilstein Journal of Organic Chemistry

Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach

(2012) Pankaj Chauhan et al.   Beilstein Journal of Organic Chemistry

An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

(2012) Shu-Wen Duan et al.   CHEMICAL COMMUNICATIONS

Catalytic, enantio- and diastereoselective synthesis of γ-butyrolactones incorporating quaternary stereocentres

(2012) Francesco Manoni et al.   CHEMICAL COMMUNICATIONS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic, Asymmetric Synthesis of 3-SulfenylatedN-Boc-Protected Oxindoles

(2012) Chuan Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Formal [3+2] Cycloaddition Reaction of α-Aryl Isocyanoesters withN-Aryl Maleimides by Bifunctional Cinchona Alkaloids-Based Squaramide/AgSbF6Cooperative Catalysis

(2012) Mei-Xin Zhao et al.   Chemistry-An Asian Journal

Enantioselective Asymmetric Michael Addition of Cyclic Diketones to β,γ-Unsaturated α-Keto Esters

(2012) Yi-Feng Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill

(2012) Yi-Feng Wang et al.   GREEN CHEMISTRY

Bifuctional Amino-Squaramides Catalyzed Asymmetric Spiroannulation Cascades with Aliphatic β,γ-Unsaturated α-Keto Esters: Controlling an Aldehyde Enolate

(2012) Xiaoqin Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Organocatalytic Formal [2 + 2]-Cycloadditions via Bifunctional H-Bond Directing Dienamine Catalysis

(2012) Łukasz Albrecht et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Squaramide-catalysed enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes

(2012) Wen Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Iodolactonization Utilizing Chiral Squaramides

(2012) Jørn E. Tungen et al.   ORGANIC LETTERS

Hydrogen-Bond-Mediated Cascade Reaction Involving Chalcones: Facile Synthesis of Enantioenriched Trisubstituted Tetrahydrothiophenes

(2012) Jun-Bing Ling et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Synthesis of 3-Chlorooxindoles Bearing Adjacent Quaternary–Tertiary Centers

(2012) Artur Noole et al.   ORGANIC LETTERS

A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides

(2012) Claudio Cornaggia et al.   ORGANIC LETTERS

Toward a Total Synthesis of Divergolide A; Synthesis of the Amido Hydro- quinone Core and the C10–C15 Fragment

(2012) Wei-Min Dai et al.   SYNLETT

NHCs in Asymmetric Organocatalysis: Recent Advances in Azolium Enolate Generation and Reactivity

(2012) Andrew Smith et al.   SYNTHESIS-STUTTGART

Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel–Crafts reaction of indoles with alkyl trifluoropyruvate

(2012) Xin Han et al.   TETRAHEDRON-ASYMMETRY

Enantioselective synthesis of 2-amino-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitriles using squaramide as the catalyst

(2012) Yu Gao et al.   TETRAHEDRON-ASYMMETRY

Squaramide-catalyzed diastereo- and enantioselective Michael addition of 3-substituted oxindoles to nitroalkenes

(2012) Wen Yang et al.   TETRAHEDRON-ASYMMETRY

Chiral squaramide as multiple H-bond donor organocatalysts for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins

(2012) Ze Dong et al.   TETRAHEDRON-ASYMMETRY

An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3-symmetric cinchonine-squaramide catalysts

(2012) Xin Han et al.   RSC Advances

Chiral phosphine-squaramide-catalyzed Morita–Baylis–Hillman reaction: enantioselective synthesis of 3-hydroxy-2-oxindoles

(2012) Jing-Ying Qian et al.   RSC Advances

The Diarylprolinol Silyl Ether System: A General Organocatalyst

(2011) Kim L. Jensen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Organocatalytic Enantioselective Michael-Addition of Malonic Acid Half-Thioesters to β-Nitroolefins: From Mimicry of Polyketide Synthases to Scalable Synthesis of γ-Amino Acids

(2011) Han Yong Bae et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins

(2011) Noriyuki Hara et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Squaramide-Catalyzed Highly Enantioselective Michael Addition of 2-Hydroxy-1,4-naphthoquinones to Nitroalkenes

(2011) Wen Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

C3-Symmetrical Cinchonine-Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition

(2011) Chang Min et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple Recipe for Sophisticated Cocktails: Organocatalytic One-Pot Reactions-Concept, Nomenclature, and Future Perspectives

(2011) Łukasz Albrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Association-Free and Recyclable, Dimeric Cinchona Alkaloid Organocatalysts for Methanolytic Desymmetrization of meso-Glutaric Anhydrides

(2011) Eun-Hye Nam et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Enantioselective Conjugate Addition of Anthrone to Nitroalkenes Catalyzed by Binaphthyl-Modified Organocatalyst

(2011) Hyun-Joo Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Hydrogen bonding mediated enantioselective organocatalysis in brine: significant rate acceleration and enhanced stereoselectivity in enantioselective Michael addition reactions of 1,3-dicarbonyls to β-nitroolefins

(2011) Han Yong Bae et al.   CHEMICAL COMMUNICATIONS

Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes

(2011) Wen Yang et al.   CHEMICAL COMMUNICATIONS

Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

(2011) Albert Moyano et al.   CHEMICAL REVIEWS

Squaramides: physical properties, synthesis and applications

(2011) R. Ian Storer et al.   CHEMICAL SOCIETY REVIEWS

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

(2011) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Phosphoric Acid Catalysts

(2011) Masahiro Terada   CURRENT ORGANIC CHEMISTRY

Organocatalytic Direct Asymmetric Vinylogous Michael Reaction of an α,β-Unsaturated γ-Butyrolactam with Enones

(2011) Yong Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones

(2011) Joong-Suk Oh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of (+)-L-733,060, (+)-CP-99,994 and (2S,3R)-3-hydroxypipecolic acid: Application of an organocatalytic direct vinylogous aldol reaction

(2011) Sunil V. Pansare et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

(2011) Wen Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Synthesis of α-Alkyl α-Selenocarbonyl Compounds Catalyzed by Bifunctional Organocatalysts

(2011) Vanesa Marcos et al.   ORGANIC LETTERS

Recent applications of Cinchona alkaloids and their derivatives as catalysts in metal-free asymmetric synthesis

(2011) Elizabeth M.O. Yeboah et al.   TETRAHEDRON

A novel C3-symmetric prolinol-squaramide catalyst for the asymmetric reduction of ketones by borane

(2011) Xiang-Fei Wu et al.   TETRAHEDRON-ASYMMETRY

Asymmetric organocatalytic reactions by bifunctional amine-thioureas

(2011) Woon-Yew Siau et al.   Catalysis Science & Technology

Aromatic hydroxyl group—a hydrogen bonding activator in bifunctional asymmetric organocatalysis

(2011) Pankaj Chauhan et al.   RSC Advances

A Bifunctional Cinchona Alkaloid-Squaramide Catalyst for the Highly Enantioselective Conjugate Addition of Thiols to trans-Chalcones

(2010) Le Dai et al.   ADVANCED SYNTHESIS & CATALYSIS

Squaramide-catalyzed enantioselective Friedel–Crafts reaction of indoles with imines

(2010) Yong Qian et al.   CHEMICAL COMMUNICATIONS

Mechanisms in aminocatalysis

(2010) Martin Nielsen et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric direct vinylogous aldol reactions of γ-crotonolactone with aromatic aldehydes

(2010) Sunil V. Pansare et al.   CHEMICAL COMMUNICATIONS

Chiral phosphine-squaramides as enantioselective catalysts for the intramolecular Morita–Baylis–Hillman reaction

(2010) Hong-Liang Song et al.   CHEMICAL COMMUNICATIONS

Chiral Squaramides as Highly Enantioselective Catalysts for Michael Addition Reactions of 4-Hydroxycoumarins and 4-Hydroxypyrone to β,γ-Unsaturated α-Keto Esters

(2010) Dan-Qian Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Organocatalytic Michael Addition of 2-Hydroxy- 1,4-naphthoquinone to β,γ-Unsaturated α-Oxo Esters

(2010) Yi-Feng Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Acyl Phosphonates: Good Hydrogen Bond Acceptors and Ester/Amide Equivalents in Asymmetric Organocatalysis

(2010) Hao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

DOSY NMR for monitoring self aggregation of bifunctional organocatalysts: increasing enantioselectivity with decreasing catalyst concentration

(2010) Hyeong Bin Jang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Michael Addition of Nitroalkanes to Chalcones Using Chiral Squaramides as Hydrogen Bonding Organocatalysts

(2010) Wen Yang et al.   ORGANIC LETTERS

Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts

(2010) Hideyuki Konishi et al.   ORGANIC LETTERS

Chiral Phosphoric Acids as Versatile Catalysts for Enantioselective Transformations

(2010) Masahiro Terada   SYNTHESIS-STUTTGART

Cinchona Alkaloids in Asymmetric Organocatalysis

(2010) Tommaso Marcelli et al.   SYNTHESIS-STUTTGART

Squaramide-Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroalkenes

(2009) Ye Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bicyclic-guanidines, -guanidinates and -guanidinium salts: wide ranging applications from a simple family of molecules

(2009) Martyn P. Coles   CHEMICAL COMMUNICATIONS

(Thio)urea organocatalysis—What can be learnt from anion recognition?

(2009) Zhiguo Zhang et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Aminocatalysis-Gold Rush in Organic Chemistry

(2008) Paolo Melchiorre et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Guanidine Catalyzed Enantioselective Reactions

(2008) Dasheng Leow et al.   Chemistry-An Asian Journal

Chiral Squaramide Derivatives are Excellent Hydrogen Bond Donor Catalysts

(2008) Jeremiah P. Malerich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE

Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines

(2008) Xinhong Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY