Article
Chemistry, Organic
Rimpa De, Avantika Hasija, Deepak Chopra, Mrinal K. Bera
Summary: A practical and efficient method for the construction of poly substituted oxazoles was developed using a catalytic amount of potassium iodide and TBHP as the green oxidant via amidation followed by intramolecular oxidative cyclization of enaminone derivatives under mild reaction conditions. The attractive feature of this method is the simultaneous oxidation of benzylic CeH bond and dehydrogenation of enaminone in one pot under base free conditions.
Review
Chemistry, Multidisciplinary
Conghui Tang, Xu Qiu, Zengrui Cheng, Ning Jiao
Summary: Molecular oxygen, as a green and non-toxic oxidant, offers various advantages in organic transformations for the synthesis of oxygen-containing compounds. Recent advances in radical processes using molecular oxygen as an oxidant have been discussed, along with reaction scopes, limitations, and mechanisms, providing insights for future developments in this field.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Organic
Anshul Jain, Akanksha Kumari, Khyati Shukla, Selvakumar Sermadurai, Nirmal K. Rana
Summary: An efficient and solvent-controlled diastereodivergent thia-Michael/aldol cascade synthesis of tetrahydrothiophenes (THTs) has been developed. The cascade reaction is catalyzed by polystyrene-supported amine to afford trisubstituted tetrahydrothiophene derivatives in excellent yields and diastereoselectivities. A broad range of substrate tolerance is examined under two different solvents to access a library of diastereomeric THTs. Moreover, the polymer-supported amines can be recovered and reused for the cascade reaction.
Article
Chemistry, Physical
Changjiao Shang, Yajie Zhang, Chaofan Sun, Lingling Wang
Summary: In this study, the substituent and solvent effects on the antioxidant activity of 2'-hydroxychalcone were investigated in different phases. The results provide guidance for synthesizing high-efficiency antioxidants and explore potential application fields for 2'Cha.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Organic
Mengzhu Guo, Fengying Dong, Xiangcong Yin, Lubin Xu, Liang Wang, Shuai-Shuai Li
Summary: In this study, medicinally significant 3-monosubstituted tetrahydroquinolines and 1,2-dihydroquinolines were controllably constructed via a redox-neutral vinylogous cascade condensation/[1,5]-hydride transfer/cyclization process in ethanol, showcasing novel features such as green solvent and metal-free conditions. Additionally, the electrophilicity and nucleophilicity of alpha,alpha-dicyanoalkenes were effectively utilized as hydride acceptors and gamma-exclusive nucleophiles.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Xiaoning Li, Zunsheng Chen, Weiming Chen, Xin Xie, Hui Zhou, Yingmei Liao, Fuchao Yu, Jiuzhong Huang
Summary: This paper describes a B2pin2-mediated radical cascade cyclization/aromatization reaction of enaminone with pyridine, providing a practical way for constructing valuable functionalized indolizines under metal-, external oxidant-, and base-free conditions. The reaction is compatible with various functional groups and is triggered by the in situ formation of a pyridine-boryl radical.
Article
Biochemistry & Molecular Biology
Honey Jain, Konstantina Karathanou, Ana-Nicoleta Bondar
Summary: Phosphatidylserine lipids, anionic molecules found in eukaryotic plasma membranes, play essential roles in cellular physiology. Understanding the altered distribution of phosphatidylserine, particularly in apoptotic cancer cells, has important implications for biomarker development. This study utilizes a graph algorithm to study the dynamics of water-mediated lipid clusters at the interface of a model bilayer, providing insights into the behavior of phosphatidylserine in the presence of cholesterol.
Article
Chemistry, Applied
Dingwei Zhao, Mi Feng, Ling Zhang, Bin He, Xinyan Chen, Jian Sun
Summary: A novel method was developed to prepare a semi-interpenetrating polymer network (semi-IPN) hydrogel with improved properties, based on sodium alginate (SA) and polyacrylamide (PAM). The formation mechanism of a layered structure through hydrogen bonds (HBs) and the key role of HBs in enhancing self-healing of the hydrogel were systematically characterized. The semi-IPN structure resulted in a high tensile strength of 266 kPa and broadened the functionality and variety of hydrogels.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Muniganti Naveen Kumar, Vavilapalli Suresh, Attunuri Nagireddy, Jagadeesh Babu Nanubolu, Maddi Sridhar Reddy
Summary: Annulations of unsaturated systems through C-H activation are a powerful tool for producing multicyclic scaffolds. Employing a dual coordination strategy with coordinating centers in both annulation partners can lead to remarkable selectivities. In this study, we report a Pd-catalyzed regioselective rollover cascade dual C-H annulation for constructing phenanthrene scaffolds. Mechanism studies, including control experiments, KIE, and deuteration experiments, were conducted, and downstream transformations and scaled-up reactions were performed to evaluate the robustness of the transformation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Sudhir Kumar Hota, Satya Prakash Panda, Sanju Das, Sanat Kumar Mahapatra, Lisa Roy, Suman De Sarkar, Sandip Murarka
Summary: We proposed a novel disconnection approach to synthesize fused tetrahydroquinolines through a visible light-mediated radical (4 + 2) annulation reaction between alkyl N-(acyloxy)-phthalimides and N-substituted maleimides using DIPEA as an additive. The reaction involves a photoactivated electron donor-acceptor complex between alkyl NHPI esters and DIPEA, and regioselective tetrahydroquinolines were obtained. This metal-and catalyst-free methodology exhibits a wide scope, good functional group tolerance, and detailed mechanistic investigations were performed.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Farnaz Jafarpour, Banafshe Rahimi
Summary: A novel controlled DTBP-mediated oxidative C-S bond cleavage/annulation cascade is developed, allowing benzyl thioethers to form carbonyl intermediates and participate in annulation reactions with alkynes to produce privileged indenone skeletons.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Paper & Wood
Yachong Zhu, Chaojun Wu, Dongmei Yu, Qijun Ding, Ronggang Li
Summary: In this study, CNFs were prepared from pre-hydrolyzed eucalyptus raw materials, and the impact of prehydrolysis conditions on the micro-structure of CNFs was investigated. Higher prehydrolysis temperature led to increased crystallinity of CNFs, while prolonged prehydrolysis treatment resulted in the formation of numerous nanopores on the surface of CNFs by breaking hydrogen bonds.
Article
Chemistry, Physical
Yi-Fan Liao, Mu-Han Zhou, Yang Zhang, Ying-Ying Peng, Jing-Xin Jian, Feng Lu, Qing-Xiao Tong
Summary: Three pH-responsive fluorosurfactants were synthesized in this study, with F-9-N-2-mor efficiently reducing water surface tension at a low critical micelle concentration and showing reproducible foaming behavior at specific pH values. Moreover, the morpholine fluorosurfactants defoam in low pH environments, aiding in recycling efforts.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Man Tang, Wenyan Zhu, Huaxing Sun, Jing Wang, Su Jing, Minyan Wang, Zhuangzhi Shi, Jiefeng Hu
Summary: Efficient synthesis methods for organosilanes are important in the fields of synthetic chemistry and materials science. In this study, an alkoxide base-promoted deborylative silylation reaction was developed, providing straightforward access to valuable organosilanes. This method demonstrates operational simplicity, broad substrate scope, excellent functional group compatibility, and convenient scalability, making it an effective and complementary platform for generating diversified benzyl silanes and silylboronates. Detailed experimental results and mechanistic studies revealed unique features of the C-Si bond formation.
Article
Chemistry, Organic
Li-Sheng Wang, You Zhou, Shuang-Gui Lei, Xiao-Xiao Yu, Chun Huang, Yan-Dong Wu, An-Xin Wu
Summary: A novel multicomponent cascade reaction has been reported for the synthesis of imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C-N bonds and one C-S/C-Se bond. The reaction achieves simultaneous C(sp3)-H amination and sulfenylation/selenation, avoiding complicated substrate preparation. It has simple operating conditions and good substrate compatibility.
Article
Chemistry, Analytical
Cheng Ma, Jingyao Qu, Jeffrey Meisner, Xinyuan Zhao, Xu Li, Zhigang Wu, Hailiang Zhu, Zaikuan Yu, Lei Li, Yuxi Guo, Jing Song, Peng George Wang
ANALYTICAL CHEMISTRY
(2015)
Article
Biochemical Research Methods
Zhigang Wu, Kuan Jiang, Hailiang Zhu, Cheng Ma, Zaikuan Yu, Lei Li, Wanyi Guan, Yunpeng Liu, He Zhu, Yanyi Chen, Shanshan Li, Jing Li, Jiansong Cheng, Lianwen Zhang, Peng George Wang
BIOCONJUGATE CHEMISTRY
(2016)
Article
Chemistry, Organic
Jun Zhou, Yunpeng Liu, Hailiang Zhu, He Zhu, Peng George Wang
HETEROCYCLIC COMMUNICATIONS
(2017)
Review
Chemistry, Multidisciplinary
Liuqing Wen, Garrett Edmunds, Christopher Gibbons, Jiabin Zhang, Madhusudhan Reddy Gadi, Hailiang Zhu, Junqiang Fang, Xianwei Liu, Yun Kong, Peng George Wang
Article
Chemistry, Applied
Yong-Fei Chen, Hai-Fei Wang, Ya Wang, Yong-Chun Luo, Hai-Liang Zhu, Peng-Fei Xu
ADVANCED SYNTHESIS & CATALYSIS
(2010)
Article
Chemistry, Organic
Hai-Liang Zhu, Jun-Bing Ling, Peng-Fei Xu
JOURNAL OF ORGANIC CHEMISTRY
(2012)
Article
Chemistry, Medicinal
Hailiang Zhu, Zhigang Wu, Madhusudhan Reddy Gadi, Shuaishuai Wang, Yuxi Guo, Garrett Edmunds, Wanyi Guan, Junqiang Fang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Chemistry, Multidisciplinary
Yangyang Xu, Zhigang Wu, Peiru Zhang, He Zhu, Hailiang Zhu, Qitao Song, Li Wang, Faxing Wang, Peng George Wang, Jiansong Cheng
CHEMICAL COMMUNICATIONS
(2017)
