High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection

(2011) Maritza Jaramillo et al.   Cell Host & Microbe

Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation

(2011) Pascale Pescher et al.   CELLULAR MICROBIOLOGY

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

(2011) Geraldine De Muylder et al.   PLoS Neglected Tropical Diseases

New antileishmanial candidates and lead compounds

(2010) Julian V Richard et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Analysis of Stage-Specific Expression of Basic Proteins inLeishmania infantum

(2010) Marie-Christine Brotherton et al.   JOURNAL OF PROTEOME RESEARCH

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas

(2010) Jean-Claude Dujardin et al.   TRENDS IN PARASITOLOGY

Antimony Toxicity

(2010) Shyam Sundar et al.   International Journal of Environmental Research and Public Health

Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

(2010) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7

(2010) Rebecca Phillips et al.   PLoS Pathogens

In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences

(2009) M. Vermeersch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes

(2009) Jose Osorio y Fortea et al.   BMC GENOMICS

Sorting of Leishmania-bearing dendritic cells reveals subtle parasite-induced modulation of host-cell gene expression

(2009) Hervé Lecoeur et al.   MICROBES AND INFECTION

Statistical methods for analysis of high-throughput RNA interference screens

(2009) Amanda Birmingham et al.   NATURE METHODS

Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen

(2009) Elizabeth R. Sharlow et al.   PLoS Neglected Tropical Diseases

A new Heck reaction modification using ketone Mannich bases as enone precursors: Parallel synthesis of anti-leishmanial chalcones

(2008) Christina Reichwald et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of differentiating agents (all-trans retinoic acid and phorbol 12-myristate 13-acetate) on drug sensitivity of HL60 and NB4 cells in vitro.

(2008) Ewa Jasek et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

2-(3-Aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: A New Antileishmanial Chemotype

(2008) Christina Reichwald et al.   JOURNAL OF MEDICINAL CHEMISTRY

Post-translational modification of cellular proteins duringLeishmania donovani differentiation

(2008) Doron Rosenzweig et al.   PROTEOMICS

Drug regimens for visceral leishmaniasis in Mediterranean countries

(2008) Luigi Gradoni et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Retooling Leishmania metabolism: from sand fly gut to human macrophage

(2007) Doron Rosenzweig et al.   FASEB JOURNAL