Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

(2011) P. Timpson et al.   CANCER RESEARCH

Intravital microscopy: new insights into metastasis of tumors

(2011) E. Beerling et al.   JOURNAL OF CELL SCIENCE

The beautiful cell: high-content screening in drug discovery

(2010) Marc Bickle   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

(2010) M. Canel et al.   CANCER RESEARCH

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

(2010) Alicia M. Cole et al.   EMBO Molecular Medicine

Intravital microscopy: a novel tool to study cell biology in living animals

(2010) Roberto Weigert et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Two-color Photoactivatable Probe for Selective Tracking of Proteins and Cells

(2010) Arkadiusz Welman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

(2010) Brendan Doyle et al.   JOURNAL OF PATHOLOGY

High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

(2010) P. D. Caie et al.   MOLECULAR CANCER THERAPEUTICS

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

(2010) Xiaobo Wang et al.   NATURE CELL BIOLOGY

In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays

(2010) Hernán E Grecco et al.   NATURE METHODS

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation

(2010) I Ahmad et al.   ONCOGENE

Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane

(2010) Marta Canel et al.   Cell Adhesion & Migration

Real-time Study of E-Cadherin and Membrane Dynamics in Living Animals: Implications for Disease Modeling and Drug Development

(2009) A. Serrels et al.   CANCER RESEARCH

Applications of High Content Screening in Life Science Research

(2009) Joseph Zock   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

NIR dyes for bioimaging applications

(2009) Jorge O Escobedo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A fluorescence lifetime imaging scanning confocal endomicroscope

(2009) Gordon T. Kennedy et al.   Journal of Biophotonics

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Quantum Dots for In Vivo Small-Animal Imaging

(2009) L. A. Bentolila et al.   JOURNAL OF NUCLEAR MEDICINE

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

(2009) Silvia Giampieri et al.   NATURE CELL BIOLOGY

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

(2009) Jean Y Perentes et al.   NATURE METHODS

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome

(2009) X. Shu et al.   SCIENCE

The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients

(2009) Muireann T. Kelleher et al.   Targeted Oncology

Near-infrared fluorescent probes for imaging vascular pathophysiology

(2008) Jan Klohs et al.   BASIC RESEARCH IN CARDIOLOGY

Multiplexed FRET to Image Multiple Signaling Events in Live Cells

(2008) David M. Grant et al.   BIOPHYSICAL JOURNAL

Fluorescence lifetime imaging distinguishes basal cell carcinoma from surrounding uninvolved skin

(2008) N.P. Galletly et al.   BRITISH JOURNAL OF DERMATOLOGY

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover

(2008) Neil O. Carragher   CLINICAL & EXPERIMENTAL METASTASIS

High speed unsupervised fluorescence lifetime imaging confocal multiwell plate reader for high content analysis

(2008) Clifford B. Talbot et al.   Journal of Biophotonics

Intravital imaging of metastatic behavior through a mammary imaging window

(2008) Dmitriy Kedrin et al.   NATURE METHODS

Microscopic imaging techniques for drug discovery

(2007) Andrew Bullen   NATURE REVIEWS DRUG DISCOVERY