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Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology

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Drugging cancer genomes

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canSAR: updated cancer research and drug discovery knowledgebase

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PDBe: Protein Data Bank in Europe

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Cancer Genome Landscapes

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Unpicking the Combination Lock for Mutant BRAF and RAS Melanomas

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Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction

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Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition

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The Analysis of the Druggable Families Based on Topological Features in the Protein-Protein Interaction Network

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The Core Diseasome

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Combinatorial drug therapy for cancer in the post-genomic era

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Quantifying the chemical beauty of drugs

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Protein interaction data curation: the International Molecular Exchange (IMEx) consortium

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Objective assessment of cancer genes for drug discovery

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Targeting tumor cell metabolism with statins

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Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer

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Genotype-Selective Combination Therapies for Melanoma Identified by High-Throughput Drug Screening

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Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

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canSAR: an integrated cancer public translational research and drug discovery resource

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ChEMBL: a large-scale bioactivity database for drug discovery

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Protein interaction network topology uncovers melanogenesis regulatory network components within functional genomics datasets

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The function of communities in protein interaction networks at multiple scales

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The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

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Properties and identification of human protein drug targets

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The pairwise disconnectivity index as a new metric for the topological analysis of regulatory networks

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Finding local communities in protein networks

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Discovering cancer genes by integrating network and functional properties

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mTOR signaling at a glance

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Identifying drug-target proteins based on network features

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Structure of Protein Interaction Networks and Their Implications on Drug Design

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Predicting cancer involvement of genes from heterogeneous data

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GraphCrunch: A tool for large network analyses

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Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

An empirical framework for binary interactome mapping

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Genomic-scale prioritization of drug targets: the TDR Targets database

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Drug Target Identification Using Side-Effect Similarity

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