Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

In vitroModel for Assessing Arrhythmogenic Properties of Drugs Based on High-resolution Impedance Measurements

(2013) Filomain Nguemo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Cellular Impedance Assays for Predictive Preclinical Drug Screening of Kinase Inhibitor Cardiovascular Toxicity

(2013) Sarah D. Lamore et al.   TOXICOLOGICAL SCIENCES

Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model

(2013) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

(2013) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays

(2013) Kate Harris et al.   TOXICOLOGICAL SCIENCES

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity

(2013) Oksana Sirenko et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

(2013) Clay W Scott et al.   TOXICOLOGY LETTERS

Evaluation of Cellular Impedance Measures of Cardiomyocyte Cultures for Drug Screening Applications

(2012) Matthew F. Peters et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture

(2012) Adam W. Feinberg et al.   BIOMATERIALS

Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility

(2012) Adriana Blazeski et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Validation of an in vitro contractility assay using canine ventricular myocytes

(2012) A.R. Harmer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry

(2012) Fabio Cerignoli et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-Derived Cardiomyocytes

(2011) Malin K.B. Jonsson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

(2011) Yama A Abassi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2011) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

(2011) J.D. Cohen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biohybrid thin films for measuring contractility in engineered cardiovascular muscle

(2010) Patrick W. Alford et al.   BIOMATERIALS

Label-free whole-cell assays: expanding the scope of GPCR screening

(2010) Clay W Scott et al.   DRUG DISCOVERY TODAY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer

(2010) Howard R. Mellor et al.   TOXICOLOGICAL SCIENCES

Model of Excitation-Contraction Coupling of Rat Neonatal Ventricular Myocytes

(2009) Topi Korhonen et al.   BIOPHYSICAL JOURNAL

Enhanced Selectivity Screening of GPCR Ligands Using a Label-Free Cell Based Assay Technology

(2009) Ryan McGuinness et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells

(2009) Igal Germanguz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Absence of Transverse Tubules Contributes to Non-Uniform Ca2+ Wavefronts in Mouse and Human Embryonic Stem Cell–Derived Cardiomyocytes

(2009) Deborah K. Lieu et al.   STEM CELLS AND DEVELOPMENT

Balancing Drug Risk and Benefit: Toward Refining the Process of FDA Decisions Affecting Patient Care

(2008) Lawrence R. Schiller et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY