Lipid Peroxidation and Antioxidant Protection

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

(2023) Riccardo Matera et al.   MOLECULES

Identification of essential sites of lipid peroxidation in ferroptosis

(2023) A. Nikolai von Krusenstiern et al.   Nature Chemical Biology

Relationship between 4-Hydroxynonenal (4-HNE) as Systemic Biomarker of Lipid Peroxidation and Metabolomic Profiling of Patients with Prostate Cancer

(2023) Matea Nikolac Perkovic et al.   Biomolecules

Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments

(2023) Mohammad Yasin Zamanian et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Plasmalogens: Free Radical Reactivity and Identification of Trans Isomers Relevant to Biological Membranes

(2023) Carla Ferreri et al.   Biomolecules

Geometrical isomerization of arachidonic acid during lipid peroxidation interferes with ferroptosis

(2023) Yusuke Hirata et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Regulation of Ferroptosis in Cancer Therapy

(2023) Xiaoxia Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Sulphur and Heavier Chalcogens on the Antioxidant Power and Bioactivity of Natural Phenolic Compounds

(2022) Maria Laura Alfieri et al.   Biomolecules

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

(2022) Eikan Mishima et al.   NATURE

Unravelling mechanisms of protein and lipid oxidation in mayonnaise at multiple length scales

(2022) Suyeon Yang et al.   FOOD CHEMISTRY

Lipid peroxide-derived short-chain aldehydes promote programmed cell death in wheat roots under aluminum stress

(2022) Xin Liang et al.   JOURNAL OF HAZARDOUS MATERIALS

Anti-tyrosinase and antioxidant activity of meroterpene bakuchiol from Psoralea corylifolia (L.)

(2022) Alice Cariola et al.   FOOD CHEMISTRY

Hydrogen Atom Transfer from HOO• to ortho‐Quinones Explains the Antioxidant Activity of Polydopamine

(2021) Yafang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Chain-Breaking Antioxidants and Their Synthetic Analogs as Modulators of Oxidative Stress

(2021) Vessela D. Kancheva et al.   Antioxidants

Absolute Antioxidant Activity of Five Phenol-Rich Essential Oils

(2021) Yafang Guo et al.   MOLECULES

Reductive Stress of Sulfur-Containing Amino Acids within Proteins and Implication of Tandem Protein–Lipid Damage

(2021) Chryssostomos Chatgilialoglu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insight into the Double-Edged Role of Ferroptosis in Disease

(2021) Lei Zhang et al.   Biomolecules

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

(2020) Piotr Wójcik et al.   Biomolecules

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals

(2020) Jia-Fei Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

(2020) Plamena R. Angelova et al.   MEDICINAL RESEARCH REVIEWS

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Urinary 8-isoprostane as a biomarker for oxidative stress. A systematic review and meta-analysis

(2020) M. Graille et al.   TOXICOLOGY LETTERS

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

(2020) Ángel Cores et al.   Biomolecules

Synergic Antioxidant Activity of γ-Terpinene with Phenols and Polyphenols Enabled by Hydroperoxyl Radicals

(2020) Yafang Guo et al.   FOOD CHEMISTRY

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

Role of Glutathione in Cancer: From Mechanisms to Therapies

(2020) Luke Kennedy et al.   Biomolecules

Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease

(2020) Morgan K. Foret et al.   CHEMICAL REVIEWS

Development and Application of a Peroxyl Radical Clock Approach for Measuring Both Hydrogen-Atom Transfer and Peroxyl Radical Addition Rate Constants

(2020) Quynh Do et al.   JOURNAL OF ORGANIC CHEMISTRY

H-Atom Abstraction vs. Addition: Accounting for the Diverse Product Distribution in the Autoxidation of Cholesterol & its Esters

(2019) Zosia A. M. Zielinski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological effect of protein modifications by lipid peroxidation products

(2019) Agnieszka Gęgotek et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Free radicals in Alzheimer's disease: Lipid peroxidation biomarkers

(2019) Carmen Peña-Bautista et al.   CLINICA CHIMICA ACTA

Calibration of Squalene, p-Cymene and Sunflower Oil as Standard Oxidizable Substrates for Quantitative Antioxidant Testing

(2019) Andrea Baschieri et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Emissive Enhancement of the Singlet Oxygen Chemiluminescence Probe after Binding to Bovine Serum Albumin

(2019) Miranda-Apodaca et al.   MOLECULES

Lipid peroxidation in neurodegeneration

(2019) Carmen Peña-Bautista et al.   CLINICA CHIMICA ACTA

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Structural Lesions of Proteins Connected to Lipid Membrane Damages Caused by Radical Stress: Assessment by Biomimetic Systems and Raman Spectroscopy

(2019) Torreggiani et al.   Biomolecules

Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: Results from a large, population-based cohort study with 14 years of follow-up

(2018) Xīn Gào et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methods To Measure the Antioxidant Activity of Phytochemicals and Plant Extracts

(2018) Riccardo Amorati et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Extremely fast hydrogen atom transfer between nitroxides and HOO• radicals and implication in catalytic co-antioxidant systems

(2018) Andrea Baschieri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of hydrocarbon autoxidation by nitroxide-catalyzed cross-dismutation of hydroperoxyl and alkylperoxyl radicals

(2018) Kareem A. Harrison et al.   Chemical Science

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Redox Signaling by Reactive Electrophiles and Oxidants

(2018) Saba Parvez et al.   CHEMICAL REVIEWS

Low doses of methylmercury exposure during adulthood in rats display oxidative stress, neurodegeneration in the motor cortex and lead to impairment of motor skills

(2018) Luana Nazaré da Silva Santana et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Explaining the antioxidant activity of some common non-phenolic components of essential oils

(2017) Andrea Baschieri et al.   FOOD CHEMISTRY

Enzymatic and free radical formation of cis - and trans - epoxyeicosatrienoic acids in vitro and in vivo

(2017) Theresa Aliwarga et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid Peroxidation: Kinetics, Mechanisms, and Products

(2017) Zosia A. M. Zielinski et al.   JOURNAL OF ORGANIC CHEMISTRY

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Peroxyl Radical Reactions in Water Solution: A Gym for Proton-Coupled Electron-Transfer Theories

(2016) Riccardo Amorati et al.   CHEMISTRY-A EUROPEAN JOURNAL

Comparison of Thiyl, Alkoxyl, and Alkyl Radical Addition to Double Bonds: The Unusual Contrasting Behavior of Sulfur and Oxygen Radical Chemistry

(2016) Isa Degirmenci et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Acid Is Key to the Radical-Trapping Antioxidant Activity of Nitroxides

(2016) Evan A. Haidasz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maximizing the Reactivity of Phenolic and Aminic Radical-Trapping Antioxidants: Just Add Nitrogen!

(2015) Luca Valgimigli et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rapid liquid chromatography–tandem mass spectrometry analysis of 4-hydroxynonenal for the assessment of oxidative degradation and safety of vegetable oils

(2015) Simone Gabbanini et al.   ANALYTICA CHIMICA ACTA

Quantitative Chemoproteomics for Site-Specific Analysis of Protein Alkylation by 4-Hydroxy-2-Nonenal in Cells

(2015) Jing Yang et al.   ANALYTICAL CHEMISTRY

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Acylated anthocyanins from sprouts of Raphanus sativus cv. Sango: Isolation, structure elucidation and antioxidant activity

(2015) Riccardo Matera et al.   FOOD CHEMISTRY

Novel approaches to identify protein adducts produced by lipid peroxidation

(2015) S. G. Codreanu et al.   FREE RADICAL RESEARCH

Unprecedented Inhibition of Hydrocarbon Autoxidation by Diarylamine Radical-Trapping Antioxidants

(2015) Ron Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective

(2014) Keith U. Ingold et al.   CHEMICAL REVIEWS

Singlet molecular oxygen generated by biological hydroperoxides

(2014) Sayuri Miyamoto et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Redox Chemistry of Selenenic Acids and the Insight It Brings on Transition State Geometry in the Reactions of Peroxyl Radicals

(2014) Zosia Zielinski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity

(2014) Donatella Canistro et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Kinetics of ethylbenzene oxy-chemiluminescence in the presence of antioxidants from tissues of the marine invertebrate Eupentacta fraudatrix: Estimating the concentration and reactivity of the natural antioxidants

(2014) R. F. Vasil’ev et al.   KINETICS AND CATALYSIS

Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

(2014) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

3-Pyridinols and 5-pyrimidinols: Tailor-made for use in synergistic radical-trapping co-antioxidant systems

(2013) Luca Valgimigli et al.   Beilstein Journal of Organic Chemistry

Lipid Geometrical Isomerism: From Chemistry to Biology and Diagnostics

(2013) Chryssostomos Chatgilialoglu et al.   CHEMICAL REVIEWS

Multi-faceted Reactivity of Alkyltellurophenols Towards Peroxyl Radicals: Catalytic Antioxidant Versus Thiol-Depletion Effect

(2013) Riccardo Amorati et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antioxidant Activity of Essential Oils

(2013) Riccardo Amorati et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Perspective on Free Radical Autoxidation: The Physical Organic Chemistry of Polyunsaturated Fatty Acid and Sterol Peroxidation

(2013) Ned A. Porter   JOURNAL OF ORGANIC CHEMISTRY

5-S-Lipoylhydroxytyrosol, a Multidefense Antioxidant Featuring a Solvent-Tunable Peroxyl Radical-Scavenging 3-Thio-1,2-dihydroxybenzene Motif

(2013) Riccardo Amorati et al.   JOURNAL OF ORGANIC CHEMISTRY

Lipid oxidation induces structural changes in biomimetic membranes

(2013) Georges Weber et al.   Soft Matter

The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis

(2013) Corinne M. Spickett   Redox Biology

Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses

(2012) Jody C. Ullery et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The Reaction of Sulfenic Acids with Peroxyl Radicals: Insights into the Radical-Trapping Antioxidant Activity of Plant-Derived Thiosulfinates

(2012) Riccardo Amorati et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preparation of Highly Reactive Pyridine- and Pyrimidine-Containing Diarylamine Antioxidants

(2012) Jason J. Hanthorn et al.   JOURNAL OF ORGANIC CHEMISTRY

The Reactivity of Air-Stable Pyridine- and Pyrimidine-Containing Diarylamine Antioxidants

(2012) Jason J. Hanthorn et al.   JOURNAL OF ORGANIC CHEMISTRY

Cytochrome c-promoted cardiolipin oxidation generates singlet molecular oxygen

(2012) Sayuri Miyamoto et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks

(2011) Derek A. Pratt et al.   ACCOUNTS OF CHEMICAL RESEARCH

Formation and Signaling Actions of Electrophilic Lipids

(2011) Francisco J. Schopfer et al.   CHEMICAL REVIEWS

Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild-Type Tumor Protein p53

(2011) Jorge Nieva et al.   CHEMISTRY & BIOLOGY

Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth

(2011) M. Khoobchandani et al.   FITOTERAPIA

Kinetic and thermodynamic aspects of the chain-breaking antioxidant activity of ascorbic acid derivatives in non-aqueous media

(2011) Riccardo Amorati et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: Dose– and time–response studies in female MRL+/+ mice

(2011) Gangduo Wang et al.   TOXICOLOGY

Signaling and cytotoxic functions of 4-hydroxyalkenals

(2010) Yael Riahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

TEMPO reacts with oxygen-centered radicals under acidic conditions

(2010) Riccardo Amorati et al.   CHEMICAL COMMUNICATIONS

Free radical intermediates in the inhibition of the autoxidation reaction

(2010) Marco Lucarini et al.   CHEMICAL SOCIETY REVIEWS

Preparation and Investigation of Vitamin B6-Derived Aminopyridinol Antioxidants

(2010) Remigiusz Serwa et al.   CHEMISTRY-A EUROPEAN JOURNAL

New hypotheses on the pathways of formation of malondialdehyde and isofurans

(2010) Arnold N. Onyango et al.   FREE RADICAL BIOLOGY AND MEDICINE

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

(2010) Wei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-Lasting Antioxidant Protection: A Regenerable BHA Analogue

(2010) Henrik Johansson et al.   JOURNAL OF ORGANIC CHEMISTRY

The Redox Chemistry of Sulfenic Acids

(2010) Alaina J. McGrath et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Base-Promoted Reaction of 5-Hydroxyuracil Derivatives with Peroxyl Radicals

(2010) Riccardo Amorati et al.   ORGANIC LETTERS

Organochalcogen Substituents in Phenolic Antioxidants

(2010) Riccardo Amorati et al.   ORGANIC LETTERS

Facile chemiluminescence assay for antioxidative properties of vegetable lipids: fundamentals and illustrative examples

(2009) Galina F. Fedorova et al.   ANALYST

Unexpected Acid Catalysis in Reactions of Peroxyl Radicals with Phenols

(2009) Luca Valgimigli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis

(2009) Takashi Yamada et al.   ARTHRITIS AND RHEUMATISM

Rate Constants for Peroxidation of Polyunsaturated Fatty Acids and Sterols in Solution and in Liposomes

(2009) Libin Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

(2009) Tae-gyu Nam et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

(2009) K. Usui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unusual Reaction of Semiquinone Radicals with Molecular Oxygen

(2008) Luca Valgimigli et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Chain-Breaking Pyridinol Antioxidants

(2008) Sangit Kumar et al.   ORGANIC LETTERS

Inhibition of myeloperoxidase-mediated protein nitration by tempol: Kinetics, mechanism, and implications

(2008) S. M. Vaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA