Geometrical isomerization of arachidonic acid during lipid peroxidation interferes with ferroptosis

Identification of essential sites of lipid peroxidation in ferroptosis

(2023) A. Nikolai von Krusenstiern et al.   Nature Chemical Biology

Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis

(2023) Yusuke Hirata et al.   CURRENT BIOLOGY

Effects of Oxygen Tension for Membrane Lipidome Remodeling of Cockayne Syndrome Cell Models

(2022) Carla Ferreri et al.   Cells

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin

(2022) Tatsuya Shimada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms

(2021) Takuya Noguchi et al.   Cell Death & Disease

Lipid Metabolism and Ferroptosis

(2021) Ji-Yoon Lee et al.   Biology-Basel

EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol

(2021) Miranda L. Jacobs et al.   BIOPHYSICAL JOURNAL

trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway

(2021) Yusuke Hirata et al.   Scientific Reports

High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

(2021) Yixiang Zhang et al.   Biology Direct

Differential and shared effects of eicosapentaenoic acid and docosahexaenoic acid on serum metabolome in subjects with chronic inflammation

(2021) Wan-Chi Chang et al.   Scientific Reports

Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy

(2021) Caterina Bartolacci et al.   Frontiers in Molecular Biosciences

Reductive Stress of Sulfur-Containing Amino Acids within Proteins and Implication of Tandem Protein–Lipid Damage

(2021) Chryssostomos Chatgilialoglu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop

(2020) Yusuke Hirata et al.   Scientific Reports

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

(2020) Kaylyn D. Tousignant et al.   Cancer & Metabolism

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Fatty Acid Remodeling of Membrane Glycerophospholipids Induced by Bleomycin and Iron Oxide Nanoparticles in Human Embryonic Kidney Cells

(2020) Marios G. Krokidis et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease

(2020) Morgan K. Foret et al.   CHEMICAL REVIEWS

Dietary fatty acids fine-tune Piezo1 mechanical response

(2019) Luis O. Romero et al.   Nature Communications

Hexadecenoic Fatty Acid Positional Isomers and De Novo PUFA Synthesis in Colon Cancer Cells

(2019) Roberta Scanferlato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Trans Lipid Library: Synthesis of Docosahexaenoic Acid (DHA) Monotrans Isomers and Regioisomer Identification in DHA-Containing Supplements

(2018) Georgia Menounou et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of 5-trans Isomer of Arachidonic Acid on Model Liposomal Membranes Studied by a Combined Simulation and Experimental Approach

(2018) Ioanna Tremi et al.   JOURNAL OF MEMBRANE BIOLOGY

Arachidonic acid: Physiological roles and potential health benefits – A review

(2018) Hatem Tallima et al.   Journal of Advanced Research

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women

(2017) A Manni et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

The Reaction of Thiyl Radical with Methyl Linoleate: Completing the Picture

(2017) Chryssostomos Chatgilialoglu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of bleomycin and antioxidants on the fatty acid profile of testicular cancer cell membranes

(2016) A. Cort et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The influence of antioxidants in the thiyl radical induced lipid peroxidation and geometrical isomerization in micelles of linoleic acid

(2016) Ivana Tartaro Bujak et al.   FREE RADICAL RESEARCH

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Endogenous formation of trans fatty acids: Health implications and potential dietary intervention

(2016) Wei-Lun Hung et al.   Journal of Functional Foods

State of the art paper Potential role of dietary lipids in the prophylaxis of some clinical conditions

(2015) Urvashi Bhagat et al.   Archives of Medical Science

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Lipid Geometrical Isomerism: From Chemistry to Biology and Diagnostics

(2013) Chryssostomos Chatgilialoglu et al.   CHEMICAL REVIEWS

Effects of Elaidic Acid on Lipid Metabolism in HepG2 Cells, Investigated by an Integrated Approach of Lipidomics, Transcriptomics and Proteomics

(2013) Lone Vendel Nielsen et al.   PLoS One

trans Arachidonic acid isomers inhibit NADPH-oxidase activity by direct interaction with enzyme components

(2012) H. Souabni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Trans Fatty Acids: Chemical Synthesis of Eicosapentaenoic Acid Isomers and Detection in Rats Fed a Deodorized Fish Oil Diet

(2012) Carla Ferreri et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools

(2012) Carla Ferreri et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols

(2011) Branka Mihaljević et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Comparative effects of DHA and EPA on cell function

(2009) Renata Gorjão et al.   PHARMACOLOGY & THERAPEUTICS

Trans-arachidonic acids: new mediators of nitro-oxidative stress

(2008) Michael Balazy et al.   PHARMACOLOGY & THERAPEUTICS