PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity

(2023) Xiao-Meng Liu et al.   Journal of Medicinal Chemistry

Strategies for designing proteolysis targeting chimaeras (PROTACs)

(2022) Shipeng He et al.   MEDICINAL RESEARCH REVIEWS

An update of label-free protein target identification methods for natural active products

(2022) Zhao Cui et al.   Theranostics

Discovery of novel bis-evodiamine derivatives with potent antitumor activity

(2022) Huixin Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Evodiamine Derivatives as Potential Antihepatocellular Carcinoma Agents

(2022) Fang Lei et al.   JOURNAL OF MEDICINAL CHEMISTRY

PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids

(2022) Yanli Wu et al.   Acta Pharmaceutica Sinica B

Recent Advances in PROTACs for Drug Targeted Protein Research

(2022) Tingting Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug discovery inspired by bioactive small molecules from nature

(2022) Seyun Kim et al.   Animal Cells and Systems

Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

(2022) Junfei Cheng et al.   Journal of Medicinal Chemistry

Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents

(2021) Zonglin Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aptamer–PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

(2021) Shipeng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis and bioactivity study of evodiamine derivatives as multifunctional agents for the treatment of hepatocellular carcinoma

(2021) Xiaohong Fan et al.   BIOORGANIC CHEMISTRY

Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound

(2021) Shuqiang Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The expression and prognostic value of REXO4 in hepatocellular carcinoma

(2021) Weipeng Chen et al.   Journal of Gastrointestinal Oncology

Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer

(2021) Shengtao Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Synthesis, Structural Modification and Mode of Anticancer Action of Evodiamine: a review

(2021) Meixia Fan et al.   Recent Patents on Anti-Cancer Drug Discovery

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

(2021) Ying Wu et al.   Acta Pharmaceutica Sinica B

REXO4 acts as a biomarker and promotes hepatocellular carcinoma progression

(2021) Yun Ruan et al.   Journal of Gastrointestinal Oncology

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer

(2020) Junfei Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Network Analysis of miRNA and mRNA Changes in the Prelimbic Cortex of Rats With Chronic Neuropathic Pain: Pointing to Inflammation

(2020) Guohong Cai et al.   Frontiers in Genetics

Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges

(2020) Shenxin Zeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

(2020) Shipeng He et al.   Acta Pharmaceutica Sinica B

Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

(2019) Yahui Huang et al.   Acta Pharmaceutica Sinica B

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer

(2019) Lei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiproliferative hydrogen sulfide releasing evodiamine derivatives and their apoptosis inducing properties

(2018) Xu Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

(2018) Jinlei Bian et al.   BIOORGANIC CHEMISTRY

Recent advances in target identification of bioactive natural products

(2018) Minoru Yoshida   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The structural modification of natural products for novel drug discovery

(2016) Hong Yao et al.   Expert Opinion on Drug Discovery

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)

(2016) Jonathan B. Baell   JOURNAL OF NATURAL PRODUCTS

Target identification of natural products and bioactive compounds using affinity-based probes

(2016) Sijun Pan et al.   NATURAL PRODUCT REPORTS

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cells

(2015) Nirmala Krishnamurthy et al.   CANCER BIOLOGY & THERAPY

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

(2015) Shengzheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prime time for PROTACs

(2015) Raymond J Deshaies   Nature Chemical Biology

Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors

(2015) Shipeng He et al.   ACS Medicinal Chemistry Letters

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Chemo- and site-selective derivatizations of natural products enabling biological studies

(2014) Omar Robles et al.   NATURAL PRODUCT REPORTS

Natural product and natural product derived drugs in clinical trials

(2014) Mark S. Butler et al.   NATURAL PRODUCT REPORTS

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological Actions of Multi-Target-Directed Evodiamine

(2013) Hui Yu et al.   MOLECULES

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

(2012) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites

(2011) N Krishnamurthy et al.   ONCOGENE

Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents

(2010) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Development of an Aryl Hydrocarbon Receptor Antagonist Using the Proteolysis-Targeting Chimeric Molecules Approach: A Potential Tool for Chemoprevention

(2008) D. Puppala et al.   MOLECULAR PHARMACOLOGY