Chemo- and site-selective derivatizations of natural products enabling biological studies

Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

(2013) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Tailoring of Teicoplanin with Site-Selective Reactions

(2013) Tejas P. Pathak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis at a Distance: Catalytic, Site-Selective Phosphorylation of Teicoplanin

(2013) Sunkyu Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioconjugation by Native Chemical Tagging of C–H Bonds

(2013) Qianghui Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Catalyst recognition of cis-1,2-diols enables site-selective functionalization of complex molecules

(2013) Xixi Sun et al.   Nature Chemistry

Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate

(2013) Jing Li et al.   Nature Chemistry

An Approach to the Site-Selective Deoxygenation of Hydroxy Groups Based on Catalytic Phosphoramidite Transfer

(2012) Peter A. Jordan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Site-Selective Bromination of Vancomycin

(2012) Tejas P. Pathak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Site-Selective Thiocarbonylations and Deoxygenations of Vancomycin Reveal Hydroxyl-Dependent Conformational Effects

(2012) Brandon S. Fowler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

(2012) Justin S. Cisar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Selective transformations of complex molecules are enabled by aptameric protective groups

(2012) Andreas A. Bastian et al.   Nature Chemistry

Electronic tuning of site-selectivity

(2012) Brandon C. Wilcock et al.   Nature Chemistry

Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation

(2012) Phillip A. Lichtor et al.   Nature Chemistry

Cyclopropanations of Olefin-Containing Natural Products for Simultaneous Arming and Structure Activity Studies

(2012) Omar Robles et al.   ORGANIC LETTERS

Adding Aliphatic C-H Bond Oxidations to Synthesis

(2012) M. C. White   SCIENCE

Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural ProductsviaO–H Insertion

(2011) Supakarn Chamni et al.   ACS Chemical Biology

Selective Molecular Sequestration with Concurrent Natural Product Functionalization and Derivatization: From Crude Natural Product Extracts to a Single Natural Product Derivative in One Step

(2011) Viktor Krchňák et al.   JOURNAL OF ORGANIC CHEMISTRY

Storable Arylpalladium(II) Reagents for Alkene Labeling in Aqueous Media

(2011) Rebecca L. Simmons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organic synthesis toward small-molecule probes and drugs

(2011) S. L. Schreiber   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Aiming for the Ideal Synthesis

(2010) Tanja Gaich et al.   JOURNAL OF ORGANIC CHEMISTRY

Silver-Catalyzed Late-Stage Fluorination

(2010) Pingping Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the potential of natural products in the discovery of pharma leads: A case for reassessment

(2010) Samuel Danishefsky   NATURAL PRODUCT REPORTS

Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

(2010) James J. La Clair   NATURAL PRODUCT REPORTS

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Mild Arming and Derivatization of Natural Products via an In(OTf)3-Catalyzed Arene Iodination

(2010) Cong-Ying Zhou et al.   ORGANIC LETTERS

Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation

(2010) M. S. Chen et al.   SCIENCE

Chemoselectivity: The Mother of Invention in Total Synthesis

(2009) Ryan A. Shenvi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Redox Economy in Organic Synthesis

(2009) Noah Z. Burns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The economies of synthesis

(2009) Timothy Newhouse et al.   CHEMICAL SOCIETY REVIEWS

An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts

(2009) Chad A. Lewis et al.   JOURNAL OF NATURAL PRODUCTS

Understanding the Differential Performance of Rh2(esp)2as a Catalyst for C−H Amination

(2009) David N. Zalatan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protecting-group-free synthesis as an opportunity for invention

(2009) Ian S. Young et al.   Nature Chemistry

Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels–Alder reactions

(2009) Baiyuan Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Syntheses and Biological Activity Studies of Novel Sterol Analogs from Nitroso Diels−Alder Reactions of Ergosterol

(2009) Baiyuan Yang et al.   ORGANIC LETTERS

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bright Ideas for Chemical Biology

(2008) Luke D. Lavis et al.   ACS Chemical Biology

Site-Selective Catalysis of Phenyl Thionoformate Transfer as a Tool for Regioselective Deoxygenation of Polyols

(2008) María Sánchez-Roselló et al.   JOURNAL OF ORGANIC CHEMISTRY

Evolution of Natural Product Scaffolds by Acyl- and Arylnitroso Hetero-Diels−Alder Reactions: New Chemistry on Piperine

(2008) Viktor Krchňák et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE

Challenges for the 'chemical-systems' biologist

(2008) Gabriel M Simon et al.   Nature Chemical Biology

Benzothiadiazoyl-triazoyl cyclodextrin: a selective fluoroionophore for Ni(II)

(2008) Stephane Maisonneuve et al.   TETRAHEDRON

Solid-Supported Nitroso Hetero Diels–Alder Reactions. 2. Arylnitroso Dienophiles: Scope and Limitations

(2007) Viktor Krchňák et al.   JOURNAL OF COMBINATORIAL CHEMISTRY