Target identification of natural products and bioactive compounds using affinity-based probes

A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

(2015) Lin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alternative One-Pot Synthesis of (Trifluoromethyl)phenyldiazirines from Tosyloxime Derivatives: Application for New Synthesis of Optically Pure Diazirinylphenylalanines for Photoaffinity Labeling

(2015) Lei Wang et al.   ORGANIC LETTERS

Multiplex Imaging and Cellular Target Identification of Kinase Inhibitors via an Affinity-Based Proteome Profiling Approach

(2015) Ying Su et al.   Scientific Reports

“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling

(2014) Zhengqiu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric regulation of  -secretase activity by a phenylimidazole-type  -secretase modulator

(2014) K. Takeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes

(2013) Kyeong Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

(2013) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photo-induced covalent cross-linking for the analysis of biomolecular interactions

(2013) George W. Preston et al.   CHEMICAL SOCIETY REVIEWS

Cell-Based Proteome Profiling Using an Affinity-Based Probe (AfBP) Derived from 3-Deazaneplanocin A ()

(2013) Eric K. W. Tam et al.   Chemistry-An Asian Journal

Target identification of biologically active small molecules via in situ methods

(2013) Ying Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Inhibition of Microtubule Assembly by a Complex of Actin and Antitumor Macrolide Aplyronine A

(2013) Masaki Kita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

Affinity-Based Probes Based on Type II Kinase Inhibitors

(2012) Pratistha Ranjitkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interactions of the Antitumor Macrolide Aplyronine A with Actin and Actin-Related Proteins Established by Its Versatile Photoaffinity Derivatives

(2012) Masaki Kita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active site profiling reveals coupling between domains in SRC-family kinases

(2012) Ratika Krishnamurty et al.   Nature Chemical Biology

Diazirine based photoaffinity labeling

(2011) Luba Dubinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells

(2011) Jürgen Eirich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor

(2010) Kalinka Koteva et al.   Nature Chemical Biology

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

(2008) Benjamin J. Leslie et al.   CHEMICAL SOCIETY REVIEWS