Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

Targeted protein degraders crowd into the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

(2021) Shipeng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PROTACs: A novel strategy for cancer therapy

(2020) Jing Liu et al.   SEMINARS IN CANCER BIOLOGY

Small-molecule PROTACs: novel agents for cancer therapy

(2020) Yichao Wan et al.   Future Medicinal Chemistry

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

(2020) Yonghan He et al.   Journal of Hematology & Oncology

Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer

(2020) Junfei Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

NAMPT: A potential prognostic and therapeutic biomarker in patients with glioblastoma

(2019) Qiuyun Guo et al.   ONCOLOGY REPORTS

Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide

(2019) Ying Wu et al.   ACS Medicinal Chemistry Letters

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

(2017) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted protein degradation by PROTACs

(2017) Taavi K. Neklesa et al.   PHARMACOLOGY & THERAPEUTICS

Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery

(2017) Wei Chen et al.   ACS Medicinal Chemistry Letters

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase

(2016) Wei Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities

(2016) Hang Chen et al.   Expert Review of Anticancer Therapy

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

(2016) Kanak Raina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological and pathophysiological roles of NAMPT and NAD metabolism

(2015) Antje Garten et al.   Nature Reviews Endocrinology

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer

(2015) Deepak Sampath et al.   PHARMACOLOGY & THERAPEUTICS

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT

(2015) Xia Wang et al.   Scientific Reports

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

(2015) Tian-Ying Xu et al.   Scientific Reports

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

(2013) Ubaldina Galli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY