Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents

Structural Simplification of Natural Products

(2019) Shengzheng Wang et al.   CHEMICAL REVIEWS

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer

(2019) Lei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections

(2018) Yahui Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel fluorescent probes of 10-hydroxyevodiamine: Autophagy and apoptosis-inducing anticancer mechanisms

(2018) Shuqiang Chen et al.   Acta Pharmaceutica Sinica B

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

(2017) Ying-Ren Wang et al.   NUCLEIC ACIDS RESEARCH

The structural modification of natural products for novel drug discovery

(2016) Hong Yao et al.   Expert Opinion on Drug Discovery

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Insights into drug discovery from natural products through structural modification

(2015) Jichao Chen et al.   FITOTERAPIA

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

(2015) Shengzheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural product and natural product derived drugs in clinical trials

(2014) Mark S. Butler et al.   NATURAL PRODUCT REPORTS

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pharmacological Actions of Multi-Target-Directed Evodiamine

(2013) Hui Yu et al.   MOLECULES

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

(2012) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells

(2010) J. Lee et al.   CARCINOGENESIS

Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents

(2010) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

A mild and efficient route to 2-benzyl tryptamine derivatives via ring-opening of β-carbolines

(2008) Fariza Hadjaz et al.   TETRAHEDRON