Capsaicinoids and Their Effects on Cancer: The “Double-Edged Sword” Postulate from the Molecular Scale

Capsaicin encapsulated in W/O/W double emulsions fabricated via ethanol-induced pectin gelling: Improvement of bioaccessibility and reduction of irritation

(2023) Jingxing He et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Identification and expression analysis of capsaicin biosynthesis pathway genes at genome level in Capsicum chinense

(2022) Wei Zhang et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells

(2022) Jogendra S. Pawar et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

(2022) Tomi Lois Adetunji et al.   Frontiers in Oncology

Mitochondrial activities play a pivotal role in regulating cell cycle in response to doxorubicin

(2021) Ken Dornfeld et al.   CELL CYCLE

BECLIN1: Protein Structure, Function and Regulation

(2021) Sharon Tran et al.   Cells

Comprehensive understanding of multiple actions of anticancer drug tamoxifen in isolated mitochondria

(2021) Yufu Unten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nitrogen Source Affects the Composition of Metabolites in Pepper (Capsicum annuum L.) and Regulates the Synthesis of Capsaicinoids through the GOGAT–GS Pathway

(2020) Jing Zhang et al.   Foods

A single TRPV1 amino acid controls species sensitivity to capsaicin

(2020) Ying Chu et al.   Scientific Reports

Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA)

(2019) Atikul Islam et al.   Cells

Properties of capsaicin and its utility in veterinary and human medicine

(2018) Łukasz Adaszek et al.   RESEARCH IN VETERINARY SCIENCE

Phytochemicals in Capsicum oleoresin from different varieties of hot chilli peppers with their antidiabetic and antioxidant activities due to some phenolic compounds

(2017) Phitchan Sricharoen et al.   ULTRASONICS SONOCHEMISTRY

The Association of Hot Red Chili Pepper Consumption and Mortality: A Large Population-Based Cohort Study

(2017) Mustafa Chopan et al.   PLoS One

Synergistic complex from plants Solanaceae exhibits cytotoxicity for the human hepatocellular carcinoma cell line HepG2

(2016) Romina Schwarzlin et al.   BMC Complementary and Alternative Medicine

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

NK cell education via nonclassical MHC and non-MHC ligands

(2016) Yuke He et al.   Cellular & Molecular Immunology

In vivo and in vitro evaluation for nutraceutical purposes of capsaicin, capsanthin, lutein and four pepper varieties

(2016) Zahira Fernández-Bedmar et al.   FOOD AND CHEMICAL TOXICOLOGY

Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory EffectsIn Vivoand Inhibit the Production of TNF-α and NOIn Vitro

(2016) Alexandra Allemand et al.   JOURNAL OF MEDICINAL FOOD

Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)

(2016) Ming-Hung Lin et al.   MOLECULES

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

(2016) Victor Fattori et al.   MOLECULES

Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases

(2016) Shaherin Basith et al.   MOLECULES

Effect of the Capsicoside G-rich Fraction from Pepper (Capsicum annuumL.) Seeds on High-fat Diet-induced Obesity in Mice

(2016) Jeehye Sung et al.   PHYTOTHERAPY RESEARCH

Biochemical characterization and immunolocalization studies of a Capsicum chinense Jacq. protein fraction containing DING proteins and anti-microbial activity

(2016) Ligia Brito-Argáez et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Update on a tumor-associated NADH oxidase in gastric cancer cell growth

(2016) Hsiao-Ling Cheng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Discovery of putative capsaicin biosynthetic genes by RNA-Seq and digital gene expression analysis of pepper

(2016) Zi-Xin Zhang et al.   Scientific Reports

Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells - Elucidating the Role of p53

(2015) Arnab Sarkar et al.   Asian Pacific Journal of Cancer Prevention

Silencing AT3 gene reduces the expression of pAmt, BCAT, Kas, and Acl genes involved in capsaicinoid biosynthesis in chili pepper fruits

(2015) M. L. Arce-Rodríguez et al.   BIOLOGIA PLANTARUM

Role of Autophagy in Capsaicin-Induced Apoptosis in U251 Glioma Cells

(2015) Ya-Ping Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

(2015) Krishnapura Srinivasan   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Aflatoxin B1and aflatoxins in ground red chilli pepper after drying

(2015) Ali Özkan et al.   Food Additives & Contaminants Part B-Surveillance

Antioxidant activity and protective effects against oxidative damage of human cells induced by X-radiation of phenolic glycosides isolated from pepper fruits Capsicum annuum L.

(2015) Małgorzata Materska et al.   FOOD CHEMISTRY

Isolation and structural features of an antiradical polysaccharide of Capsicum annuum that interacts with BSA

(2015) Sujay Kumar Majee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death

(2015) Yi-Hui Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In the shadow of a pepper-centric historiography: Understanding the global diffusion of capsicums in the sixteenth and seventeenth centuries

(2015) Stefan Halikowski Smith   JOURNAL OF ETHNOPHARMACOLOGY

Plants used in the traditional medicine of Mesoamerica (Mexico and Central America) and the Caribbean for the treatment of obesity

(2015) Angel Josabad Alonso-Castro et al.   JOURNAL OF ETHNOPHARMACOLOGY

Morpho-structural description of epidermal tissues related to pungency of Capsicum species

(2015) L. Sánchez-Segura et al.   JOURNAL OF FOOD ENGINEERING

Quantum dot nanoprobe-based high-content monitoring of notch pathway inhibition of breast cancer stem cell by capsaicin

(2015) Yumi Shim et al.   MOLECULAR AND CELLULAR PROBES

Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells

(2015) LONG ZHENG et al.   Molecular Medicine Reports

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

(2015) Hao-Jui Weng et al.   NEURON

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91

(2015) Maria Saveria Gilardini Montani et al.   NUTRITION

RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress

(2015) N Kanu et al.   ONCOGENE

Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

(2015) Éva Sághy et al.   PHARMACOLOGICAL RESEARCH

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression

(2015) Marisa Granato et al.   Oncotarget

The N-cadherin cytoplasmic domain confers anchorage-independent growth and the loss of contact inhibition

(2015) Masayuki Ozawa   Scientific Reports

Consumption of spicy foods and total and cause specific mortality: population based cohort study

(2015) Jun Lv et al.   BMJ-British Medical Journal

Consumption of spicy foods and total and cause specific mortality: population based cohort study

(2015) Jun Lv et al.   BMJ-British Medical Journal

Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway

(2014) Jamie K. Lau et al.   APOPTOSIS

Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner

(2014) Seon Hee Oh et al.   Autophagy

Attenuation of natural killer cell functions by capsaicin through a direct and TRPV1-independent mechanism

(2014) Hun Sik Kim et al.   CARCINOGENESIS

Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration

(2014) C L Buchheit et al.   CELL DEATH AND DIFFERENTIATION

Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53

(2014) Junzhe Jin et al.   International Journal of Biological Sciences

ZO Proteins Redundantly Regulate the Transcription Factor DbpA/ZONAB

(2014) Domenica Spadaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis

(2014) Kelsey J. Weigel et al.   MOLECULAR CANCER RESEARCH

CBP-Mediated FOXO-1 Acetylation Inhibits Pancreatic Tumor Growth by Targeting SirT

(2014) K. C. Pramanik et al.   MOLECULAR CANCER THERAPEUTICS

Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum species

(2014) Seungill Kim et al.   NATURE GENETICS

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Gene-Specific Polymorphisms and Association with Capsaicin Pathway Metabolites in Capsicum annuum L. Collections

(2014) Umesh K. Reddy et al.   PLoS One

The Selective Target of Capsaicin on FASN Expression and De Novo Fatty Acid Synthesis Mediated through ROS Generation Triggers Apoptosis in HepG2 Cells

(2014) Hathaichanok Impheng et al.   PLoS One

Regulations of capsaicin synthesis in Capsicum annuum L. by Penicillium resedanum LK6 during drought conditions

(2014) Abdul Latif Khan et al.   SCIENTIA HORTICULTURAE

Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells

(2014) Ogunc Meral et al.   TUMOR BIOLOGY

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells

(2014) Ying-Li Hu et al.   Scientific Reports

Capsaicin as an inducer of damage-associated molecular patterns (DAMPs) of immunogenic cell death (ICD) in human bladder cancer cells

(2013) Donatella D’Eliseo et al.   CELL STRESS & CHAPERONES

Capsaicin induces cytotoxicity in pancreatic neuroendocrine tumor cells via mitochondrial action

(2013) M. Skrzypski et al.   CELLULAR SIGNALLING

Isolation and Analysis of Bioactive Compounds inCapsicumPeppers

(2013) L. Asnin et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Capsaicin and Its Analogues: Structure-Activity Relationship Study

(2013) X.-F. Huang et al.   CURRENT MEDICINAL CHEMISTRY

Mechanisms and clinical uses of capsaicin

(2013) Surinder Kumar Sharma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice

(2013) P. Anandakumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Secondary Metabolites of Capsicum Species and Their Importance in the Human Diet

(2013) Yuni Wahyuni et al.   JOURNAL OF NATURAL PRODUCTS

Antioxidant and hypoglycaemic activities and their relationship to phytochemicals in Capsicum annuum cultivars during fruit development

(2013) Rosa Tundis et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent

(2013) F M Davis et al.   ONCOGENE

Fruit specific variability in capsaicinoid accumulation and transcription of structural and regulatory genes in Capsicum fruit

(2013) Neda Keyhaninejad et al.   PLANT SCIENCE

Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer

(2013) B Liu et al.   Cell Death & Disease

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption

(2012) Titia E. Woudenberg-Vrenken et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein

(2012) Yu-Ching Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Tumor macrophages as a target for Capsaicin mediated immunotherapy

(2012) Amiya K. Ghosh et al.   CANCER LETTERS

Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells

(2012) Zih-Ming Zeng et al.   EXPERIMENTAL CELL RESEARCH

Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: A host and environment interaction in gastric cancer

(2012) Lizbeth López-Carrillo et al.   FOOD AND CHEMICAL TOXICOLOGY

Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model

(2012) P. Anandakumar et al.   INFLAMMATION RESEARCH

Capsaicin induces cycle arrest by inhibiting cyclin-dependent-kinase in bladder carcinoma cells

(2012) Dong Chen et al.   INTERNATIONAL JOURNAL OF UROLOGY

Capsaicin-Mediated tNOX (ENOX2) Up-regulation Enhances Cell Proliferation and Migration in Vitro and in Vivo

(2012) Nei-Chi Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

(2012) Keith Bley et al.   TOXICOLOGIC PATHOLOGY

The Two Faces of Capsaicin

(2011) A. M. Bode et al.   CANCER RESEARCH

Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells

(2011) Sara Caprodossi et al.   CARCINOGENESIS

Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice

(2011) H. Bai et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Down-Regulation of Tumor-Associated NADH Oxidase, tNOX (ENOX2), Enhances Capsaicin-Induced Inhibition of Gastric Cancer Cell Growth

(2011) His-Ming Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

FAS-Associated Factor 1 (FAF1): Diverse functions and implications for oncogenesis

(2011) Craig W. Menges et al.   CELL CYCLE

Antioxidant and anti-inflammatory properties of Capsicum baccatum: From traditional use to scientific approach

(2011) Aline Rigon Zimmer et al.   JOURNAL OF ETHNOPHARMACOLOGY

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

(2011) Seong-Ho Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Capsaicin Induces Apoptosis of Cisplatin-Resistant Stomach Cancer Cells by Causing Degradation of Cisplatin-Inducible Aurora-A Protein

(2011) Hui-Chung Huh et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: Variation in health-related compounds and implications for breeding

(2011) Yuni Wahyuni et al.   PHYTOCHEMISTRY

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

(2011) Kartick C. Pramanik et al.   PLoS One

The Insulin-Like Growth Factor Receptor I Promotes Motility and Invasion of Bladder Cancer Cells through Akt- and Mitogen-Activated Protein Kinase-Dependent Activation of Paxillin

(2010) David Metalli et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines

(2010) Cheol-Hee Choi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and Colo 205 Tumor Xenografts in Vivo

(2010) Hsu-Feng Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Naga chilli: A potential source of capsaicinoids with broad-spectrum ethnopharmacological applications

(2010) M.K. Meghvansi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Cancer type-specific tNOX isoforms: A putative family of redox protein splice variants with cancer diagnostic and prognostic potential

(2009) D. James Morré et al.   BIOFACTORS

Effect of Ccapsaicin on tNOX (ENOX2) protein expression in stomach cancer cells

(2009) Hsi-Ming Wang et al.   BIOFACTORS

Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis

(2009) Amiya K. Ghosh et al.   CANCER LETTERS

Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation

(2009) Jin Yeop Kim et al.   CARCINOGENESIS

Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner

(2009) C. Amantini et al.   CARCINOGENESIS

Lysosomal abnormalities during benzo(a)pyrene-induced experimental lung carcinogenesis - defensive role of capsaicin

(2009) P. Anandakumar et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Endoplasmic Reticulum Stress-Mediated Autophagy/Apoptosis Induced by Capsaicin (8-Methyl-N-vanillyl-6-nonenamide) and Dihydrocapsaicin is Regulated by the Extent of c-Jun NH2-Terminal Kinase/Extracellular Signal-Regulated Kinase Activation in WI38 Lung Epithelial Fibroblast Cells

(2009) S.-H. Oh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacology of Vanilloid Transient Receptor Potential Cation Channels

(2009) J. Vriens et al.   MOLECULAR PHARMACOLOGY

Effect of capsaicin on glucose metabolism studied in experimental lung carcinogenesis

(2009) P. Anandakumar et al.   NATURAL PRODUCT RESEARCH

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

A Dynamic Interface for Capsaicinoid Systems Biology

(2009) M. Mazourek et al.   PLANT PHYSIOLOGY

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

(2008) Ruifen Zhang et al.   APOPTOSIS

Early developmental expression of a normally tumor-associated and drug-inhibited cell surface-located NADH oxidase (ENOX2) in non-cancer cells

(2008) NaMi Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Stress-induced down-regulation of tumor-associated NADH oxidase during apoptosis in transformed cells

(2008) Liang-Chi Mao et al.   FEBS LETTERS

Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells

(2008) M CIRONE et al.   IMMUNOLOGY LETTERS

Chili Pepper Fruits: Presumed Precursors of Fatty Acids Characteristic for Capsaicinoids

(2008) Roland Thiele et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis

(2008) P. Anandakumar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac

(2007) Shan-Chi Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL