G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk

(2023) Maria J Forteza et al.   CARDIOVASCULAR RESEARCH

SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

(2023) Teresa Villanueva-Carmona et al.   Cell Metabolism

Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

(2023) Leticia Soriano-Baguet et al.   Cell Reports

Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD

(2023) Anna Marsal-Beltran et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction

(2022) Xiao Tang et al.   ALLERGY

Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis

(2022) Jingwen Xu et al.   Frontiers in Immunology

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

(2022) Prakash Doddapattar et al.   CIRCULATION RESEARCH

Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall

(2022) Maria J. Forteza et al.   CLINICAL SCIENCE

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

(2022) et al.   SCIENCE

Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release

(2022) Rafael I. Jaén et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms

(2022) Shunsuke Katsuki et al.   CIRCULATION RESEARCH

Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis

(2021) Bo Yang et al.   ACS Omega

Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults

(2021) Francisco J. Osuna-Prieto et al.   Cardiovascular Diabetology

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Protective succinate-SUCNR1 metabolic stress signaling gone bad

(2021) Sally Winther et al.   Cell Metabolism

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

(2021) Mette Trauelsen et al.   Cell Reports

Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

(2021) Roland Baumgartner et al.   Metabolites

Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets

(2021) Wei Feng Ma et al.   ATHEROSCLEROSIS

Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer

(2021) Miaomiao Huo et al.   Frontiers in Cell and Developmental Biology

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Hyperlipidemia does not affect development of elastase-induced abdominal aortic aneurysm in mice

(2020) Joscha Mulorz et al.   ATHEROSCLEROSIS

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

(2020) Huize Pan et al.   CIRCULATION

GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses

(2020) Xinyi Li et al.   FASEB JOURNAL

Colchicine in Patients with Chronic Coronary Disease

(2020) Stefan M. Nidorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

(2020) Jeroen Baardman et al.   Nature Communications

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

(2019) Daniel F J Ketelhuth et al.   CARDIOVASCULAR RESEARCH

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr−/− mice

(2019) Martin Berg et al.   CARDIOVASCULAR RESEARCH

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease

(2018) Carlota Recio et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques

(2018) Lukas Tomas et al.   EUROPEAN HEART JOURNAL

PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis

(2018) Silin Lü et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

(2018) Ludivine Laurans et al.   NATURE MEDICINE

PCSK9 induces a pro-inflammatory response in macrophages

(2018) Chiara Ricci et al.   Scientific Reports

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

(2018) José Tuñón et al.   CARDIOVASCULAR RESEARCH

Succinate receptor mediates intestinal inflammation and fibrosis

(2018) Dulce C. Macias-Ceja et al.   Mucosal Immunology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial metabolites: undercover signalling molecules

(2017) Christian Frezza   Interface Focus

GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice

(2016) T. Rubić-Schneider et al.   ALLERGY

GPR91: expanding the frontiers of Krebs cycle intermediates

(2016) Matheus de Castro Fonseca et al.   Cell Communication and Signaling

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

(2016) William Herrington et al.   CIRCULATION RESEARCH

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice

(2016) Swapnil V. Shewale et al.   JOURNAL OF LIPID RESEARCH

Metabolic Regulation of Histone Post-Translational Modifications

(2015) Jing Fan et al.   ACS Chemical Biology

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe−/− mice

(2015) Konstantinos A. Polyzos et al.   CARDIOVASCULAR RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

(2014) Martin Mæng Bjørklund et al.   CIRCULATION RESEARCH

Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

(2014) Kenneth J. McCreath et al.   DIABETES

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis

(2014) Shinobu Miyazaki-Anzai et al.   PLoS One

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice

(2012) Lei Zhang et al.   EUROPEAN HEART JOURNAL

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY