GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses

Succinate‐GPR‐91 receptor signalling is responsible for nonalcoholic steatohepatitis‐associated fibrosis: Effects of DHA supplementation

(2020) Xue‐Jing Liu et al.   LIVER INTERNATIONAL

Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?

(2019) Xiang-Nan Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Plethora of functions packed into 45 kDa arrestins: biological implications and possible therapeutic strategies

(2019) Vsevolod V. Gurevich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural basis of species-selective antagonist binding to the succinate receptor

(2019) Matthias Haffke et al.   NATURE

Role of GPCR signaling and calcium dysregulation in Alzheimer's disease

(2019) Sushma et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

GPCR signaling: conformational activation of arrestins

(2018) Alem W. Kahsai et al.   CELL RESEARCH

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

(2018) André L. Saraiva et al.   FASEB JOURNAL

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

(2018) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Arrestins as rheostats of GPCR signalling

(2018) J. Silvio Gutkind et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Diversity in the G Protein-Coupled Receptor Superfamily

(2018) Márton Vass et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

(2018) Po-Lin Tseng et al.   Scientific Reports

Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis

(2018) Eun-Hee Cho   Frontiers in Endocrinology

Succinate receptor mediates intestinal inflammation and fibrosis

(2018) Dulce C. Macias-Ceja et al.   Mucosal Immunology

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

(2017) Darren M. Riddy et al.   PHARMACOLOGICAL REVIEWS

Succinate: An initiator in tumorigenesis and progression

(2017) Ting Zhao et al.   Oncotarget

Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation

(2017) Xianmin Mu et al.   Oncotarget

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

(2017) Mette Trauelsen et al.   Molecular Metabolism

Role of mitochondrial dysfunction in cancer progression

(2016) Chia-Chi Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells

(2016) Ying Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G Protein–Coupled Receptor-G–Proteinβγ–Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure

(2016) Fadia A. Kamal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Insight into SUCNR1 (GPR91) structure and function

(2016) Julie Gilissen et al.   PHARMACOLOGY & THERAPEUTICS

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma

(2016) Jian Wu   Oncotarget

G Protein-Coupled Receptors (GPCRs) in Alzheimer’s Disease: A Focus on BACE1 Related GPCRs

(2016) Juan Zhao et al.   Frontiers in Aging Neuroscience

Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions

(2016) Sandra Favret et al.   Aging-US

Forskolin-free cAMP assay for Gi-coupled receptors

(2015) Julie Gilissen et al.   BIOCHEMICAL PHARMACOLOGY

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

(2015) Tuomas Laukka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two disparate ligand-binding sites in the human P2Y1 receptor

(2015) Dandan Zhang et al.   NATURE

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

(2014) Kenneth J. McCreath et al.   DIABETES

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

(2014) Johannes Schmitt et al.   LIVER INTERNATIONAL

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91

(2013) Jianyan Hu et al.   EXPERIMENTAL EYE RESEARCH

Succinate receptor GPR91, a Gαicoupled receptor that increases intracellular calcium concentrations through PLCβ

(2013) Linda Sundström et al.   FEBS LETTERS

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

(2012) Xiao-long Tang et al.   ACTA PHARMACOLOGICA SINICA

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

Cardiovascular Risk Assessment of the Liver Transplant Candidate

(2011) Zankhana Raval et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Succinate independently stimulates full platelet activation via cAMP and phosphoinositide 3-kinase-β signaling

(2010) C. HÖGBERG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway

(2009) Carla J. Aguiar et al.   CELL CALCIUM

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells

(2009) Joris H. Robben et al.   KIDNEY INTERNATIONAL

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation

(2008) Chi Shing Sum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-alcoholic fatty liver disease: The mist gradually clears

(2008) Nimantha Mark Wilfred de Alwis et al.   JOURNAL OF HEPATOLOGY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE