PCSK9 induces a pro-inflammatory response in macrophages

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

(2017) Sophie J. Bernelot Moens et al.   EUROPEAN HEART JOURNAL

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study

(2017) Massimiliano Ruscica et al.   Journal of the American Heart Association

Liver fat accumulation is associated with circulating PCSK9

(2016) Massimiliano Ruscica et al.   ANNALS OF MEDICINE

PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement

(2016) Nicola Ferri et al.   ATHEROSCLEROSIS

PCSK9 in relation to coronary plaque inflammation: Results of the ATHEROREMO-IVUS study

(2016) Jin M. Cheng et al.   ATHEROSCLEROSIS

Native LDL promotes differentiation of human monocytes to macrophages with an inflammatory phenotype

(2016) Xiao-Lei Moore et al.   THROMBOSIS AND HAEMOSTASIS

NoSAS score associated with arterial stiffness in a large cohort of healthy individuals

(2016) Arrigo F G Cicero et al.   Lancet Respiratory Medicine

PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse LiverSignificance

(2015) Annie Demers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line

(2015) Massimiliano Ruscica et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation and plaque vulnerability

(2015) G. K. Hansson et al.   JOURNAL OF INTERNAL MEDICINE

Local effects of human PCSK9 on the atherosclerotic lesion

(2015) Ilaria Giunzioni et al.   JOURNAL OF PATHOLOGY

Bridging Lipid Metabolism and Innate Host Defense

(2014) C. dos Santos et al.   Science Translational Medicine

PCSK9 is a critical regulator of the innate immune response and septic shock outcome

(2014) K. R. Walley et al.   Science Translational Medicine

Profiling of Atherosclerotic Lesions by Gene and Tissue Microarrays Reveals PCSK6 as a Novel Protease in Unstable Carotid Atherosclerosis

(2013) Ljubica Perisic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

(2013) Tanja Kosenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different responses to oxidized low-density lipoproteins in human polarized macrophages

(2013) Kuniaki Hirose et al.   Lipids in Health and Disease

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

(2013) Maryssa Canuel et al.   PLoS One

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

(2012) Maxime Denis et al.   CIRCULATION

PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophages

(2012) ZHIHAN TANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels

(2011) Nicola Ferri et al.   ATHEROSCLEROSIS

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice

(2010) Elisa A. Liehn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Increased Cellular Free Cholesterol in Macrophage-specificAbca1Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

(2008) Xuewei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY