Role of dopamine in the pathophysiology of Parkinson’s disease

In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease

(2023) Marta Gonzalez-Sepulveda et al.   BRAIN

DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease

(2023) Anna Masato et al.   npj Parkinsons Disease

Prevalence of ten LRRK2 variants in Parkinson's disease: A comprehensive review

(2022) Christopher Simpson et al.   PARKINSONISM & RELATED DISORDERS

A Multi-Scale Computational Model of Levodopa-Induced Toxicity in Parkinson's Disease

(2022) Vignayanandam Ravindernath-Jayashree Muddapu et al.   Frontiers in Neuroscience

The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis

(2022) Zhi Dong Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

(2021) Jacqueline M. Tokarew et al.   ACTA NEUROPATHOLOGICA

The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, αB-Crystallin and Hsp27

(2021) Junna Hayashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo

(2021) Laura M. Vecchio et al.   JOURNAL OF NEUROCHEMISTRY

Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish

(2021) Diego Baronio et al.   Acta Physiologica

Liquid-liquid phase separation and self-assembly of a lysine derivative Fmoc-L-lysine in water-DMSO mixtures

(2021) Nikesh Narang et al.   POLYMER JOURNAL

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65

(2021) Zixuan Lin et al.   Cell Death & Disease

LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease

(2021) Youcui Wang et al.   Journal of Inflammation Research

Impairment of neuronal mitochondrial function by l-DOPA in the absence of oxygen-dependent auto-oxidation and oxidative cell damage

(2021) Philipp Hörmann et al.   Cell Death Discovery

Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster

(2021) Guiran Xiao et al.   BMC BIOLOGY

Dopamine in Parkinson's disease

(2021) Saad Latif et al.   CLINICA CHIMICA ACTA

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

(2021) Jeng-Lin Li et al.   Frontiers in Molecular Neuroscience

Alpha-Synuclein Aggregation in Parkinson's Disease

(2021) E. Srinivasan et al.   Frontiers in Medicine

Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects

(2020) Max Borsche et al.   Journal of Parkinsons Disease

The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration

(2019) Danielle E. Mor et al.   MOVEMENT DISORDERS

The Oxidative Pathway to Dopamine–Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson’s Disease

(2019) Kazumasa Wakamatsu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N‐Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

(2019) Daniel A. Monti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impaired dopamine metabolism in Parkinson’s disease pathogenesis

(2019) Anna Masato et al.   Molecular Neurodegeneration

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

(2019) Mariaelena Repici et al.   Journal of Clinical Medicine

The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson’s Disease (PD)

(2019) Zhou et al.   Cells

The modulatory role of dopamine receptors in brain neuroinflammation

(2019) Qing-Peng Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

3,4-Dihydroxyphenylacetaldehyde is more efficient than dopamine in oligomerizing and quinonizing alpha-synuclein

(2019) Yunden Jinsmaa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease

(2019) Lena F. Burbulla et al.   Science Translational Medicine

Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease

(2018) Alice Biosa et al.   ACS Chemical Neuroscience

Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages

(2018) Stefanie Dichtl et al.   BIOCHEMICAL PHARMACOLOGY

Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein

(2018) Jonathan W. Werner-Allen et al.   BIOCHEMISTRY

3,4-Dihydroxyphenylacetaldehyde-Induced Protein Modifications and Their Mitigation byN-Acetylcysteine

(2018) Yunden Jinsmaa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease

(2018) Maria Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration

(2018) Shun Zhang et al.   ACS Chemical Neuroscience

Dopamine, oxidative stress and protein-quinone modifications in Parkinson's and other neurodegenerative diseases

(2018) Enrico Monzani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into the structural biology of Gaucher disease

(2017) Laura Smith et al.   EXPERIMENTAL NEUROLOGY

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

Neuromelanin in Parkinson’s Disease: from Fenton Reaction to Calcium Signaling

(2017) Rainer Knörle   NEUROTOXICITY RESEARCH

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

(2017) N. Plotegher et al.   Scientific Reports

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

(2017) Atul Kumar et al.   eLife

Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin

(2016) Nicoletta Plotegher et al.   AGEING RESEARCH REVIEWS

Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein

(2016) Jon W. Werner-Allen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite

(2016) David G. Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activation of  -Glucocerebrosidase Reduces Pathological  -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

(2016) J. R. Mazzulli et al.   JOURNAL OF NEUROSCIENCE

Direct intranigral injection of dopaminochrome causes degeneration of dopamine neurons

(2016) Jillienne C. Touchette et al.   NEUROSCIENCE LETTERS

Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease

(2016) Lu Gao et al.   PLoS One

Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity

(2015) Kelly M. Lohr et al.   ACS Chemical Neuroscience

In vivo protein targets for increased quinoprotein adduct formation in aged substantia nigra

(2015) Guohua Yu et al.   EXPERIMENTAL NEUROLOGY

Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)

(2015) Cristian Follmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies

(2015) Davide Chiasserini et al.   Molecular Neurodegeneration

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

(2015) S.T. Masoud et al.   NEUROBIOLOGY OF DISEASE

Structural Basis for the Site-Specific Incorporation of Lysine Derivatives into Proteins

(2014) Veronika Flügel et al.   PLoS One

Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

(2013) Michelle S. Beavan et al.   ANNALS OF MEDICINE

Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

(2013) David N. Hauser et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons

(2013) Zhi Dong Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

The GTPase function of LRRK2

(2012) Jean-Marc Taymans   BIOCHEMICAL SOCIETY TRANSACTIONS

Protective Effects of L-Dopa and Carbidopa Combined Treatments on Human Catecholaminergic Cells

(2012) Monica Colamartino et al.   DNA AND CELL BIOLOGY

Dopamine-derived Quinones Affect the Structure of the Redox Sensor DJ-1 through Modifications at Cys-106 and Cys-53

(2012) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis

(2012) Emanuele Ferrari et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson’s disease

(2012) I. Lonskaya et al.   NEUROSCIENCE

Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease

(2012) Margaret Chia-Ying Wey et al.   PLoS One

Human SOD2 Modification by Dopamine Quinones Affects Enzymatic Activity by Promoting Its Aggregation: Possible Implications for Parkinson’s Disease

(2012) Elisa Belluzzi et al.   PLoS One

Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease

(2012) A. G. Fitzmaurice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease

(2011) Sirsendu Jana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update

(2011) A. Napolitano et al.   CURRENT MEDICINAL CHEMISTRY

l-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro

(2011) Sandra W. Chan et al.   EXPERIMENTAL NEUROLOGY

Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and anortho-Quinone

(2011) David G. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells

(2011) Jie Li et al.   JOURNAL OF NEURAL TRANSMISSION

Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade

(2011) W Michael Zawada et al.   Journal of Neuroinflammation

MPP+-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress

(2011) Ya-Ching Hsieh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Quinoprotein Adducts Accumulate in the Substantia Nigra of Aged Rats and Correlate with Dopamine-Induced Toxicity in SH-SY5Y Cells

(2011) Na Wang et al.   NEUROCHEMICAL RESEARCH

Inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite

(2011) Lydia M. Mexas et al.   NEUROTOXICOLOGY

Dopamine quinones interact with α-synuclein to form unstructured adducts

(2010) Marco Bisaglia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells

(2010) Marco Bisaglia et al.   BMC NEUROSCIENCE

Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration

(2010) Zhi Dong Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

(2010) A. Rakovic et al.   HUMAN MOLECULAR GENETICS

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

(2010) Yanqi Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease

(2010) Florian Bayersdorfer et al.   NEUROBIOLOGY OF DISEASE

Glutathione Conjugates with Dopamine-Derived Quinones to Form Reactive or Non-Reactive Glutathione-Conjugates

(2010) Zhi Dong Zhou et al.   NEUROCHEMICAL RESEARCH

Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

(2010) Irmgard Paris et al.   NEUROTOXICITY RESEARCH

The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis

(2010) W. Michael Panneton et al.   PLoS One

Protein Reactivity of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite, Is Dependent on Both the Aldehyde and the Catechol

(2009) Jennifer N. Rees et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mitochondrial dynamics in Parkinson's disease

(2009) Victor S. Van Laar et al.   EXPERIMENTAL NEUROLOGY

Glutathione—a review on its role and significance in Parkinson’s disease

(2009) Heather L. Martin et al.   FASEB JOURNAL

Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones

(2009) Zhi Dong Zhou et al.   FREE RADICAL RESEARCH

The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease

(2009) Teresa G. Hastings   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

(2009) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: Protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-nonenal, or hydrogen peroxide

(2008) Zhenquan Jia et al.   BRAIN RESEARCH

Myoglobin Modification by Enzyme-Generated Dopamine Reactive Species

(2008) Stefania Nicolis et al.   CHEMISTRY-A EUROPEAN JOURNAL

3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity

(2008) Lucyna Antkiewicz-Michaluk et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative and nitrative protein modifications in Parkinson's disease

(2008) Steven R. Danielson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132

(2008) Zhidong Zhou et al.   FREE RADICAL RESEARCH

DJ-1 protects against dopamine toxicity

(2008) Nirit Lev et al.   JOURNAL OF NEURAL TRANSMISSION

Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis

(2008) Thomas S. Guillot et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

(2008) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Microglial responses to dopamine in a cell culture model of Parkinson's disease

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Roles of Glutathione (GSH) in Dopamine (DA) Oxidation Studied by Improved Tandem HPLC Plus ESI-MS

(2008) Zhi Dong Zhou et al.   NEUROCHEMICAL RESEARCH

Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity

(2008) Ikuko Miyazaki et al.   NEUROCHEMICAL RESEARCH