The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration
Authors
Keywords
-
Journal
MOVEMENT DISORDERS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-01-12
DOI
10.1002/mds.27607
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
- (2018) Marthe H. R. Ludtmann et al. Nature Communications
- Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons
- (2018) Yu Ree Choi et al. Cell Reports
- Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders
- (2018) Scott Ugras et al. EBioMedicine
- α-Synuclein promotes dilation of the exocytotic fusion pore
- (2017) Todd Logan et al. NATURE NEUROSCIENCE
- Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
- (2017) Danielle E Mor et al. NATURE NEUROSCIENCE
- Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
- (2017) Fabio A. Zucca et al. PROGRESS IN NEUROBIOLOGY
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Propagation of pathological α-synuclein in marmoset brain
- (2017) Aki Shimozawa et al. Acta Neuropathologica Communications
- Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence
- (2016) Joseph R. Mazzulli et al. ANALYTICAL CHEMISTRY
- Ca2+is a key factor in α-synuclein-induced neurotoxicity
- (2016) Plamena R. Angelova et al. JOURNAL OF CELL SCIENCE
- Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
- (2016) Dena G. Hernandez et al. JOURNAL OF NEUROCHEMISTRY
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Direct intranigral injection of dopaminochrome causes degeneration of dopamine neurons
- (2016) Jillienne C. Touchette et al. NEUROSCIENCE LETTERS
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity
- (2015) Kelly M. Lohr et al. ACS Chemical Neuroscience
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits
- (2015) S.T. Masoud et al. NEUROBIOLOGY OF DISEASE
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- The Newly Discovered Parkinson’s Disease Associated Finnish Mutation (A53E) Attenuates α-Synuclein Aggregation and Membrane Binding
- (2014) Dhiman Ghosh et al. BIOCHEMISTRY
- α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling
- (2014) Lina Wang et al. CURRENT BIOLOGY
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
- (2014) Eric S. Luth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evidence of Native α-Synuclein Conformers in the Human Brain
- (2014) Neal Gould et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity
- (2014) Ossama Khalaf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protective and toxic roles of dopamine in Parkinson's disease
- (2014) Juan Segura-Aguilar et al. JOURNAL OF NEUROCHEMISTRY
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial
- (2014) PD MED Collaborative Group LANCET
- Levodopa: Effect on cell death and the natural history of Parkinson's disease
- (2014) C. Warren Olanow MOVEMENT DISORDERS
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
- (2014) Jing L Guo et al. NATURE MEDICINE
- A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
- (2014) Petra Pasanen et al. NEUROBIOLOGY OF AGING
- Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo
- (2014) Kelly M. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
- (2014) Jacqueline Burré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intramuscular injection of -synuclein induces CNS -synuclein pathology and a rapid-onset motor phenotype in transgenic mice
- (2014) A. N. Sacino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay
- (2013) Iryna Prots et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes
- (2013) Igor Dikiy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
- (2013) David S. Goldstein et al. JOURNAL OF NEUROCHEMISTRY
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
- (2013) S. Janezic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1
- (2012) Andres Binolfi et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease
- (2012) Min Jeong Park et al. Journal of Clinical Neurology
- Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1
- (2012) X. Lin et al. JOURNAL OF NEUROSCIENCE
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons
- (2012) Ayse Ulusoy et al. NEUROBIOLOGY OF DISEASE
- Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
- (2012) J. M. Milber et al. NEUROLOGY
- N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein
- (2012) Adam J. Trexler et al. PROTEIN SCIENCE
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment
- (2011) Kristel L. Emmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Does levodopa accelerate the pathologic process in Parkinson disease brain?
- (2011) L. Parkkinen et al. NEUROLOGY
- A soluble -synuclein construct forms a dynamic tetramer
- (2011) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical progression in Parkinson disease and the neurobiology of axons
- (2010) Hsiao-Chun Cheng et al. ANNALS OF NEUROLOGY
- Dopamine quinones interact with α-synuclein to form unstructured adducts
- (2010) Marco Bisaglia et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Distinct Region-Specific -Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration
- (2010) E. Tsika et al. JOURNAL OF NEUROSCIENCE
- A Pathologic Cascade Leading to Synaptic Dysfunction in -Synuclein-Induced Neurodegeneration
- (2010) D. A. Scott et al. JOURNAL OF NEUROSCIENCE
- Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
- (2010) Pengxiu Cao et al. PLoS One
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Dopamine facilitates α-synuclein oligomerization in human neuroblastoma SH-SY5Y cells
- (2009) Kentaro Yamakawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
- (2009) Damla Pinar Karpinar et al. EMBO JOURNAL
- Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner
- (2009) Chi L.L. Pham et al. JOURNAL OF MOLECULAR BIOLOGY
- Lewy Body Pathology in Normal Elderly Subjects
- (2009) William R. Markesbery et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons
- (2009) Eugene V. Mosharov et al. NEURON
- Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis
- (2008) Thomas S. Guillot et al. JOURNAL OF NEUROCHEMISTRY
- Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice
- (2008) L. Chen et al. JOURNAL OF NEUROSCIENCE
- Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease
- (2008) S. Nuber et al. JOURNAL OF NEUROSCIENCE
- Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region
- (2008) Fernando E. Herrera et al. PLoS One
- Altered vesicular dopamine storage in Parkinson's disease: a premature demise
- (2008) W. Michael Caudle et al. TRENDS IN NEUROSCIENCES
- Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and α-synuclein-deleted mice
- (2007) Daniel Alvarez-Fischer et al. EXPERIMENTAL NEUROLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started