Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

Characterization of recessive Parkinson's disease in a large multicenter study

(2020) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

(2020) Justyna Okarmus et al.   Scientific Reports

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

(2019) Tessa Dhaeze et al.   Cellular & Molecular Immunology

The Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s Disease

(2019) Wei Yi et al.   HUMAN MOLECULAR GENETICS

Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

(2019) Bojan Shutinoski et al.   Science Translational Medicine

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

(2019) Katalin Solti et al.   NEUROBIOLOGY OF DISEASE

Regulatory mechanisms of thiol-based redox sensors: lessons learned from structural studies on prokaryotic redox sensors

(2018) Sang Jae Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Chemical methods for mapping cysteine oxidation

(2018) Lisa J. Alcock et al.   CHEMICAL SOCIETY REVIEWS

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

(2018) François Mouton-Liger et al.   GLIA

Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons

(2018) Nicolas Giguère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin , PINK1 , DJ1: MDSGene Systematic Review

(2018) Meike Kasten et al.   MOVEMENT DISORDERS

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

(2018) András Micsonai et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

(2018) Xianjun Dong et al.   NATURE NEUROSCIENCE

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson’s Disease

(2016) Emanuele Ferrari et al.   ACS Chemical Neuroscience

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

The biological inorganic chemistry of zinc ions

(2016) Artur Krężel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation

(2016) Jacob D. Aguirre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

(2015) A. Kumar et al.   EMBO JOURNAL

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

(2015) András Micsonai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population

(2014) Ya-qin Wang et al.   NEUROSCIENCE LETTERS

Tissue- and Cell-Specific Mitochondrial Defect in Parkin-Deficient Mice

(2014) Maria Damiano et al.   PLoS One

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

(2013) Anne Kathrin Müller-Rischart et al.   MOLECULAR CELL

Parkin Plays a Role in Sporadic Parkinson's Disease

(2013) Ted M. Dawson et al.   Neurodegenerative Diseases

Neuromelanin of the Human Substantia Nigra: An Update

(2013) Fabio A. Zucca et al.   NEUROTOXICITY RESEARCH

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

(2013) Donald E. Spratt et al.   Nature Communications

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

S-nitrosylation regulates mitochondrial quality control via activation of parkin

(2013) Kentaro Ozawa et al.   Scientific Reports

Parkin Disease

(2013) Karen M. Doherty et al.   JAMA Neurology

About the structural role of disulfide bridges in serum albumins: Evidence from protein simulated unfolding

(2012) Guillaume Paris et al.   BIOPOLYMERS

Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease

(2012) Tohru Kitada et al.   Current Treatment Options in Neurology

Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis

(2012) Emanuele Ferrari et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase

(2012) Yi Sun et al.   Protein & Cell

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

(2011) Fanjun Meng et al.   Molecular Neurodegeneration

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression

(2010) Tamar Unger et al.   JOURNAL OF STRUCTURAL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

(2009) A. K. Berger et al.   HUMAN MOLECULAR GENETICS

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

(2009) Ventzislava A. Hristova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired dopamine release and synaptic plasticity in the striatum ofParkin−/− mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Parkinson disease(s): Is "Parkin disease" a distinct clinical entity?

(2008) C. Klein et al.   NEUROLOGY