The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis
Authors
Keywords
-
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 79, Issue 12, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-11-21
DOI
10.1007/s00018-022-04574-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
- (2021) Jacqueline M. Tokarew et al. ACTA NEUROPATHOLOGICA
- The role of gut dysbiosis in Parkinson's disease: mechanistic insights andtherapeutic options
- (2021) Qing Wang et al. BRAIN
- Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo
- (2021) Laura M. Vecchio et al. JOURNAL OF NEUROCHEMISTRY
- Imaging of the dopamine system with focus on pharmacological MRI and neuromelanin imaging
- (2021) Liesbeth Reneman et al. EUROPEAN JOURNAL OF RADIOLOGY
- LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease
- (2021) Youcui Wang et al. Journal of Inflammation Research
- Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment
- (2021) Rongfang Que et al. Frontiers in Immunology
- Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity
- (2020) Wanlin Yang et al. Frontiers in Aging Neuroscience
- Parkinson disease and the immune system — associations, mechanisms and therapeutics
- (2020) Eng-King Tan et al. Nature Reviews Neurology
- Genetics of Parkinson's disease: An introspection of its journey towards precision medicine
- (2020) Sara Bandres-Ciga et al. NEUROBIOLOGY OF DISEASE
- Parkinson’s disease: etiopathogenesis and treatment
- (2020) Joseph Jankovic et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson’s disease
- (2020) Xiaoya Gao et al. BRIEFINGS IN BIOINFORMATICS
- Genetic-environmental factors finally assessed together in Parkinson’s disease
- (2020) Jordi Clarimón JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease
- (2019) Fiona Bonello et al. HUMAN MOLECULAR GENETICS
- Impaired dopamine metabolism in Parkinson’s disease pathogenesis
- (2019) Anna Masato et al. Molecular Neurodegeneration
- The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson’s Disease (PD)
- (2019) Zhou et al. Cells
- Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease
- (2018) Alice Biosa et al. ACS Chemical Neuroscience
- 3,4-Dihydroxyphenylacetaldehyde-Induced Protein Modifications and Their Mitigation byN-Acetylcysteine
- (2018) Yunden Jinsmaa et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice
- (2018) Yulan Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease
- (2017) Zhong-Can Chen et al. Science Signaling
- Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease
- (2017) Zhong-Can Chen et al. Science Signaling
- Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice
- (2016) Michael F. Salvatore et al. ACS Chemical Neuroscience
- Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin
- (2016) Nicoletta Plotegher et al. AGEING RESEARCH REVIEWS
- Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
- (2016) Junghyun Jo et al. Cell Stem Cell
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1
- (2015) Y.-C. Lai et al. EMBO JOURNAL
- F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy
- (2015) Zhi Dong Zhou et al. HUMAN MOLECULAR GENETICS
- Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
- (2015) M. Yue et al. NEUROBIOLOGY OF DISEASE
- Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
- (2015) Dong Hwan Ho et al. Molecular Brain
- PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death
- (2014) Hyo-Kyoung Choi et al. HUMAN MOLECULAR GENETICS
- Regulation of tyrosine hydroxylase transcription by hnRNP K and DNA secondary structure
- (2014) Kasturi Banerjee et al. Nature Communications
- Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons
- (2013) Zhi Dong Zhou et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells
- (2013) Tae Eun Kim et al. PLoS One
- The GTPase function of LRRK2
- (2012) Jean-Marc Taymans BIOCHEMICAL SOCIETY TRANSACTIONS
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Epigenetic, transcriptional and posttranscriptional regulation of the tyrosine hydroxylase gene
- (2011) Robert Lenartowski et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Multiple coregulatory control of tyrosine hydroxylase gene transcription
- (2011) S. D. N. Reddy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitophagy and Parkinson's disease: The PINK1–parkin link
- (2010) Emma Deas et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration
- (2010) Zhi Dong Zhou et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
- (2010) Seok Min Jin et al. JOURNAL OF CELL BIOLOGY
- Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
- (2010) X. Li et al. JOURNAL OF NEUROSCIENCE
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease
- (2010) Florian Bayersdorfer et al. NEUROBIOLOGY OF DISEASE
- The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis
- (2010) W. Michael Panneton et al. PLoS One
- Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study
- (2009) Eiichi Akahoshi et al. Environmental Health
- Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones
- (2009) Zhi Dong Zhou et al. FREE RADICAL RESEARCH
- Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
- (2009) C.-H. Ng et al. JOURNAL OF NEUROSCIENCE
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132
- (2008) Zhidong Zhou et al. FREE RADICAL RESEARCH
- Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
- (2008) Ryan D. Mills et al. JOURNAL OF NEUROCHEMISTRY
- Dopamine auto-oxidation aggravates non-apoptotic cell death induced by over-expression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells
- (2008) Zhi Dong Zhou et al. JOURNAL OF NEUROCHEMISTRY
- Roles of Glutathione (GSH) in Dopamine (DA) Oxidation Studied by Improved Tandem HPLC Plus ESI-MS
- (2008) Zhi Dong Zhou et al. NEUROCHEMICAL RESEARCH
- PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
- (2008) Alison Wood-Kaczmar et al. PLoS One
- Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ
- (2003) Michael F. Salvatore et al. JOURNAL OF NEUROCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now