The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, αB-Crystallin and Hsp27

The multifaceted nature of αB-crystallin

(2020) Junna Hayashi et al.   CELL STRESS & CHAPERONES

Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

(2020) Urmi Sengupta et al.   MOLECULAR NEUROBIOLOGY

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

(2019) Iria Carballo-Carbajal et al.   Nature Communications

Local unfolding of the HSP27 monomer regulates chaperone activity

(2019) T. Reid Alderson et al.   Nature Communications

Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins

(2018) John A. Carver et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures

(2018) Fillipe M. de Araújo et al.   NEUROTOXICOLOGY

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease

(2018) Michael Jewett et al.   Frontiers in Neurology

Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic

(2018) Sandro Huenchuguala et al.   NEUROTOXICITY RESEARCH

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation

(2016) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein

(2016) Pegah Kord Forooshani et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Direct intranigral injection of dopaminochrome causes degeneration of dopamine neurons

(2016) Jillienne C. Touchette et al.   NEUROSCIENCE LETTERS

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection

(2016) Sarah Plum et al.   Scientific Reports

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease

(2015) Yingjun Liu et al.   NEUROBIOLOGY OF AGING

Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin

(2015) Andrea Briceño et al.   NEUROTOXICITY RESEARCH

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

(2015) András Micsonai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preventing α-synuclein aggregation: The role of the small heat-shock molecular chaperone proteins

(2014) Dezerae Cox et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Small heat-shock proteins: important players in regulating cellular proteostasis

(2014) Teresa M. Treweek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Jack of all trades: versatile catechol crosslinking mechanisms

(2014) Juan Yang et al.   CHEMICAL SOCIETY REVIEWS

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

(2014) Carlos Cuevas et al.   NEUROTOXICITY RESEARCH

The structured core domain of  B-crystallin can prevent amyloid fibrillation and associated toxicity

(2014) G. K. A. Hochberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

(2013) David N. Hauser et al.   FREE RADICAL BIOLOGY AND MEDICINE

The small heat-shock protein αB-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of α-lactalbumin

(2012) Melissa Kulig et al.   BIOCHEMICAL JOURNAL

Dopamine Oxidation and Autophagy

(2012) Patricia Muñoz et al.   Parkinsons Disease

Enhanced molecular chaperone activity of the small heat-shock protein αB-crystallin following covalent immobilization onto a solid-phase support

(2011) Megan Garvey et al.   BIOPOLYMERS

N-terminal domain of  B-crystallin provides a conformational switch for multimerization and structural heterogeneity

(2011) S. Jehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Dopamine quinones interact with α-synuclein to form unstructured adducts

(2010) Marco Bisaglia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The structure of dopamine induced α-synuclein oligomers

(2010) Agata Rekas et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, αA- and αB-crystallin

(2010) Teresa M. Treweek et al.   EXPERIMENTAL EYE RESEARCH

Large-scale screening of the Gaucher's disease-related glucocerebrosidase gene in Europeans with Parkinson's disease

(2010) Suzanne Lesage et al.   HUMAN MOLECULAR GENETICS

The role of the cysteine residue in the chaperone and anti-apoptotic functions of human Hsp27

(2010) NagaRekha Pasupuleti et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

(2010) Irmgard Paris et al.   NEUROTOXICITY RESEARCH

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds

(2009) Sean A. Hudson et al.   FEBS Journal

Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation

(2009) Su Ling Leong et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Biochemical and Functional Protein Complex Involving Dopamine Synthesis and Transport into Synaptic Vesicles

(2009) Etienne A. Cartier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner

(2009) Chi L.L. Pham et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

(2009) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

(2008) Fernando E. Herrera et al.   PLoS One