Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment

Disease tolerance: a protective mechanism of lung infections

(2023) Jianqiao Xu et al.   Frontiers in Cellular and Infection Microbiology

Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis

(2023) Zheng Gong et al.   Science Immunology

A pan-cancer single-cell panorama of human natural killer cells

(2023) Fei Tang et al.   CELL

Surfactant lipids inhibit PI3K-dependent signaling pathways induced by IL-4 in alveolar macrophages

(2023) Cristina Casals et al.   JOURNAL OF IMMUNOLOGY

Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?

(2023) Florian Lepretre et al.   European Respiratory Review

Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

(2022) Zheng Gong et al.   IMMUNITY

Recruited and Tissue-Resident Natural Killer Cells in the Lung During Infection and Cancer

(2022) Miriam Franklin et al.   Frontiers in Immunology

Tissue‐resident CD69 + CXCR6 + Natural Killer cells with exhausted phenotype accumulate in human non‐small cell lung cancer

(2022) Xiaoke Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor

(2021) Hyunho Yoon et al.   Oncogenesis

Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges

(2021) José Carlos Castillo-Sánchez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy

(2021) Cristina Zalfa et al.   Frontiers in Immunology

Downregulation of NKG2DLs by TGF-β in human lung cancer cells

(2021) Young Shin Lee et al.   BMC IMMUNOLOGY

Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections

(2021) Duncan C. Humphries et al.   Frontiers in Immunology

TGF-β in radiotherapy: mechanisms of tumor resistance and normal tissues injury

(2020) Bagher Farhood et al.   PHARMACOLOGICAL RESEARCH

Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)

(2020) Christina W. Agudelo et al.   PLoS One

SnapShot: Natural Killer Cells

(2020) Adeline Crinier et al.   CELL

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

(2020) Jing Ni et al.   IMMUNITY

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Genetic causes of surfactant protein abnormalities

(2019) Lawrence M. Nogee   CURRENT OPINION IN PEDIATRICS

Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives

(2019) Braeden Medeiros et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

NK Cells in the Human Lungs

(2019) Baptiste Hervier et al.   Frontiers in Immunology

Natural Killer Cells in the Lungs

(2019) Jingjing Cong et al.   Frontiers in Immunology

NK Cell Dysfunction and Checkpoint Immunotherapy

(2019) Jiacheng Bi et al.   Frontiers in Immunology

NK Cell Metabolism and Tumor Microenvironment

(2019) Iñigo Terrén et al.   Frontiers in Immunology

The Acidic Tumor Microenvironment as a Driver of Cancer

(2019) Ebbe Boedtkjer et al.   Annual Review of Physiology

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression

(2018) Jingjing Cong et al.   Cell Metabolism

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

TGF-β Signaling in Lung Health and Disease

(2018) Akira Saito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

(2018) Helena M. Izquierdo et al.   Cell Reports

Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation

(2018) Arum Park et al.   Frontiers in Immunology

Transforming growth factor‐β signaling: Tumorigenesis and targeting for cancer therapy

(2018) Amirhossein Ahmadi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation

(2018) Wen Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages

(2018) Meili Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues

(2018) Roberta Castriconi et al.   Frontiers in Immunology

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69 − CD56 dim cells

(2017) Nicole Marquardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Natural killer cell-mediated immunosurveillance of human cancer

(2017) Karl-Johan Malmberg et al.   SEMINARS IN IMMUNOLOGY

NK Cell Exhaustion

(2017) Jiacheng Bi et al.   Frontiers in Immunology

Oxygen Levels and Immunological Studies

(2017) Lauren A. Zenewicz   Frontiers in Immunology

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine

(2017) Peter Vaupel et al.   Frontiers in Immunology

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Surfactant protein A: A key player in lung homeostasis

(2016) Nadia Nathan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Surfactant Protein A Prevents IFN-γ/IFN-γ Receptor Interaction and Attenuates Classical Activation of Human Alveolar Macrophages

(2016) Carlos M. Minutti et al.   JOURNAL OF IMMUNOLOGY

Increased airway glucose increases airway bacterial load in hyperglycaemia

(2016) Simren K. Gill et al.   Scientific Reports

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice

(2015) Mathieu C. Morissette et al.   EUROPEAN RESPIRATORY JOURNAL

Glucose, glycolysis and lymphocyte responses

(2015) Raymond P. Donnelly et al.   MOLECULAR IMMUNOLOGY

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Alveolar Epithelial Type II Cells Induce T Cell Tolerance to Specific Antigen

(2014) B. Lo et al.   JOURNAL OF IMMUNOLOGY

Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling

(2014) Y Hasegawa et al.   ONCOGENE

NK Cell Phenotypic Modulation in Lung Cancer Environment

(2014) Shi Jin et al.   PLoS One

TGF- -inducible microRNA-183 silences tumor-associated natural killer cells

(2014) S. S. Donatelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surfactant Protein A Suppresses Lung Cancer Progression by Regulating the Polarization of Tumor-Associated Macrophages

(2013) Atsushi Mitsuhashi et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

(2013) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Low-Glucose Conditions of Tumor Microenvironment Enhance Cytotoxicity of Tetrathiomolybdate to Neuroblastoma Cells

(2013) Jarmila Navrátilová et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity

(2012) G. Pietra et al.   CANCER RESEARCH

Lung natural killer cells in mice: phenotype and response to respiratory infection

(2012) Jian Wang et al.   IMMUNOLOGY

Mouse Lung and Spleen Natural Killer Cells Have Phenotypic and Functional Differences, in Part Influenced by Macrophages

(2012) Tatiana Michel et al.   PLoS One

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Mapping of NKp46+ Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues

(2012) Elena Tomasello et al.   Frontiers in Immunology

Tumor microenvironment in NSCLC suppresses NK cells function

(2012) Isabelle Cremer et al.   OncoImmunology

Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

(2011) Dawn Holt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

(2011) S. Platonova et al.   CANCER RESEARCH

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice

(2011) Kazuyoshi Takeda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Natural Killer Cells Are Involved in Acute Lung Immune Injury Caused by Respiratory Syncytial Virus Infection

(2011) F. Li et al.   JOURNAL OF VIROLOGY

Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways

(2011) Alejandro A. Pezzulo et al.   PLoS One

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Tumor-Infiltrating Foxp3+ Regulatory T Cells are Correlated with Cyclooxygenase-2 Expression and are Associated with Recurrence in Resected Non-small Cell Lung Cancer

(2010) Katsuhiko Shimizu et al.   Journal of Thoracic Oncology

Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4- Arrestin1-c-Src Signalsome

(2010) J. I. Kim et al.   MOLECULAR CANCER RESEARCH

Natural killer cells in infection and inflammation of the lung

(2009) Fiona J. Culley   IMMUNOLOGY

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

(2009) M. Balsamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56brightCD16− cells and display an impaired capability to kill tumor cells

(2008) Paolo Carrega et al.   CANCER

Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression

(2008) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY