Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives

Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding

(2018) Hehai Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Breast cancer lung metastasis: Molecular biology and therapeutic implications

(2018) Liting Jin et al.   CANCER BIOLOGY & THERAPY

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

(2018) Pernilla Roswall et al.   NATURE MEDICINE

Exosome isolation from distinct biofluids using precipitation and column-based approaches

(2018) Tânia Soares Martins et al.   PLoS One

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

Exosome-mediated breast cancer chemoresistance via miR-155 transfer

(2018) Juliana Carvalho Santos et al.   Scientific Reports

Risk factors and survival outcomes in patients with breast cancer and lung metastasis: a population-based study

(2018) Weikai Xiao et al.   Cancer Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Abstract 3929: The FAD-directed LSD1 specific inhibitor, INCB059872, inhibits cell migration and metastasis by suppressing premetastatic niche formation in a spontaneous metastasis mouse model

(2018) Sang Hyun Lee et al.   CANCER RESEARCH

Abstract 101: Human bone marrow-derived endothelial progenitor cells promote the transformation of periostin-positive hepatocellular carcinoma cells into CD36-positive metastasis-initialing cells in pre-metastatic niche

(2018) Xiaozai Xie et al.   CANCER RESEARCH

Role of hypoxia-induced exosomes in tumor biology

(2018) Chuchu Shao et al.   Molecular Cancer

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe

(2018) Ling-Yan Zhai et al.   ACS Applied Materials & Interfaces

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

(2018) Yael Raz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

(2018) Ioanna Keklikoglou et al.   NATURE CELL BIOLOGY

The clinical promise of immunotherapy in triple-negative breast cancer

(2018) Praveen Vikas et al.   Cancer Management and Research

Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling

(2018) Siyang Wen et al.   CANCER LETTERS

Detecting Blood-Based Biomarkers in Metastatic Breast Cancer: A Systematic Review of Their Current Status and Clinical Utility

(2017) A. Berghuis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physiological roles of macrophages

(2017) Siamon Gordon et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation

(2017) Zeqian Yu et al.   Oncotarget

Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study

(2017) Qi Wu et al.   Oncotarget

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer

(2017) Elvira Donnarumma et al.   Oncotarget

Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment

(2017) Michel Eisenblaetter et al.   Theranostics

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

(2016) Jina Ko et al.   ANALYST

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

(2016) Sarah A. Bliss et al.   CANCER RESEARCH

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanomechanical sandwich assay for multiple cancer biomarkers in breast cancer cell-derived exosomes

(2016) H. Etayash et al.   Nanoscale

Cancer-associated fibroblasts: A multifaceted driver of breast cancer progression

(2015) Haojun Luo et al.   CANCER LETTERS

Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production

(2015) S. C. Chafe et al.   CANCER RESEARCH

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

(2015) Amber Jin Giles et al.   CANCER RESEARCH

Immunosuppression associated with chronic inflammation in the tumor microenvironment

(2015) Dingzhi Wang et al.   CARCINOGENESIS

Immunosuppressive cells in tumor immune escape and metastasis

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases

(2015) Andreia L Bates et al.   JOURNAL OF PATHOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF

(2015) Yanke Chen et al.   Oncotarget

Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche

(2015) Catherine A. Sánchez et al.   Oncotarget

The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors

(2015) Lucia D’Amico et al.   Journal of Immunology Research

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment

(2015) Young Nak Joo et al.   Oncotarget

Lung-Derived Factors Mediate Breast Cancer Cell Migration through CD44 Receptor-Ligand Interactions in a Novel Ex Vivo System for Analysis of Organ-Specific Soluble Proteins

(2015) Jenny E. Chu et al.   NEOPLASIA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts

(2014) Yanan Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth

(2014) Kshitij Srivastava et al.   CANCER CELL

Osteopontin Shapes Immunosuppression in the Metastatic Niche

(2014) Sabina Sangaletti et al.   CANCER RESEARCH

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2

(2014) SHILI LIU et al.   ONCOLOGY REPORTS

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

(2014) Amy Chow et al.   Scientific Reports

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage

(2013) Amr S. Abu Lila et al.   JOURNAL OF CONTROLLED RELEASE

The metastasis-promoting roles of tumor-associated immune cells

(2013) Heath A. Smith et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Correction: Very Late Antigen-4 (α4β1Integrin) Targeted PET Imaging of Multiple Myeloma

(2013) Deepti Soodgupta et al.   PLoS One

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

(2012) Carmen Chak-Lui Wong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Inhibition of TGF-β/Smad Signaling by BAMBI Blocks Differentiation of Human Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts and Abolishes their Protumor Effects

(2012) Lei Shangguan et al.   STEM CELLS

Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy

(2012) Shyam A. Patel et al.   Scientific Reports

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

(2011) Ryuichi Morishita   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Comparison of allergic reactions to pegasparaginase given intravenously versus intramuscularly

(2011) Mahati Pidaparti et al.   PEDIATRIC BLOOD & CANCER

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Plasma Fibronectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion

(2010) Gunjan Malik et al.   CANCER RESEARCH

CXCR4 and cancer

(2010) Bungo Furusato et al.   PATHOLOGY INTERNATIONAL

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

(2010) S. L. Stott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biological role and regulation of versican levels in cancer

(2009) Carmela Ricciardelli et al.   CANCER AND METASTASIS REVIEWS

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Circulating Tumor Cell Analysis: Technical and Statistical Considerations for Application to the Clinic

(2009) Alison L. Allan et al.   Journal of Oncology

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis

(2008) A Calvo et al.   ONCOGENE