TGF-β Signaling in Lung Health and Disease

TBX4 is involved in the super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts

(2018) Masafumi Horie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3

(2018) Christie A. Ojiaku et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Asthma

(2018) Alberto Papi et al.   LANCET

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC

(2017) Masafumi Horie et al.   MOLECULAR CANCER RESEARCH

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

Roles of signaling and transcriptional networks in pathological lymphangiogenesis

(2016) Yasuhiro Yoshimatsu et al.   ADVANCED DRUG DELIVERY REVIEWS

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

(2016) Yael Aschner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate

(2016) Aimin Li et al.   BMC BIOLOGY

YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer

(2016) Masafumi Horie et al.   CANCER SCIENCE

An updated meta-analysis of transforming growth factor-β1 gene: Three well-characterized polymorphisms with asthma

(2016) Ying-shui Yao et al.   HUMAN IMMUNOLOGY

Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition

(2016) Hongyuan Chang et al.   NUCLEIC ACIDS RESEARCH

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

(2015) M. J. Schliekelman et al.   CANCER RESEARCH

Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression

(2015) Masao Saitoh   CANCER SCIENCE

Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications

(2015) Jun Xu et al.   Cell Stem Cell

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway

(2015) Fumihiko Murai et al.   Cell Discovery

Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer

(2014) Masafumi Horie et al.   BMC CANCER

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression

(2014) Kazunobu Isogaya et al.   CELL RESEARCH

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling

(2013) Lan Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reversal of Myofibroblast Differentiation by Prostaglandin E2

(2013) Garth Garrison et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Mechanisms of Airway Remodeling

(2013) Nobuaki Hirota et al.   CHEST

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells

(2013) Akira Saito et al.   PLoS One

Latent TGF-  binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5

(2013) K. Noda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF  Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease

(2013) P. A. Frischmeyer-Guerrerio et al.   Science Translational Medicine

Characterization of human lung cancer-associated fibroblasts in three-dimensional in vitro co-culture model

(2012) Masafumi Horie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combined Pulmonary Fibrosis and Emphysema Syndrome

(2012) Matthew D. Jankowich et al.   CHEST

EMT and interstitial lung disease

(2012) Hidenori Kage et al.   CURRENT OPINION IN PULMONARY MEDICINE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide mechanisms of Smad binding

(2012) M Morikawa et al.   ONCOGENE

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer

(2010) Roy-Akira Saito et al.   CANCER RESEARCH

Signaling via Alk5 controls the ontogeny of lung Clara cells

(2010) Y. Xing et al.   DEVELOPMENT

Control of lung development by latent TGF-β binding proteins

(2010) Branka Dabovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice

(2010) Kristy A. Bauman et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis

(2010) Min Li et al.   JOURNAL OF CLINICAL INVESTIGATION

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Thyroid Transcription Factor-1 Inhibits Transforming Growth Factor- -Mediated Epithelial-to-Mesenchymal Transition in Lung Adenocarcinoma Cells

(2009) R.-A. Saito et al.   CANCER RESEARCH

Airway smooth muscle thickness in asthma is related to severity but not duration of asthma

(2009) A. L. James et al.   EUROPEAN RESPIRATORY JOURNAL

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Mechanisms of TGFβ inhibition of LUNG endodermal morphogenesis: The role of TβRII, Smads, Nkx2.1 and Pten

(2008) Yiming Xing et al.   DEVELOPMENTAL BIOLOGY

TGF-  receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung

(2008) H. Chen et al.   EUROPEAN RESPIRATORY JOURNAL

CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling

(2008) Jennifer Kearley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mesodermal Deletion of Transforming Growth Factor-β Receptor II Disrupts Lung Epithelial Morphogenesis

(2008) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β

(2008) Kana Horiguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The type I TGF-β receptor is covalently modified and regulated by sumoylation

(2008) Jong Seok Kang et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE