Disease tolerance: a protective mechanism of lung infections

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

(2022) Tania Wong Fok Lung et al.   Cell Metabolism

TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

(2021) Benjamin H. Gern et al.   Cell Host & Microbe

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

(2021) Hani Harb et al.   IMMUNITY

The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections

(2021) Franziska Hornung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state

(2020) Samira Mansouri et al.   Mucosal Immunology

Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation

(2020) Chloé Michaudel et al.   Frontiers in Immunology

Amphiregulin inhibits TNF-α-induced alveolar epithelial cell death through EGFR signaling pathway

(2020) Chen Meng et al.   BIOMEDICINE & PHARMACOTHERAPY

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

(2020) Christopher M Petrilli et al.   BMJ-British Medical Journal

Impact of Tregs on AT2 Cell Transcriptomes During Resolution of ALI and Contributions of IFN-γ

(2020) Jason R Mock et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions

(2020) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Distal lung epithelial progenitor cell function declines with age

(2020) Julie K. Watson et al.   Scientific Reports

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

(2020) Chaofu Wang et al.   EBioMedicine

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

(2020) Ahmed Sadik et al.   CELL

Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model

(2020) Yu‐Di Chang et al.   FASEB JOURNAL

Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection

(2020) Henrique G. Colaço et al.   IMMUNITY

A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma

(2020) Hani Harb et al.   NATURE IMMUNOLOGY

Low-Dose LPS Induces Tolerogenic Treg Skewing in Asthma

(2020) Fengxia Ding et al.   Frontiers in Immunology

The effects of aging on host resistance and disease tolerance to SARS‐CoV‐2 infection

(2020) Darren Z. L. Mok et al.   FEBS Journal

Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging

(2020) Megumi Inomata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases

(2019) Seung Joon Baek et al.   PHARMACOLOGY & THERAPEUTICS

Interleukin-10 produced by myeloid derived suppressor cells provides protection to Carbapenem-resistant Klebsiella pneumoniae ST258 by enhancing its clearance in the airways

(2019) Hernán F. Peñaloza et al.   INFECTION AND IMMUNITY

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

(2019) Carlos M. Minutti et al.   IMMUNITY

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

(2019) Kirthana Ganeshan et al.   CELL

Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

(2019) Lang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Leukotriene B4–type I interferon axis regulates macrophage-mediated disease tolerance to influenza infection

(2019) Erwan Pernet et al.   Nature Microbiology

Tolerogenic signalling of alveolar macrophages induces lung adaptation to oxidative injury

(2019) Benoit Allard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endotoxin‐induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst

(2019) Inge Grondman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-22-binding protein exacerbates influenza, bacterial super-infection

(2019) Robert N. Abood et al.   Mucosal Immunology

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

(2019) Amanda Ardain et al.   NATURE

Site-Specific Reprogramming of Macrophage Responsiveness to Bacterial Lipopolysaccharide in Obesity

(2019) Evilin N. Komegae et al.   Frontiers in Immunology

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

IL-22 Binding Protein Constrains IL-22 Activity, Host Defense and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia

(2019) Giraldina Trevejo-Nunez et al.   INFECTION AND IMMUNITY

Aryl hydrocarbon receptor ligands enhance lung immunity through intestinal IKKβ pathways

(2019) Tzyy-Bin Tsay et al.   Journal of Translational Medicine

miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer

(2019) Qiong Lou et al.   Journal for ImmunoTherapy of Cancer

NK cell recruitment limits tissue damage during an enteric helminth infection

(2019) Maria E. Gentile et al.   Mucosal Immunology

Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection

(2019) K. D. Hebert et al.   Mucosal Immunology

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

(2019) Tomomi Ichikawa et al.   NATURE IMMUNOLOGY

Interleukin-22 regulates interferon lambda expression in a mice model of pseudomonas aeruginosa pneumonia

(2019) Alexis Broquet et al.   MOLECULAR IMMUNOLOGY

Disease tolerance: concept and mechanisms

(2018) JL McCarville et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion

(2018) Adeline Barthelemy et al.   INFECTION AND IMMUNITY

Live Vaccination Generates Both Disease Tolerance and Host Resistance During Chronic Pulmonary Infection With Highly Virulent Francisella tularensis SchuS4

(2018) Alicia M Soucy et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreases Pseudomonas aeruginosa pneumonia

(2018) Sena Kim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

(2018) Yuefeng Huang et al.   SCIENCE

Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2prevents experimental lung neutrophilic inflammation

(2018) Jennifer M Felton et al.   THORAX

Surviving Deadly Lung Infections: Innate Host Tolerance Mechanisms in the Pulmonary System

(2018) Meredith J. Crane et al.   Frontiers in Immunology

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection

(2018) Vineel P. Reddy et al.   Frontiers in Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model

(2018) Noora Ottman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

(2018) Jonathan D. Proto et al.   IMMUNITY

Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance

(2018) Nora Branzk et al.   IMMUNOLOGICAL REVIEWS

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

(2018) Carlos del Fresno et al.   SCIENCE

Beyond Killing Mycobacterium tuberculosis: Disease Tolerance

(2018) Maziar Divangahi et al.   Frontiers in Immunology

Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility

(2018) George S. Yap et al.   Frontiers in Immunology

Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice

(2017) Christine K. Wong et al.   JOURNAL OF IMMUNOLOGY

Peptidoglycan from Immunobiotic Lactobacillus rhamnosus Improves Resistance of Infant Mice to Respiratory Syncytial Viral Infection and Secondary Pneumococcal Pneumonia

(2017) Patricia Clua et al.   Frontiers in Immunology

Disease Tolerance Mediated by Phosphorylated Indoleamine-2,3 Dioxygenase Confers Resistance to a Primary Fungal Pathogen

(2017) Eliseu Frank de Araújo et al.   Frontiers in Immunology

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis

(2016) Nasr Y. A. Hemdan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammatory signaling in human tuberculosis granulomas is spatially organized

(2016) Mohlopheni J Marakalala et al.   NATURE MEDICINE

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

(2016) Jonathan Maelfait et al.   PLoS Pathogens

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice

(2015) J. Justin Milner et al.   JOURNAL OF IMMUNOLOGY

Community-acquired pneumonia

(2015) Elena Prina et al.   LANCET

Telomere dysfunction causes alveolar stem cell failure

(2015) Jonathan K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling

(2015) A. M. P. Schieber et al.   SCIENCE

Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand

(2014) Maria Tsoumakidou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Acute Pulmonary Lipopolysaccharide Tolerance Decreases TNF-  without Reducing Neutrophil Recruitment

(2014) S. Natarajan et al.   JOURNAL OF IMMUNOLOGY

Activation of Type 3 Innate Lymphoid Cells and Interleukin 22 Secretion in the Lungs During Streptococcus pneumoniae Infection

(2014) Laurye Van Maele et al.   JOURNAL OF INFECTIOUS DISEASES

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells

(2013) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

Induction and Role of Indoleamine 2,3 Dioxygenase in Mouse Models of Influenza A Virus Infection

(2013) Lei Huang et al.   PLoS One

Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection

(2013) A. M. Jamieson et al.   SCIENCE

Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages

(2013) Jian Wang et al.   Nature Communications

Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation

(2013) Anuradha Ray et al.   Frontiers in Cellular and Infection Microbiology

Tolerance of Infections

(2012) Janelle S. Ayres et al.   Annual Review of Immunology

Neutrophil – CD4+CD25+ T regulatory cell interactions: A possible new mechanism of infectious tolerance

(2012) Natalia Lewkowicz et al.   IMMUNOBIOLOGY

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Impaired Wound Healing Predisposes Obese Mice to Severe Influenza Virus Infection

(2011) Kevin B. O’Brien et al.   JOURNAL OF INFECTIOUS DISEASES

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation

(2010) Marlene E. Starr et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology