A pan-cancer single-cell panorama of human natural killer cells

Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

(2022) Chunhong Zheng et al.   CANCER CELL

Innate lymphoid cells and cancer

(2022) Nicolas Jacquelot et al.   NATURE IMMUNOLOGY

Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

(2022) Chuang Guo et al.   Genome Medicine

CAR-NK cells for cancer immunotherapy: from bench to bedside

(2022) Leisheng Zhang et al.   Biomarker Research

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

(2022) Adrienne M. Luoma et al.   CELL

Impaired intratumoral natural killer cell function in head and neck carcinoma

(2022) Dalila Mele et al.   Frontiers in Immunology

Downregulation of CD16 Surface Expression on NK Cells Is a Favorable Prognostic Factor in Acute Myeloid Leukemia

(2022) Huaiyu Wang et al.   BLOOD

Alterations of NK Cell Phenotype in the Disease Course of Multiple Myeloma

(2021) Tatiana Pazina et al.   Cancers

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

(2021) Sijin Cheng et al.   CELL

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

(2021) Karthik Dhatchinamoorthy et al.   Frontiers in Immunology

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer

(2021) Di Huang et al.   NATURE IMMUNOLOGY

Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

(2021) Andrea Ziblat et al.   Frontiers in Immunology

Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft

(2021) Duy Tri Le et al.   JCI Insight

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

(2021) Yuanyuan Zhang et al.   CANCER CELL

Pan-cancer single-cell landscape of tumor-infiltrating T cells

(2021) Liangtao Zheng et al.   SCIENCE

Tissue Determinants of Human NK Cell Development, Function, and Residence

(2020) Pranay Dogra et al.   CELL

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation

(2020) Simon McArthur et al.   JOURNAL OF CLINICAL INVESTIGATION

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence

(2020) Sean J. Judge et al.   Frontiers in Cellular and Infection Microbiology

Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors

(2020) Ombretta Melaiu et al.   Frontiers in Immunology

Minimal PD-1 expression in mouse and human NK cells under diverse conditions

(2020) Sean J. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma

(2020) Bruno Sangro et al.   JOURNAL OF HEPATOLOGY

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

An entropy-based metric for assessing the purity of single cell populations

(2020) Baolin Liu et al.   Nature Communications

Deep learning–based cell composition analysis from tissue expression profiles

(2020) Kevin Menden et al.   Science Advances

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

(2019) Xindong Liu et al.   NATURE

Targeting natural killer cells in solid tumors

(2019) Guillaume Habif et al.   Cellular & Molecular Immunology

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Mechanisms of natural killer cell‐mediated cellular cytotoxicity

(2019) Isabel Prager et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes

(2019) Marcel Costa-García et al.   Frontiers in Immunology

BBKNN: fast batch alignment of single cell transcriptomes

(2019) Krzysztof Polański et al.   BIOINFORMATICS

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

(2019) Andrew J. Freeman et al.   Cell Reports

NK Cell Dysfunction and Checkpoint Immunotherapy

(2019) Jiacheng Bi et al.   Frontiers in Immunology

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

(2019) Chao Yang et al.   Nature Communications

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

(2019) Hyunchul Jung et al.   Nature Communications

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

(2018) Qing Zhang et al.   NATURE IMMUNOLOGY

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

Adaptive NK Cells Resist Regulatory T-cell Suppression Driven by IL37

(2018) Dhifaf Sarhan et al.   Cancer Immunology Research

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages

(2018) Hefin I. Rhys et al.   EBioMedicine

Human AML activates the AHR pathway to impair NK cell development and function

(2018) Steven D. Scoville et al.   BLOOD

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Natural Killer Cells: Development, Maturation, and Clinical Utilization

(2018) Alex M. Abel et al.   Frontiers in Immunology

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

(2018) Hanjie Li et al.   CELL

High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

(2018) Adeline Crinier et al.   IMMUNITY

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

(2017) Arjun V Balar et al.   LANCET

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Natural Killer Defective Maturation Is Associated with Adverse Clinical Outcome in Patients with Acute Myeloid Leukemia

(2017) Anne-Sophie Chretien et al.   Frontiers in Immunology

The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing

(2016) Åsa K Björklund et al.   NATURE IMMUNOLOGY

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer

(2016) Cheng Sun et al.   OncoImmunology

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

(2014) Cheng Sun et al.   Cellular & Molecular Immunology

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

(2014) Dorothy K Sojka et al.   eLife

T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis

(2013) Jiacheng Bi et al.   HEPATOLOGY

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

(2013) Hui Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells

(2012) Suling Li et al.   IMMUNITY

Role of Kruppel-like factors in leukocyte development, function, and disease

(2010) Z. Cao et al.   BLOOD

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

(2009) N. Stanietsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients

(2008) Lun Cai et al.   CLINICAL IMMUNOLOGY

Correlation between NK function and response to trastuzumab in metastatic breast cancer patients

(2008) Alessandra Beano et al.   Journal of Translational Medicine