Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections

Activated neutrophil fluorescent imaging technique for human lungs

(2021) Thomas H. Craven et al.   Scientific Reports

Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage

(2021) Violaine Dubois et al.   npj Vaccines

T resident helper cells promote humoral responses in the lung

(2021) Nivedya Swarnalekha et al.   Science Immunology

Tissues, not blood, are where immune cells function

(2021) Donna L. Farber   NATURE

Local heroes or villains: tissue-resident memory T cells in human health and disease

(2020) S. C. Sasson et al.   Cellular & Molecular Immunology

Prevention of tuberculosis in macaques after intravenous BCG immunization

(2020) Patricia A. Darrah et al.   NATURE

Resident Memory B Cells

(2020) S. Rameeza Allie et al.   VIRAL IMMUNOLOGY

Cutting Edge: Characterization of Human Tissue-Resident Memory T Cells at Different Infection Sites in Patients with Tuberculosis

(2020) Qianting Yang et al.   JOURNAL OF IMMUNOLOGY

TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection

(2020) Emma C. Reilly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection

(2020) J. Michael Stolley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Covid-19: Perspectives on Innate Immune Evasion

(2020) Nima Taefehshokr et al.   Frontiers in Immunology

Human Lung Resident Macrophages Co-localize with and Provide Co-stimulation to PD1hi Tissue Resident Memory T Cells

(2020) Mark E. Snyder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections

(2020) Jonah Clegg et al.   TRENDS IN IMMUNOLOGY

Memory T Cell Dynamics in the Lung during Influenza Virus Infection

(2019) Angela Pizzolla et al.   JOURNAL OF IMMUNOLOGY

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

(2019) Karin Dijkman et al.   NATURE MEDICINE

HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis

(2019) Björn Corleis et al.   Cell Reports

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

(2019) Marios Koutsakos et al.   NATURE IMMUNOLOGY

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location

(2019) Daniel A. Walsh et al.   JOURNAL OF IMMUNOLOGY

Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release

(2019) Elizabeth A. Thompson et al.   Cell Reports

Editorial: Tissue Resident Memory T Cells

(2019) Fathia Mami-Chouaib et al.   Frontiers in Immunology

Lung Tissue Resident Memory T-Cells in the Immune Response to Mycobacterium tuberculosis

(2019) Paul Ogongo et al.   Frontiers in Immunology

Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination

(2019) Anna-Karin E. Palm et al.   Frontiers in Immunology

Site-Specific DC Surface Signatures Influence CD4+ T Cell Co-stimulation and Lung-Homing

(2019) David Pejoski et al.   Frontiers in Immunology

Human lung tissue resident memory T cells in health and disease

(2019) Mark E Snyder et al.   CURRENT OPINION IN IMMUNOLOGY

Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung

(2019) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

(2019) Vinidhra Mani et al.   SCIENCE

Tissue-Resident Macrophages Limit Pulmonary CD8 Resident Memory T Cell Establishment

(2019) Nick P. Goplen et al.   Frontiers in Immunology

Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection

(2019) Aleks Guvenel et al.   JOURNAL OF CLINICAL INVESTIGATION

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

(2019) Chenghao Ge et al.   Cell Reports

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination

(2018) Joshua I. Gray et al.   IMMUNOLOGY

Low-cost high sensitivity pulsed endomicroscopy to visualize tricolor optical signatures

(2018) Nikola Krstajić et al.   JOURNAL OF BIOMEDICAL OPTICS

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

(2018) Angela Pizzolla et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma

(2018) Sean R. McMaster et al.   Mucosal Immunology

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

(2018) Scott G Hansen et al.   NATURE MEDICINE

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

Immune responses after live attenuated influenza vaccination

(2018) Kristin G.-I. Mohn et al.   Human Vaccines & Immunotherapeutics

Incomplete Memories: The Natural Suppression of Tissue-Resident Memory CD8 T Cells in the Lung

(2018) Katie L. Reagin et al.   Frontiers in Immunology

The Transcriptional Regulation of Germinal Center Formation

(2018) Shuang Song et al.   Frontiers in Immunology

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers

(2018) Yu Tian et al.   OncoImmunology

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

(2017) A E Oja et al.   Mucosal Immunology

Respiratory syncytial virus elicits enriched CD8+ T lymphocyte responses in lung compared with blood in African green monkeys

(2017) Hualin Li et al.   PLoS One

Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails

(2017) Frank A.W. Verreck et al.   TUBERCULOSIS

Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8+ T Cells

(2017) Shiki Takamura   VIRAL IMMUNOLOGY

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing

(2017) Natalie E. Nieuwenhuizen et al.   Frontiers in Immunology

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

(2016) Carmen Gerlach et al.   IMMUNITY

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8 + T cells

(2016) Andreas Muschaweckh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

CD4+T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection

(2016) Taylor W. Foreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations

(2016) S. Sharpe et al.   TUBERCULOSIS

Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination

(2016) J. D. Galson et al.   Scientific Reports

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

(2015) Maximillian S. Habibi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evaluation of the Immunogenicity of Mycobacterium bovis BCG Delivered by Aerosol to the Lungs of Macaques

(2015) A. D. White et al.   Clinical and Vaccine Immunology

Effect of Varying Doses of a Monovalent H7N9 Influenza Vaccine With and Without AS03 and MF59 Adjuvants on Immune Response

(2015) Lisa A. Jackson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

(2015) Yu Adachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection

(2015) Sathit Pichyangkul et al.   JOURNAL OF IMMUNOLOGY

Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination

(2015) Giuseppe Lofano et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

(2015) Deepak Kaushal et al.   Nature Communications

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

(2015) Agnieszka Jozwik et al.   Nature Communications

The CD4 T cell response to respiratory syncytial virus infection

(2014) Allison F. Christiaansen et al.   IMMUNOLOGIC RESEARCH

Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2

(2014) K. Kai McKinstry et al.   Nature Communications

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nonreplicating Vaccines Can Protect African Green Monkeys From the Memphis 37 Strain of Respiratory Syncytial Virus

(2013) J. E. Eyles et al.   JOURNAL OF INFECTIOUS DISEASES

Protective and dysregulated T cell immunity in RSV infection

(2013) Peter J Openshaw et al.   Current Opinion in Virology

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The α4β1 Integrin in Localization ofMycobacterium tuberculosis–Specific T Helper Type 1 Cells to the Human Lung

(2010) Jessica R. Walrath et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased Airway T Regulatory Cells in Asthmatic Subjects

(2010) Lucy J.C. Smyth et al.   CHEST