Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies

(2017) Johann Pötzl et al.   INTERNATIONAL JOURNAL OF CANCER

Value of pH regulators in the diagnosis, prognosis and treatment of cancer

(2017) Sara Granja et al.   SEMINARS IN CANCER BIOLOGY

Novel “Elements” of Immune Suppression within the Tumor Microenvironment

(2017) Devikala Gurusamy et al.   Cancer Immunology Research

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells

(2016) Naoki Horikawa et al.   CLINICAL CANCER RESEARCH

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

Acidic tumor microenvironment in human melanoma

(2016) Ines Böhme et al.   Pigment Cell & Melanoma Research

Adenosine can thwart antitumor immune responses elicited by radiotherapy

(2016) Peter Vaupel et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

(2016) Vera Miranda-Gonçalves et al.   Oncotarget

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

(2016) Yu Jin Lee et al.   Oncotarget

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Commentary: A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Peter Vaupel et al.   Frontiers in Immunology

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality

(2015) A. McIntyre et al.   EMBO Molecular Medicine

Tumor angiogenesis, from foe to friend

(2015) L. B. Rivera et al.   SCIENCE

Intertwined regulation of angiogenesis and immunity by myeloid cells

(2015) Lee B. Rivera et al.   TRENDS IN IMMUNOLOGY

Intratumoral Myeloid Cells Regulate Responsiveness and Resistance to Antiangiogenic Therapy

(2015) Lee B. Rivera et al.   Cell Reports

Inhibition of Immune Checkpoints and Vascular Endothelial Growth Factor as Combination Therapy for Metastatic Melanoma: An Overview of Rationale, Preclinical Evidence, and Initial Clinical Data

(2015) Patrick A. Ott et al.   Frontiers in Oncology

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

(2014) C. L. Roland et al.   CANCER RESEARCH

The impact of the TIM gene family on tumor immunity and immunosuppression

(2013) Muhammad Baghdadi et al.   Cellular & Molecular Immunology

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors

(2012) Gabriele Multhoff et al.   Frontiers in Oncology

In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection

(2011) D. Marotta et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Physiology and Therapeutics of Vascular Endothelial Growth Factor in Tumor Immunosuppression

(2009) Benjamin Johnson et al.   CURRENT MOLECULAR MEDICINE

Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis

(2008) P. Vaupel   ONCOLOGIST