Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson’s Disease

Rotenone-Induced Model of Parkinson’s Disease: Beyond Mitochondrial Complex I Inhibition

(2023) María Teresa Ibarra-Gutiérrez et al.   MOLECULAR NEUROBIOLOGY

Pesticide exposure and the microbiota-gut-brain axis

(2023) Rie Matsuzaki et al.   ISME Journal

Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”

(2023) Tiago F. Outeiro et al.   MOVEMENT DISORDERS

Role of Astrocytes in Parkinson’s Disease Associated with Genetic Mutations and Neurotoxicants

(2023) Sanghoon Kim et al.   Cells

Gut microbiota: a non-target victim of pesticide-induced toxicity

(2023) Tusha Sharma et al.   Gut Microbes

A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

(2023) Kimberly C. Paul et al.   Nature Communications

Impact of occupational pesticide exposure on the human gut microbiome

(2023) Milla F. Brandao Gois et al.   Frontiers in Microbiology

Air Pollution and the Risk of Parkinson’s Disease: A Review

(2022) Hiromi Murata et al.   MOVEMENT DISORDERS

High Pesticide Exposure Events and Dream‐Enacting Behaviors Among US Farmers

(2022) Yaqun Yuan et al.   MOVEMENT DISORDERS

Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance

(2022) Ruixue Huang   Frontiers in Cellular and Infection Microbiology

Tau accelerates α-synuclein aggregation and spreading in Parkinson’s disease

(2022) Lina Pan et al.   BRAIN

Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson’s disease: Potential relevance to gut-brain axis inflammation in Parkinson’s disease pathogenesis

(2022) Bharathi N. Palanisamy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exposure to Pesticides Predicts Prodromal Feature of Parkinson's Disease: Public Health Implications

(2022) Sirwan K.L. Darweesh et al.   MOVEMENT DISORDERS

Clinical and imaging evidence of brain-first and body-first Parkinson's disease

(2022) Jacob Horsager et al.   NEUROBIOLOGY OF DISEASE

To the Gut Microbiome and Beyond: The Brain-First or Body-First Hypothesis in Parkinson’s Disease

(2022) Nathan D. Nuzum et al.   Frontiers in Microbiology

Effects of Glyphosate and Roundup™ on the mammalian nervous system: A review

(2022) Najm Alsadat Madani et al.   ENVIRONMENTAL RESEARCH

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

(2022) Ai Huey Tan et al.   Nature Reviews Neurology

Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment

(2022) Jessica Gama et al.   Frontiers in Microbiology

Update to the Treatment of Parkinson’s Disease Based on the Gut-Brain Axis Mechanism

(2022) Xiaohui Sun et al.   Frontiers in Neuroscience

Role of the Gut–Brain Axis, Gut Microbial Composition, Diet, and Probiotic Intervention in Parkinson’s Disease

(2022) Subramanian Thangaleela et al.   Microorganisms

Neurotoxicity of pesticides – A link to neurodegeneration

(2022) Balachandar Vellingiri et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice

(2022) Kaidong Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment

(2022) Angelica Varesi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The pyrethroids metabolite 3-phenoxybenzoic acid induces dopaminergic degeneration

(2022) Fang Wan et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms

(2022) Miriam H. Terkelsen et al.   Current Neurology and Neuroscience Reports

Microbiome–gut–brain dysfunction in prodromal and symptomatic Lewy body diseases

(2022) Sephira Ryman et al.   JOURNAL OF NEUROLOGY

Glyphosate affects the neurochemical phenotype of the intramural neurons in the duodenum in the pig

(2022) Katarzyna Palus et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets

(2022) Helena U. Zacharias et al.   Metabolites

Tau in the Pathophysiology of Parkinson’s Disease

(2021) Lina Pan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson’s disease.

(2021) Yogesh Bhattarai et al.   Gut Microbes

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

(2021) Per Borghammer   Journal of Parkinsons Disease

Parkinson’s Disease and Gut Microbiota

(2021) Masaaki Hirayama et al.   ANNALS OF NUTRITION AND METABOLISM

The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease

(2021) Briana R. De Miranda et al.   NEUROBIOLOGY OF DISEASE

Identification of mucin degraders of the human gut microbiota

(2021) Stefano Raimondi et al.   Scientific Reports

An Alternative Explanation for Alzheimer’s Disease and Parkinson’s Disease Initiation from Specific Antibiotics, Gut Microbiota Dysbiosis and Neurotoxins

(2021) Kevin Roe   NEUROCHEMICAL RESEARCH

Preventing Parkinson’s Disease: An Environmental Agenda

(2021) Briana R. De Miranda et al.   Journal of Parkinsons Disease

Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson's Disease in 204 Countries/Territories From 1990 to 2019

(2021) Zejin Ou et al.   Frontiers in Public Health

Fecal Calprotectin in Parkinson’s Disease and Multiple System Atrophy

(2021) Jia Wei Hor et al.   Journal of Movement Disorders

Impacts of early-life paraquat exposure on gut microbiota and body weight in adult mice

(2021) Yixi Li et al.   CHEMOSPHERE

Environmental factors in Parkinson’s disease: New insights into the molecular mechanisms

(2021) Xin Yuan et al.   TOXICOLOGY LETTERS

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Chemical Metabolism of Xenobiotics by Gut Microbiota

(2020) Radislav Nakov et al.   CURRENT DRUG METABOLISM

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

(2020) Collin Challis et al.   NATURE NEUROSCIENCE

Epithelial Toll-like receptors and their role in gut homeostasis and disease

(2020) Juan F. Burgueño et al.   Nature Reviews Gastroenterology & Hepatology

Leucine rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.

(2020) Zach Dwyer et al.   NEUROBIOLOGY OF AGING

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

(2020) Timothy R Sampson et al.   eLife

A Perspective on RNAi-Based Biopesticides

(2020) Stephen J. Fletcher et al.   Frontiers in Plant Science

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

(2020) Marie-Laure Arotcarena et al.   BRAIN

Parkinson disease and the immune system — associations, mechanisms and therapeutics

(2020) Eng-King Tan et al.   Nature Reviews Neurology

Gut microbiota differences between healthy older adults and individuals with Parkinson’s disease: A systematic review

(2020) Nathan D. Nuzum et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase

(2020) Yaoyu Pu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant Microbiome Engineering: Expected Benefits for Improved Crop Growth and Resilience

(2020) Inessa Arif et al.   TRENDS IN BIOTECHNOLOGY

Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications

(2020) Aristide Merola et al.   JOURNAL OF NEUROLOGY

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance

(2020) R. Alberto Travagli et al.   Nature Reviews Gastroenterology & Hepatology

Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP

(2020) Yaoyu Pu et al.   NEUROSCIENCE LETTERS

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson’s Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis

(2020) Yuanhui Zhu et al.   ACS Chemical Neuroscience

Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study

(2020) Jacob Horsager et al.   BRAIN

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

(2020) Kanmani Suganya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota: A Key Factor in the Host Health Effects Induced by Pesticide Exposure?

(2020) Zhiyuan Meng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alpha Synuclein Connects the Gut-Brain Axis in Parkinson’s Disease Patients – A View on Clinical Aspects, Cellular Pathology and Analytical Methodology

(2020) Eva Schaeffer et al.   Frontiers in Cell and Developmental Biology

Pesticide use and incident Parkinson's disease in a cohort of farmers and their spouses

(2020) Srishti Shrestha et al.   ENVIRONMENTAL RESEARCH

Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease

(2020) Laura Benvenuti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug–Exposome Interactions: The Next Frontier in Precision Medicine

(2020) Manuel Pristner et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Classification of the glyphosate target enzyme (5-enolpyruvylshikimate-3-phosphate synthase) for assessing sensitivity of organisms to the herbicide

(2020) Lyydia Leino et al.   JOURNAL OF HAZARDOUS MATERIALS

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia

(2019) Judong Kim et al.   PLoS One

Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month

(2019) Nina Iszatt et al.   Microbiome

Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson’s Disease in Mouse Midbrain

(2019) Joseph Kochmanski et al.   TOXICOLOGICAL SCIENCES

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

Neurotoxicity of polychlorinated biphenyls and related organohalogens

(2019) Isaac N. Pessah et al.   ACTA NEUROPATHOLOGICA

Altered gastric tone and motility response to brainstem dopamine in a rat model of parkinsonism

(2019) Cecilia Bove et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diagnostic utility of gut α-synuclein in Parkinson’s disease: A systematic review and meta-analysis

(2019) Jin Bu et al.   BEHAVIOURAL BRAIN RESEARCH

Pyrethroid exposure and neurotoxicity: a mechanistic approach

(2019) Hamidreza Mohammadi et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies

(2019) Antonina Kouli et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut microbiota: An underestimated and unintended recipient for pesticide-induced toxicity

(2019) Xianling Yuan et al.   CHEMOSPHERE

Recent Developments in LRRK2-Targeted Therapy for Parkinson’s Disease

(2019) Ye Zhao et al.   DRUGS

Parkinsonism Relating to Intoxication with Glyphosate

(2019) Makoto Eriguchi et al.   INTERNAL MEDICINE

Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

(2019) Chris Rudyk et al.   Journal of Neuroinflammation

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain

(2019) Yaoyu Pu et al.   Aging-US

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer

(2019) Ruth E. Musgrove et al.   JOURNAL OF CLINICAL INVESTIGATION

Update of the MDS research criteria for prodromal Parkinson's disease

(2019) Sebastian Heinzel et al.   MOVEMENT DISORDERS

Role of Astrocytes in Manganese Neurotoxicity Revisited

(2019) Tao Ke et al.   NEUROCHEMICAL RESEARCH

Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis

(2019) Per Borghammer et al.   Journal of Parkinsons Disease

Paraquat Degradation From Contaminated Environments: Current Achievements and Perspectives

(2019) Yaohua Huang et al.   Frontiers in Microbiology

Occupational exposure to chronic ionizing radiation increases risk of Parkinson's disease incidence in Russian Mayak workers

(2019) Tamara V Azizova et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism

(2019) C. Bove et al.   NEUROSCIENCE

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

(2019) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

Twice subacute MPTP administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in PD mice

(2019) Wenjun Xie et al.   NEUROTOXICOLOGY

Gut microbiota and neurological effects of glyphosate

(2019) Lola Rueda-Ruzafa et al.   NEUROTOXICOLOGY

The gut microbiome: an orchestrator of xenobiotic metabolism

(2019) Stephanie L. Collins et al.   Acta Pharmaceutica Sinica B

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

(2018) Xian-Si Zeng et al.   ASN Neuro

Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy

(2018) Jiayan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

The Ramazzini Institute 13-week pilot study on glyphosate and Roundup administered at human-equivalent dose to Sprague Dawley rats: effects on the microbiome

(2018) Qixing Mao et al.   Environmental Health

Neurotransmitter changes in rat brain regions following glyphosate exposure

(2018) María-Aránzazu Martínez et al.   ENVIRONMENTAL RESEARCH

Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson’s Disease

(2018) Valentina Caputi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity

(2018) Anne M. Nixon et al.   JOURNAL OF NEUROCHEMISTRY

Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease

(2018) Madelyn C. Houser et al.   MOVEMENT DISORDERS

Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson’s disease

(2018) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice

(2018) Yassine Aitbali et al.   NEUROTOXICOLOGY AND TERATOLOGY

Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease

(2018) Andreas Schwiertz et al.   PARKINSONISM & RELATED DISORDERS

Human Gut Microbiome: Function Matters

(2018) Anna Heintz-Buschart et al.   TRENDS IN MICROBIOLOGY

Vulnerability of glia and vessels of rat substantia nigra in rotenone Parkinson model

(2018) Sanaa A. M. Elgayar et al.   ULTRASTRUCTURAL PATHOLOGY

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Longitudinal Analysis of Fecal Microbiome and Pathologic Processes in a Rotenone Induced Mice Model of Parkinson’s Disease

(2018) Xiaodong Yang et al.   Frontiers in Aging Neuroscience

The Parkinson Pandemic—A Call to Action

(2018) E. Ray Dorsey et al.   JAMA Neurology

Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice

(2018) Yi Zhang et al.   ENVIRONMENTAL TOXICOLOGY

Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson’s Disease

(2018) Feng Lai et al.   NEUROCHEMICAL RESEARCH

Glyphosate perturbs the gut microbiota of honey bees

(2018) Erick V. S. Motta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Gut bacterial composition in a mouse model of Parkinson’s disease

(2018) P. Perez-Pardo et al.   Beneficial Microbes

Enteric alpha-synuclein expression is increased in Crohn’s disease

(2018) Alice Prigent et al.   ACTA NEUROPATHOLOGICA

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

(2018) Paula Perez-Pardo et al.   GUT

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

(2018) Michela Barichella et al.   MOVEMENT DISORDERS

K-variant BCHE and pesticide exposure: Gene-environment interactions in a case–control study of Parkinson’s disease in Egypt

(2018) Thomas W. Rösler et al.   Scientific Reports

Estimated Residential Exposure to Agricultural Chemicals and Premature Mortality by Parkinson’s Disease in Washington State

(2018) Mariah Caballero et al.   International Journal of Environmental Research and Public Health

The Emerging Evidence of the Parkinson Pandemic

(2018) E. Ray Dorsey et al.   Journal of Parkinsons Disease

Effects of Deltamethrin on striatum and hippocampus mitochondrial integrity and the protective role of Quercetin in rats

(2017) Salim Gasmi et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Assessment of pesticide contamination in Akkar groundwater, northern Lebanon

(2017) Chbib Chaza et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Food contact materials and gut health: Implications for toxicity assessment and relevance of high molecular weight migrants

(2017) Ksenia J. Groh et al.   FOOD AND CHEMICAL TOXICOLOGY

A Nigro−Vagal Pathway Controls Gastric Motility and Is Affected in a Rat Model of Parkinsonism

(2017) Laura Anselmi et al.   GASTROENTEROLOGY

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

(2017) Ethan Stolzenberg et al.   Journal of Innate Immunity

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice

(2017) Nicolas Naudet et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Valery L Feigin et al.   LANCET NEUROLOGY

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet

(2017) Paula Perez-Pardo et al.   NUTRITIONAL NEUROSCIENCE

Parkinson’s disease and occupational exposures: a systematic literature review and meta-analyses

(2017) Lars-Gunnar Gunnarsson et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation

(2017) Liyan Hou et al.   TOXICOLOGY

Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress

(2017) Daiane Cattani et al.   TOXICOLOGY

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

(2017) J. R. Bedarf et al.   Genome Medicine

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

(2016) Morten Gersel Stokholm et al.   ANNALS OF NEUROLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Changes on fecal microbiota in rats exposed to permethrin during postnatal development

(2016) Cinzia Nasuti et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Investigations on the possible impact of a glyphosate-containing herbicide on ruminal metabolism and bacteria in vitro by means of the ‘Rumen Simulation Technique’

(2016) S. Riede et al.   JOURNAL OF APPLIED MICROBIOLOGY

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

(2016) J. A. Bayliss et al.   JOURNAL OF NEUROSCIENCE

Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015

(2016) Stephen S Lim et al.   LANCET

Potential role of organochlorine pesticides in the pathogenesis of neurodevelopmental, neurodegenerative, and neurobehavioral disorders: A review

(2016) Seyed Soheil Saeedi Saravi et al.   LIFE SCIENCES

Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

(2016) G. Martella et al.   NEUROBIOLOGY OF DISEASE

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

(2016) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME® Model

(2016) Julie Reygner et al.   International Journal of Environmental Research and Public Health

Association between Parkinson’s Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis

(2016) Charles B. Breckenridge et al.   PLoS One

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection

(2015) Elzbieta Janda et al.   Autophagy

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Control of Brain Development, Function, and Behavior by the Microbiome

(2015) Timothy R. Sampson et al.   Cell Host & Microbe

Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease

(2015) Melissa Furlong et al.   ENVIRONMENT INTERNATIONAL

Parkinson’s disease and enhanced inflammatory response

(2015) Iva Stojkovska et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The scientific bases to consider Parkinson's disease an occupational disease in agriculture professionals exposed to pesticides in France

(2015) Alexis Elbaz et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Chlorpyrifos Exposure During Perinatal Period Impacts Intestinal Microbiota Associated with Delay of Maturation of Digestive Tract in Rats

(2015) Claire Joly Condette et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

MDS research criteria for prodromal Parkinson's disease

(2015) Daniela Berg et al.   MOVEMENT DISORDERS

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Usefulness of Genetic Testing in PD and PD Trials: A Balanced Review

(2015) Thomas Gasser   Journal of Parkinsons Disease

Paraquat Prohibition and Change in the Suicide Rate and Methods in South Korea

(2015) Woojae Myung et al.   PLoS One

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

The Influence of Glyphosate on the Microbiota and Production of Botulinum Neurotoxin During Ruminal Fermentation

(2014) Wagis Ackermann et al.   CURRENT MICROBIOLOGY

Enteric GFAP expression and phosphorylation in Parkinson's disease

(2014) Thomas Clairembault et al.   JOURNAL OF NEUROCHEMISTRY

The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PDStudy)

(2014) Claustre Pont-Sunyer et al.   MOVEMENT DISORDERS

Enteric glial cells: New players in Parkinson's disease?

(2014) Thomas Clairembault et al.   MOVEMENT DISORDERS

The neurobiological basis of cognitive impairment in Parkinson's disease

(2014) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Glyphosate suppresses the antagonistic effect of Enterococcus spp. on Clostridium botulinum

(2013) Monika Krüger et al.   ANAEROBE

Environmental Toxins and Parkinson's Disease

(2013) Samuel M. Goldman   Annual Review of Pharmacology and Toxicology

Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

(2013) Anthony Samsel et al.   Entropy

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease

(2013) Leo P. Kelly et al.   MOVEMENT DISORDERS

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

p38MAPK/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson’s disease

(2013) Feng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of oral administration of rotenone on gastrointestinal functions in mice

(2013) M. Tasselli et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Exposure to pesticides or solvents and risk of Parkinson disease

(2013) G. Pezzoli et al.   NEUROLOGY

Dietary fat intake, pesticide use, and Parkinson's disease

(2013) Freya Kamel et al.   PARKINSONISM & RELATED DISORDERS

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Gut Microbiota Composition in Male Rat Models under Different Nutritional Status and Physical Activity and Its Association with Serum Leptin and Ghrelin Levels

(2013) María Isabel Queipo-Ortuño et al.   PLoS One

Meta-analysis of early nonmotor features and risk factors for Parkinson disease

(2012) Alastair J. Noyce et al.   ANNALS OF NEUROLOGY

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Immunoregulation by the gut microbiota

(2012) Junko Nishio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Effect of Glyphosate on Potential Pathogens and Beneficial Members of Poultry Microbiota In Vitro

(2012) Awad A. Shehata et al.   CURRENT MICROBIOLOGY

Occupational exposure to pesticides and Parkinson's disease: A systematic review and meta-analysis of cohort studies

(2012) Geneviève Van Maele-Fabry et al.   ENVIRONMENT INTERNATIONAL

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

(2012) Paula Desplats et al.   Molecular Neurodegeneration

Genetic modification of the association of paraquat and Parkinson's disease

(2012) Samuel M. Goldman et al.   MOVEMENT DISORDERS

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease

(2012) P.-C. Lee et al.   NEUROLOGY

Pesticide exposure and Parkinson's disease: Epidemiological evidence of association

(2012) Carmen Freire et al.   NEUROTOXICOLOGY

Glyphosate induced cell death through apoptotic and autophagic mechanisms

(2012) Ya-xing Gui et al.   NEUROTOXICOLOGY AND TERATOLOGY

Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways

(2012) Jonathan Wills et al.   PLoS One

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Head injury, alpha-synuclein Rep1, and Parkinson's disease

(2011) Samuel M. Goldman et al.   ANNALS OF NEUROLOGY

Is Pesticide Use Related to Parkinson Disease? Some Clues to Heterogeneity in Study Results

(2011) Marianne van der Mark et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

(2011) Karin Wirdefeldt et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

HFE Gene Variants Affect Iron in the Brain

(2011) Wint Nandar et al.   JOURNAL OF NUTRITION

Biochemical and toxicological evidence of neurological effects of pesticides: The example of Parkinson's disease

(2011) A. Moretto et al.   NEUROTOXICOLOGY

Parkinsonism after chronic occupational exposure to glyphosate

(2011) Gang Wang et al.   PARKINSONISM & RELATED DISORDERS

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Metal Emissions and Urban Incident Parkinson Disease: A Community Health Study of Medicare Beneficiaries by Using Geographic Information Systems

(2010) A. W. Willis et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Association of Cumulative Lead Exposure with Parkinson’s Disease

(2010) Marc G. Weisskopf et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson’s disease?

(2010) Marcus M. Unger et al.   JOURNAL OF NEUROLOGY

Environmental Neurotoxic Pesticide Increases Histone Acetylation to Promote Apoptosis in Dopaminergic Neuronal Cells: Relevance to Epigenetic Mechanisms of Neurodegeneration

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Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

(2010) Beth Arnold et al.   NEUROBIOLOGY OF DISEASE

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(2009) Christopher H. Hawkes et al.   Annals of the New York Academy of Sciences

Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate

(2009) Nahla S. El-Shenawy   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

(2009) James G. Greene et al.   EXPERIMENTAL NEUROLOGY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

(2009) Pier Giorgio Mastroberardino et al.   NEUROBIOLOGY OF DISEASE

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE

From Manganism to Manganese-Induced Parkinsonism: A Conceptual Model Based on the Evolution of Exposure

(2009) Roberto G. Lucchini et al.   NEUROMOLECULAR MEDICINE

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

(2009) Francesca Cicchetti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Invited Article: Nervous system pathology in sporadic Parkinson disease

(2008) H. Braak et al.   NEUROLOGY