Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

(2018) Norihito Uemura et al.   Molecular Neurodegeneration

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

(2018) Fredric P. Manfredsson et al.   NEUROBIOLOGY OF DISEASE

Is constipation in Parkinson's disease caused by gut or brain pathology?

(2018) Per Borghammer   PARKINSONISM & RELATED DISORDERS

Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease

(2018) Jared T. Hinkle et al.   PARKINSONISM & RELATED DISORDERS

Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies

(2017) Mathieu Bourdenx et al.   PROGRESS IN NEUROBIOLOGY

Objective Colonic Dysfunction is Far more Prevalent than Subjective Constipation in Parkinson’s Disease: A Colon Transit and Volume Study

(2017) Karoline Knudsen et al.   Journal of Parkinsons Disease

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice

(2015) Michael Helwig et al.   BRAIN

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Targeting β-arrestin2 in the treatment of l-DOPA–induced dyskinesia in Parkinson’s disease

(2015) Nikhil M. Urs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

(2015) Mathieu Bourdenx et al.   Acta Neuropathologica Communications

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Novel One-step Immunoassays to Quantify α-Synuclein

(2012) Michael Bidinosti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking

(2012) Gregory Porras et al.   JOURNAL OF CLINICAL INVESTIGATION

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia

(2010) S. Fasano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviral Overexpression of GRK6 Alleviates L-Dopa-Induced Dyskinesia in Experimental Parkinson's Disease

(2010) M. R. Ahmed et al.   Science Translational Medicine