Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis

Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?

(2019) David P. Breen et al.   MOVEMENT DISORDERS

Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease

(2019) Eduardo De Pablo-Fernández et al.   JAMA Neurology

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies – current issues and future directions

(2019) Lauren Walker et al.   JOURNAL OF NEUROCHEMISTRY

Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder

(2019) Zhemin Huang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oral and intravenous transmission of α-synuclein fibrils to mice

(2019) Stephanie Lohmann et al.   ACTA NEUROPATHOLOGICA

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Peripheral and central autonomic nervous system: does the sympathetic or parasympathetic nervous system bear the brunt of the pathology during the course of sporadic PD?

(2018) Satoshi Orimo et al.   CELL AND TISSUE RESEARCH

ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

(2018) W. Peelaerts et al.   CELL AND TISSUE RESEARCH

The enteric nervous system in PD: gateway, bystander victim, or source of solutions

(2018) Kathleen Shannon et al.   CELL AND TISSUE RESEARCH

Is Braak staging valid for all types of Parkinson’s disease?

(2018) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

(2018) Karoline Knudsen et al.   LANCET NEUROLOGY

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

(2018) Norihito Uemura et al.   Molecular Neurodegeneration

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

(2018) Fredric P. Manfredsson et al.   NEUROBIOLOGY OF DISEASE

Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis

(2018) David R. Shprecher et al.   PARKINSONISM & RELATED DISORDERS

Presynaptic dopaminergic neuroimaging in REM sleep behavior disorder: A systematic review and meta-analysis

(2018) Matteo Bauckneht et al.   SLEEP MEDICINE REVIEWS

When Do α-Synucleinopathies Start? An Epidemiological Timeline

(2018) Rodolfo Savica et al.   JAMA Neurology

Myocardial MIBG scintigraphy in genetic Parkinson’s disease as a model for Lewy body disorders

(2018) Iñigo Gabilondo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

The vermiform appendix impacts the risk of developing Parkinson’s disease

(2018) Bryan A. Killinger et al.   Science Translational Medicine

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

(2018) Kenneth Marek et al.   Annals of Clinical and Translational Neurology

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

(2017) Ethan Stolzenberg et al.   Journal of Innate Immunity

Parkinson's Disease Is Not Simply a Prion Disorder

(2017) D. James Surmeier et al.   JOURNAL OF NEUROSCIENCE

Prying into the Prion Hypothesis for Parkinson's Disease

(2017) Patrik Brundin et al.   JOURNAL OF NEUROSCIENCE

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder

(2017) Sanne K. Meles et al.   MOVEMENT DISORDERS

How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology

(2017) Per Borghammer   MOVEMENT DISORDERS

Idiopathic REM sleep behaviour disorder and neurodegeneration — an update

(2017) Birgit Högl et al.   Nature Reviews Neurology

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease

(2017) Laurène Leclair-Visonneau et al.   NEUROLOGY

Decreased intestinal acetylcholinesterase in early Parkinson disease

(2017) Tatyana D. Fedorova et al.   NEUROLOGY

The Threshold Theory for Parkinson's Disease

(2017) Simone Engelender et al.   TRENDS IN NEUROSCIENCES

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

(2016) Morten Gersel Stokholm et al.   ANNALS OF NEUROLOGY

Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease

(2016) Michal Rolinski et al.   BRAIN

The coeruleus/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder

(2016) Mickael Ehrminger et al.   BRAIN

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

A case series of REM sleep behavior disorder in pure autonomic failure

(2016) Mitchell G. Miglis et al.   CLINICAL AUTONOMIC RESEARCH

Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?

(2016) J.-S. Kim et al.   EUROPEAN JOURNAL OF NEUROLOGY

[123]FP-CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies

(2016) J. J. van der Zande et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation

(2016) Sara Breid et al.   JOURNAL OF VIROLOGY

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

(2016) Jacob I. Ayers et al.   JOURNAL OF VIROLOGY

Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

(2016) Dolores Vilas et al.   LANCET NEUROLOGY

Neuropathological basis of nonmotor manifestations of Parkinson's disease

(2016) Charles H. Adler et al.   MOVEMENT DISORDERS

Nonmotor features of Parkinson's disease subtypes

(2016) Connie Marras et al.   MOVEMENT DISORDERS

High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA

(2016) Justus M. Kebschull et al.   NEURON

Non motor subtypes and Parkinson's disease

(2016) Anna Sauerbier et al.   PARKINSONISM & RELATED DISORDERS

Variation in Recent Onset Parkinson’s Disease: Implications for Prodromal Detection

(2016) Diane M.A. Swallow et al.   Journal of Parkinsons Disease

Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies

(2016) Anne-Gaëlle Corbillé et al.   Acta Neuropathologica Communications

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Toshiki Uchihara et al.   ACTA NEUROPATHOLOGICA

A new dopaminergic nigro-olfactory projection

(2015) Günter U. Höglinger et al.   ACTA NEUROPATHOLOGICA

Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease

(2015) Vincenzo Donadio et al.   ANNALS OF NEUROLOGY

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

REM sleep behavior disorder and neuropathology in Parkinson's disease

(2015) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Multisystem Lewy body disease and the other parkinsonian disorders

(2015) J William Langston et al.   NATURE GENETICS

Parkinson risk in idiopathic REM sleep behavior disorder: Preparing for neuroprotective trials

(2015) R. B. Postuma et al.   NEUROLOGY

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder

(2015) Fabienne S. Sprenger et al.   NEUROLOGY

Familial Parkinson’s Disease/Parkinsonism

(2015) Hiroyuki Tomiyama et al.   Biomed Research International

New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression

(2015) Seyed-Mohammad Fereshtehnejad et al.   JAMA Neurology

Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

(2015) Hiroyuki Sumikura et al.   Acta Neuropathologica Communications

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET

(2014) Trine Gjerløff et al.   BRAIN

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease

(2013) Daniel García-Lorenzo et al.   BRAIN

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study

(2013) Alex Iranzo et al.   LANCET NEUROLOGY

Clinicogenetic study of GBA mutations in patients with familial Parkinson's disease

(2013) Yuanzhe Li et al.   NEUROBIOLOGY OF AGING

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

(2012) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Cerebral Glucose Metabolic Features of Parkinson Disease and Incident Dementia: Longitudinal Study

(2011) N. I. Bohnen et al.   JOURNAL OF NUCLEAR MEDICINE

Autonomic dysfunction in PD: A window to early detection?

(2011) David S. Goldstein et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the α-synuclein gene (SNCA)

(2010) B. Tijero et al.   CLINICAL AUTONOMIC RESEARCH

Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease

(2010) Kenichi Kashihara et al.   PARKINSONISM & RELATED DISORDERS

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat

(2009) Robert J. Phillips et al.   EXPERIMENTAL NEUROLOGY

Subcortical elevation of metabolism in Parkinson's disease — A critical reappraisal in the context of global mean normalization

(2009) Per Borghammer et al.   NEUROIMAGE

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

(2008) Laura Parkkinen et al.   ACTA NEUROPATHOLOGICA

Abnormal regional brain function in Parkinson's disease: truth or fiction?

(2008) Yilong Ma et al.   NEUROIMAGE

Artefactual subcortical hyperperfusion in PET studies normalized to global mean: Lessons from Parkinson’s disease

(2008) Per Borghammer et al.   NEUROIMAGE

Patterns and stages of  -synucleinopathy: Relevance in a population-based cohort

(2008) J. Zaccai et al.   NEUROLOGY

The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease

(2008)   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of α-synuclein staging

(2008) M. E. Kalaitzakis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes

(2008) Kazuko Hasegawa et al.   PARKINSONISM & RELATED DISORDERS

Myocardial123metaiodobenzylguanidine uptake in genetic Parkinson's disease

(2007) Aldo Quattrone et al.   MOVEMENT DISORDERS