Parkinson’s disease and enhanced inflammatory response

Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism

(2014) Sha-Sha Chen et al.   EXPERIMENTAL NEUROLOGY

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

(2014) Isabella Russo et al.   Journal of Neuroinflammation

Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease

(2014) Maciej Świątkiewicz et al.   Pharmacological Reports

A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets

(2013) Chenere P. Ramsey et al.   EXPERIMENTAL NEUROLOGY

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 −/− mice

(2013) Thi A Nguyen et al.   Journal of Neuroinflammation

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain

(2013) Geeta Ramesh et al.   MEDIATORS OF INFLAMMATION

Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease

(2013) Juliet M. Taylor et al.   NEUROCHEMISTRY INTERNATIONAL

Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol

(2013) Mohammad Moshahid Khan et al.   NEUROCHEMISTRY INTERNATIONAL

Discontinuation of statin therapy associates with Parkinson disease: A population-based study

(2013) Y.-C. Lee et al.   NEUROLOGY

Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats

(2013) Milind Geed et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Intranasal LPS-Mediated Parkinson’s Model Challenges the Pathogenesis of Nasal Cavity and Environmental Toxins

(2013) Qing He et al.   PLoS One

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

Alpha-Synuclein Expression in Patients with Parkinson's Disease: A Clinician's Perspective

(2013) Han-Joon Kim   Experimental Neurobiology

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse

(2012) Garima Srivastava et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inactivation ofPink1Genein VivoSensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes,ParkinorDJ-1

(2012) M. Emdadul Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: IL-13R 1 Expression in Dopaminergic Neurons Contributes to Their Oxidative Stress-Mediated Loss following Chronic Peripheral Treatment with Lipopolysaccharide

(2012) B. E. Morrison et al.   JOURNAL OF IMMUNOLOGY

A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats

(2012) Yan Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Full and partial peroxisome proliferation-activated receptor-gamma agonists, but not delta agonist, rescue of dopaminergic neurons in the 6-OHDA Parkinsonian model is associated with inhibition of microglial activation and MMP expression

(2012) M. Sadeghian et al.   JOURNAL OF NEUROIMMUNOLOGY

Anti-apoptotic and Anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's Rat model

(2012) Pallavi Shrivastava et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor

(2012) Mahmoud M. Iravani et al.   NEUROSCIENCE LETTERS

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

(2011) Paramita Chakrabarty et al.   NATURE NEUROSCIENCE

Use of ibuprofen and risk of Parkinson disease

(2011) X. Gao et al.   NEUROLOGY

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

Paraquat and Parkinson's disease

(2010) C Berry et al.   CELL DEATH AND DIFFERENTIATION

Antioxidative and Anti-Inflammatory Protection from Carnosine in the Striatum of MPTP-Treated Mice

(2010) Shih-Jei Tsai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Dopamine Neuron Stimulating Actions of a GDNF Propeptide

(2010) Luke H. Bradley et al.   PLoS One

Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1

(2009) Jens Waak et al.   FASEB JOURNAL

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

(2009) Philipp J. Kahle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice

(2009) Randy L. Hunter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Striatal Neuroinflammation Promotes Parkinsonism in Rats

(2009) Dong-Young Choi et al.   PLoS One

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

(2008) María del Carmen Hernández-Romero et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE