Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer

Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain

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Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

(2018) Jaime N. Guzman et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

(2018) Owen Scudamore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

A Nigro−Vagal Pathway Controls Gastric Motility and Is Affected in a Rat Model of Parkinsonism

(2017) Laura Anselmi et al.   GASTROENTEROLOGY

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations

(2017) Ayelet Avin et al.   Nature Communications

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

(2016) Saurav Brahmachari et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice

(2015) Michael Helwig et al.   BRAIN

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis

(2015) Ritwik Burai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury

(2015) Ayse Ulusoy et al.   Acta Neuropathologica Communications

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Tyrosine phosphorylation profiling via in situproximity ligation assay

(2014) Lioudmila Elfineh et al.   BMC CANCER

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

(2014) Hélène Hall et al.   BRAIN

The Brainstem Pathologies of Parkinson's Disease and Dementia with Lewy Bodies

(2014) Kay Seidel et al.   BRAIN PATHOLOGY

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

(2014) Eun-Jin Bae et al.   Nature Communications

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

(2013) Stefan Schildknecht et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

(2012) Eric C. Freundt et al.   ANNALS OF NEUROLOGY

Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease

(2012) Joshua A Goldberg et al.   NATURE NEUROSCIENCE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of antibodies that selectively detect α-synuclein in pathological inclusions

(2008) Elisa A. Waxman et al.   ACTA NEUROPATHOLOGICA

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE