Article
Public, Environmental & Occupational Health
Kanyapak Kohsuwan, Unchisa Intayoung, Supakit Khacha-ananda, Ratana Sapbamrer, Nut Koonrungsesomboon, Sujitra Techatoei, Klintean Wunnapuk
Summary: This study determined the toxicokinetics of glyphosate and its metabolite in urine among maize farmers from northern Thailand and studied the effects of personal protective equipment usage and farmer behavior on urinary glyphosate levels.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Maite De Maria, Cecilia Silva-Sanchez, Kevin J. Kroll, Michael T. Walsh, Mohammad-Zaman Nouri, Margaret E. Hunter, Monica Ross, Tonya M. Clauss, Nancy D. Denslow
Summary: The study found that glyphosate concentration in Florida manatee samples has significantly increased from 2009 to 2019, and glyphosate and AMPA were ubiquitous in water bodies. Higher concentrations of glyphosate and AMPA were observed in South Florida than in Crystal River.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Federico Meloni, Giannina Satta, Marina Padoan, Andrea Montagna, Ilaria Pilia, Alessandra Argiolas, Sara Piro, Corrado Magnani, Angela Gambelunghe, Giacomo Muzi, Giovanni Maria Ferri, Luigi Vimercati, Roberta Zanotti, Aldo Scarpa, Mariagrazia Zucca, Sara De Matteis, Marcello Campagna, Lucia Miligi, Pierluigi Cocco
Summary: The study found that occupational exposure to glyphosate may increase the risk of follicular lymphoma, but not other types of lymphoma or non-Hodgkin lymphoma.
ENVIRONMENTAL HEALTH
(2021)
Article
Marine & Freshwater Biology
Maite De Maria, Kevin J. Kroll, Fahong Yu, Mohammad-Zaman Nouri, Cecilia Silva-Sanchez, Juan Guillermo Perez, David A. Moraga Amador, Yanping Zhang, Mike T. Walsh, Nancy D. Denslow
Summary: Glyphosate, the most widely used herbicide globally, has the potential to cause endocrine disruption and organ damage in aquatic wildlife. This study found that exposure to glyphosate and the aquatic herbicide Rodeo (R) resulted in significant changes in hormone levels and gene expression in largemouth bass.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Fernanda de Maria Serra, Jose Luiz Santos Parizi, Gisele Aparecida Sales de Mello Odorizzi, Grace Mitiko Rosati Hori Sato, Isabela Bocardi Patrao, Pedro Henrique Nahas Chagas, Fabiola de Azevedo Mello, Gisele Alborghetti Nai
Summary: This study found that GBH exposure in rats leads to adverse effects on the digestive tract, including oral allergies, dysplastic lesions in the esophagus and intestine, and genotoxic potential.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Marine & Freshwater Biology
Jessy Le Du-Carree, Thierry Morin, Morgane Danion
Summary: The study found that exposure of rainbow trout to a concentration of 1 mu g L-1 of glyphosate for 10 months did not significantly impact their overall health, including during the spawning period, regardless of whether the pure active substance or two GBH formulations were used. However, immunological disturbances observed may require further investigation as they could have a significant impact in response to infectious stress.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Maria Solange Vera, Maria Alcira Trinelli
Summary: The study evaluated the recovery potential of freshwater periphyton from glyphosate exposure and found that the exposure concentration modulates the recovery process. It is the first to investigate the recovery of periphyton exposed to the most commonly used herbicide in the world in herbicide-free water, highlighting the need for more research on the recovery potential of freshwater ecosystems and aquatic communities after glyphosate contamination.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Laura Maria Antonangeli, Saniya Kenzhebekova, Claudio Colosio
Summary: This study evaluates new research conducted between 2009 and 2021 to understand the neurobehavioral risk associated with long-term insecticide exposure. After reviewing 86 scientific papers, contradictory and difficult-to-compare results were found, and the presence of a previous poisoning episode and hospitalization hampered confirmation of a causal association with insecticide exposure in most studies that showed neurobehavioral impairment. Interestingly, applicators who did not wear personal protective equipment performed worse on neurobehavioral tests among the highly exposed groups. There is sufficient evidence to suggest that prenatal organophosphate exposure may increase the risk of ADHD in children.
Article
Environmental Sciences
Anthony Estienne, Mathias Freville, Guillaume Bourdon, Christelle Rame, Joel Delaveau, Christophe Rat, Marine Chahnamian, Aurelien Brionne, Pascal Chartrin, Hans Adriensen, Francois Lecompte, Pascal Froment, Joelle Dupont
Summary: This study investigated the effects of dietary exposure to glyphosate-based herbicides (GBH) on the fertility and embryo development in chickens. The results showed that chronic exposure to GBH at a concentration lower than the safety level led to severe early embryonic mortality and delayed embryonic development, but these effects were reversible within two weeks after the end of exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Ryota Ojiro, Hiromu Okano, Yasunori Takahashi, Kazumi Takashima, Qian Tang, Shunsuke Ozawa, Xinyu Zou, Gye-Hyeong Woo, Makoto Shibutani
Summary: Increasing evidence suggests that glyphosate-based herbicides (GBHs) can induce developmental neurotoxicity. This study investigated the effects of glyphosate (GlyP) and GBH exposure on hippocampal neurogenesis in rats. The results showed that both GlyP and GBH suppressed neural progenitor cell proliferation, altered the number of granule cells, and increased synaptic plasticity in the hippocampus. These effects were associated with increased sensitivity to oxidative stress and disruption of neurogenesis. GBH had a stronger impact on adult age, suggesting that surfactants in GBH may enhance the neurotoxicity of GlyP.
Article
Environmental Sciences
Imane Berni, Aziza Menouni, Matteo Creta, Ibrahim El Ghazi, Radu-Corneliu Duca, Lode Godderis, Samir El Jaafari
Summary: This study aimed to evaluate the levels of glyphosate and its metabolite AMPA in Moroccan children, identify predictors, and conduct a risk assessment. The study found that glyphosate and AMPA were detected in the urine of 73% and 75% of children, respectively, with higher concentrations in younger children and those living near pesticide spraying fields. Factors such as drinking water source and household income were also associated with AMPA concentration. The health risk assessment showed low risk for the target population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Markel Erburu-Iriarte, Patricia Rodrigo-Armenteros, Inigo Oyarzun-Irazu, Ines Aranzabal-Alustiza, Saul Silvarrey-Rodriguez, Lander Anton-Mendez, Juan Carlos Garcia-Monco
Summary: A 56-year-old woman's excessive fear of contracting COVID-19 led to inappropriate use of methanol to disinfect her mask, resulting in chronic methanol intoxication with severe cognitive and parkinsonian symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Subramaniam Jayanthi, Bruce Ladenheim, Patricia Sullivan, Michael T. McCoy, Irina N. Krasnova, David S. Goldstein, Jean Lud Cadet
Summary: Perturbations in striatal dopamine homeostasis may contribute to METH use disorder. Rats exposed to footshocks after long-term METH intake showed decreased intake when given a DA D1 receptor antagonist. Compulsive METH takers exhibited abnormal DA metabolism and decreased protein levels. These findings are consistent with studies on human METH users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yudong Xu, Huihui Hong, Xiqin Lin, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Gaofeng Mao, Rongrong Hao, Ping Deng, Zhengping Yu, Huifeng Pi, Yong Cheng, Zhou Zhou
Summary: This study revealed that perturbed sphingomyelin lipid metabolism is related to the pathogenesis of Parkinsonism and Cd neurotoxicity, partially compensated for the deficiency in particular metabolic biomarkers for Parkinsonism in relation to Cd exposure, and emphasized the necessity of reducing Cd exposure at the population level.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Germano Lanzarin, Carlos Venancio, Luis M. Felix, Sandra Monteiro
Summary: Glyphosate-based herbicides are widely used globally, but the study found that acute exposure to RF in zebrafish larvae at higher concentrations can lead to oxidative stress and cell death, without affecting inflammation or antioxidant enzyme activity. Further research is needed to understand the molecular mechanisms underlying these effects.
Article
Chemistry, Multidisciplinary
Qian Zhang, Qingxiang Song, Xiao Gu, Mengna Zheng, Antian Wang, Gan Jiang, Meng Huang, Huan Chen, Yu Qiu, Bin Bo, Shanbao Tong, Rong Shao, Binyin Li, Gang Wang, Hao Wang, Yongbo Hu, Hongzhuan Chen, Xiaoling Gao
Summary: The multifunctional nanostructure RAP-RL developed in this study accelerates Aβ clearance and restores cerebral vasculature function, resulting in improved learning and memory abilities in AD mice.
Article
Oncology
Cheng Chang, Xiaoyan Sun, Gang Wang, Hong Yu, Wenlu Zhao, Yaqiong Ge, Shaofeng Duan, Xiaohua Qian, Rui Wang, Bei Lei, Lihua Wang, Liu Liu, Maomei Ruan, Hui Yan, Ciyi Liu, Jie Chen, Wenhui Xie
Summary: This study developed a machine learning model that combines PET/CT radiomic features and clinical characteristics to predict the ALK rearrangement status in lung adenocarcinomas non-invasively. The model showed a significant advantage in predicting the ALK mutation status compared to the clinical model alone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yong-Bo Hu, Yong-Fang Zhang, Ru-Jing Ren, Eric B. Dammer, Xin-Yi Xie, Shi-Wu Chen, Qiang Huang, Wan-Ying Huang, Rui Zhang, Hong-Zhuan Chen, Hao Wang, Gang Wang
Summary: Different cellular and molecular changes contribute to the pathogenesis of Alzheimer's disease (AD), among which neuron-specific dysregulation is a key event leading to the accumulation of classic pathologies such as amyloid plaques. The decrease of miR-425 in AD brain is associated with the formation of APAM and accelerated disease progression through enhanced downstream mRNA targets. Intervening with miR-425 supplementation in mouse models shows potential for ameliorating APAM changes and memory deficits in AD, providing insights for new treatment strategies.
Article
Clinical Neurology
Ru-Jing Ren, Qiang Huang, Gang Xu, Kai Gu, Eric B. Dammer, Chun-Fang Wang, Xin-Yi Xie, Wen Chen, Zhen-Yi Shao, Sheng-Di Chen, Gang Wang
Summary: The study found that patients with Alzheimer's disease in the Chinese population had a lower risk of developing certain cancers, including lung cancer and prostate and testicular cancer, but a positive association with a higher incident rate of lymphoma was observed.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Qiang Huang, Yong-Fang Zhang, Lin-Jie Li, Eric B. Dammer, Yong-Bo Hu, Xin-Yi Xie, Ran Tang, Jian-Ping Li, Jin-Tao Wang, Xiang-Qian Che, Gang Wang, Ru-Jing Ren
Summary: Neuronal ceroid lipofuscinosis (NCL) is a group of inherited neurodegenerative diseases characterized by the presence of lipofuscin deposits in the lysosomal lumen. In this study, a novel C128Y mutation in the DNAJC5 gene was identified in a young Chinese female with adult-onset NCL, leading to abnormal palmitoylation and lipofuscin deposits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jin-Tao Wang, Gang Xu, Ru-Jing Ren, Ying Wang, Ran Tang, Qiang Huang, Jian-Ping Li, Murad Al-Nusaif, Wei-Dong Le, Gang Wang
Summary: This study investigates the impact of health insurance and resources on the burden of Alzheimer's disease and related dementias (ADRD). The findings suggest that ADRD has an increasing burden on patients globally, both physically and economically. Moreover, health resources are negatively associated with certain burden factors, such as disability-adjusted life years (DALY) and death, but positively associated with years of life lived with disability (YLD).
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Yisong Hu, Wenjia Peng, Rujing Ren, Ying Wang, Gang Wang
Summary: This study found a clear association between sarcopenia and mild cognitive impairment (MCI) among elderly adults in China, based on a large-scale survey. The longitudinal study confirmed the link between sarcopenia and cognitive decline.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Hua-Long Wang, Ran Tang, Ru-Jing Ren, Eric B. Dammer, Qi-Hao Guo, Guo-Ping Peng, Hai-Lun Cui, You-Min Zhang, Jin-Tao Wang, Xin-Yi Xie, Qiang Huang, Jian-Ping Li, Fu-Hua Yan, Sheng-Di Chen, Na-Ying He, Gang Wang
Summary: Language deficits often occur during the early stages of Alzheimer's disease (AD), and the percentage of silence duration (PSD) has been found to be a reliable diagnostic biomarker for early-stage AD and amnestic mild cognitive impairment (aMCI). The brain's response to fluency tasks is significantly inhibited in the aMCI/AD group, which partially explains the elevated PSD.
Article
Biochemistry & Molecular Biology
Xin-Yi Xie, Qian-Hua Zhao, Qiang Huang, Eric Dammer, Sheng-di Chen, Ru-Jing Ren, Gang Wang, Alzheimer's Dis Neuroimaging Initiat
Summary: Compared with early-onset familial Alzheimer's disease, the heritability of most familial late-onset Alzheimer's disease remains unclear. In this study, targeted sequencing of selected candidate genes was conducted for Chinese Han individuals with familial late-onset Alzheimer's disease, revealing the most frequent variants in CR1, TREM2, and ACE. Additionally, novel pathogenic mutations in ACE were found to be associated with familial late-onset Alzheimer's disease.
Article
Medicine, General & Internal
Xiehe Kong, Zhao Ma, Ran Tang, Xuejun Wang, Kai Wei, Guang Yang, Yanting Yang, Yue Zhao, Dan Zhang, Chen Xie, Gang Wang, Xiaopeng Ma
Summary: This study aims to confirm the efficacy of acupuncture as an adjunctive treatment for mild AD and explore the relationship between clinical efficacy and shifts in gut microbiota.
FRONTIERS IN MEDICINE
(2023)
Article
Neurosciences
Xiang-Qian Che, Guo-Zhen Lin, Xiao-Hong Liu, Gang Wang, Qian-Hua Zhao, Ru-Jing Ren
Summary: This study identified a novel SIGMAR1 gene variant independent of C9orf72 gene status, which is associated with semantic dementia. Further MR imaging showed that this variant is related to pathological progression and is predicted to affect normal splicing.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Editorial Material
Clinical Neurology
Yue Huang, Qiao-Xin Li, Ling-Xiao Cao, Gang Wang, Daniel Kam Yin Chan, Conceicao Bettencourt, Adrienne E. Milward
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychiatry
Xinyi Xie, Qingxiang Song, Chengxiang Dai, Shishuang Cui, Ran Tang, Suke Li, Jing Chang, Ping Li, Jintao Wang, Jianping Li, Chao Gao, Hongzhuan Chen, Shengdi Chen, Rujing Ren, Xiaoling Gao, Gang Wang
Summary: This study conducted a phase I/II clinical trial with three dosage groups to explore the safety and efficacy of allogenic human adipose MSCs-Exos in patients with mild to moderate AD. The results showed that intranasal administration of ahaMSCs-Exos was safe and well tolerated, and a specific dosage was recommended for further clinical trials.
GENERAL PSYCHIATRY
(2023)
Review
Health Care Sciences & Services
Ling-Xiao Cao, Gang Wang, Qi-Hao Guo, Wei Zhang, Thomas Bak, Yue Huang
Summary: Addenbrooke's cognitive examination (ACE) is an effective cognitive screening tool that shows better performance than other tests in detecting mild cognitive impairment in various neurological disorders. The Chinese version of ACE has been translated into multiple languages and can facilitate early identification and management of cognitive impairment in China.
Review
Psychiatry
Rujing Ren, Jinlei Qi, Shaohui Lin, Xinya Liu, Peng Yin, Zhihui Wang, Ran Tang, Jintao Wang, Qiang Huang, Jianping Li, Xinyi Xie, Yongbo Hu, Shishuang Cui, Yuan Zhu, Xiaoping Yu, Pengfei Wang, Yikang Zhu, Yiran Wang, Yanyan Huang, Yisong Hu, Ying Wang, Chunbo Li, Maigeng Zhou, Gang Wang
Summary: China's aging population and the increasing prevalence of neurodegenerative disorders, particularly Alzheimer's disease and related dementias, have led to an urgent need for healthcare resources to support the affected individuals and their families. This report provides an overview of the epidemiological trends, economic burden, clinical diagnosis and treatment status, and available public health resources for these diseases in China. It also highlights the public health impact of Alzheimer's disease and related dementias, including prevalence, mortality, costs, and the overall effect on caregivers and society. Furthermore, it offers technical guidance and support for prevention and treatment, and emphasizes the importance of international exchange and cooperation in addressing this issue.
GENERAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
