Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

Graded 6-OHDA-induced dopamine depletion in the nigrostriatal pathway evokes progressive pathological neuronal activities in the subthalamic nucleus of a hemi-parkinsonian mouse

(2018) Sunghee Estelle Park et al.   BEHAVIOURAL BRAIN RESEARCH

Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

(2018) Sarah-Lena Offenburger et al.   PLoS Genetics

Metabolic Disturbances in the Striatum and Substantia Nigra in the Onset and Progression of MPTP-Induced Parkinsonism Model

(2018) Yi Lu et al.   Frontiers in Neuroscience

Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

(2017) Yi-Da Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice

(2017) Nicolas Naudet et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease

(2017) Qi Xu et al.   JOURNAL OF NUTRITION

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Cerium oxide nanoparticles could ameliorate behavioral and neurochemical impairments in 6-hydroxydopamine induced Parkinson's disease in rats

(2017) Maha A. Hegazy et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement

(2017) XiaoLong Hu et al.   NEUROPHARMACOLOGY

Triggering of inflammasome by impaired autophagy in response to acute experimental Parkinson’s disease

(2017) Sabrina Giacoppo et al.   NEUROREPORT

Coenzyme Q10 Prevents Mitochondrial Dysfunction and Facilitates Pharmacological Activity of Atorvastatin in 6-OHDA Induced Dopaminergic Toxicity in Rats

(2017) Santosh Kumar Prajapati et al.   NEUROTOXICITY RESEARCH

Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss

(2017) Gelareh Alam et al.   NEUROTOXICOLOGY

AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson’s Disease

(2017) Adeline H. Basil et al.   Frontiers in Cellular Neuroscience

Pilot study: molecular risk factors for diagnosing sporadic Parkinson's disease based on gene expression in blood in MPTP-induced rhesus monkeys

(2017) Liangqin Shi et al.   Oncotarget

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models

(2016) Šárka Lehtonen et al.   ANTIOXIDANTS & REDOX SIGNALING

Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models

(2016) Gabor Maasz et al.   Disease Models & Mechanisms

Unexpected Neuroprotective Effects of Loganin on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurotoxicity and Cell Death in Zebrafish

(2016) Li Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease

(2016) Chien-Wei Feng et al.   Marine Drugs

Oral r-(-)-11-o-valeryl-n-n-propylnoraporphine reverses motor deficits in mptp-treated marmosets

(2016) Louise Lincoln et al.   MOVEMENT DISORDERS

Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence

(2016) Carmen Avagliano et al.   PHARMACOLOGICAL RESEARCH

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease in zebrafish

(2016) Nukala Sarath Babu et al.   PROTEOMICS

Inhibitory effect of thiacremonone on MPTP-induced dopaminergic neurodegeneration through inhibition of p38 activation

(2016) Chul Ju Hwang et al.   Oncotarget

Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

(2016) Richard Jay Smeyne et al.   PLoS One

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats

(2015) Andrea Ferrigno et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism

(2015) Ching-Chi Chiu et al.   EXPERIMENTAL NEUROLOGY

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease

(2015) Yupin Chen et al.   Molecular Neurodegeneration

Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson’s disease

(2015) S.R. Jahromi et al.   NEUROSCIENCE

Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae

(2015) Sarah J. Stednitz et al.   NEUROTOXICOLOGY AND TERATOLOGY

The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats

(2014) Yuxin Ma et al.   BEHAVIOURAL BRAIN RESEARCH

Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease

(2014) Krithika Muthukumaran et al.   BMC NEUROSCIENCE

A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson׳s disease

(2014) Scott J. Varga et al.   BRAIN RESEARCH

Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson׳s disease

(2014) Anil Kachroo et al.   BRAIN RESEARCH

Inhibition of Neuronal Cell Mitochondrial Complex I with Rotenone Increases Lipid β-Oxidation, Supporting Acetyl-Coenzyme A Levels

(2014) Andrew J. Worth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Expression of Organic Cation Transporters, Oct1 and Oct2, in Brain Microvessels and its Implication to MPTP-Induced Dopaminergic Toxicity in Aged Mice

(2014) Kuo-Chen Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

A mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes

(2014) Arvind K. Shukla et al.   NEUROBIOLOGY OF AGING

Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans

(2014) Claudia P. González-Hunt et al.   PLoS One

Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae

(2014) Chien-Wei Feng et al.   Zebrafish

The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease

(2013) Xian-Si Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease

(2013) G Drui et al.   MOLECULAR PSYCHIATRY

Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish

(2013) Cheong-Meng Chong et al.   NEUROSCIENCE LETTERS

Activation of GSK-3β and Caspase-3 Occurs in Nigral Dopamine Neurons during the Development of Apoptosis Activated by a Striatal Injection of 6-Hydroxydopamine

(2013) Daniel Hernandez-Baltazar et al.   PLoS One

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Animal models of Parkinson’s disease

(2012) Fabio Blandini et al.   FEBS Journal

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

(2012) Peizhou Jiang et al.   NEUROBIOLOGY OF AGING

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

(2012) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

A tale on animal models of Parkinson's disease

(2011) Erwan Bezard et al.   MOVEMENT DISORDERS

Structural Properties of the Caenorhabditis elegans Neuronal Network

(2011) Lav R. Varshney et al.   PLoS Computational Biology

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis

(2010) Mireia Niso-Santano et al.   FREE RADICAL BIOLOGY AND MEDICINE

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

(2009) Claire Gibrat et al.   JOURNAL OF NEUROCHEMISTRY

Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys

(2009) Alison L. McCormack et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism

(2009) Glenda Halliday et al.   MOVEMENT DISORDERS

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation

(2008) Jun Peng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

(2008) Daniel Alvarez-Fischer et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

The 6-hydroxydopamine model: News from the past

(2008) Fabio Blandini et al.   PARKINSONISM & RELATED DISORDERS

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments

(2007) Paulien G.M. Ravenstijn et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS