Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

(2022) Julia TCW et al.   CELL

Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells

(2022) Zhenqing Liu et al.   STEM CELLS

Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimer’s disease risk

(2022) Jin Ma et al.   Frontiers in Neuroscience

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

(2022) Joel W. Blanchard et al.   NATURE

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

(2021) Cheng Wang et al.   Cell Stem Cell

Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging

(2021) Peng Deng et al.   Cell Stem Cell

Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure

(2021) Xianwei Chen et al.   Advanced Science

Dissecting the complexities of Alzheimer disease with in vitro models of the human brain

(2021) Joel W. Blanchard et al.   Nature Reviews Neurology

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

(2020) Shun-Fat Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte-derived clusterin suppresses amyloid formation in vivo

(2020) Aleksandra M. Wojtas et al.   Molecular Neurodegeneration

TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

(2020) Mauro Montalbano et al.   NEUROBIOLOGY OF DISEASE

Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation

(2020) Aleksandra M. Wojtas et al.   Acta Neuropathologica Communications

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons

(2019) Andrés A. Morera et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Intracellular and secreted forms of clusterin are elevated early in Alzheimer's disease and associate with both Aβ and tau pathology

(2019) Claire E. Shepherd et al.   NEUROBIOLOGY OF AGING

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

(2018) Emile S. Pinarbasi et al.   Scientific Reports

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease

(2018) Li Li et al.   Cell Stem Cell

Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression

(2017) Biswajit Padhy et al.   HUMAN MOLECULAR GENETICS

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

(2017) Marc Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

(2017) Douglas C. Dean et al.   JAMA Neurology

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

(2016) Seonjoo Lee et al.   ANNALS OF NEUROLOGY

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

The multifaceted role of astrocytes in regulating myelination

(2016) Hülya Kıray et al.   EXPERIMENTAL NEUROLOGY

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

(2016) Qi Cui et al.   Nature Communications

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency

(2015) Lorenz Studer et al.   Cell Stem Cell

Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells

(2015) Panagiotis Douvaras et al.   Nature Protocols

White matter hyperintensities, cognitive impairment and dementia: an update

(2015) Niels D. Prins et al.   Nature Reviews Neurology

Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

(2015) Shobana Sekar et al.   NEUROBIOLOGY OF AGING

White Matter Degeneration in Atypical Alzheimer Disease

(2015) Francesca Caso et al.   RADIOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microgliain vitro

(2014) Sandra D. Mulder et al.   GLIA

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

(2014) Emily Mills Ko et al.   Journal of Neuroinflammation

Combined Effects of Alzheimer Risk Variants in the CLU and ApoE Genes on Ventricular Expansion Patterns in the Elderly

(2014) F. F. Roussotte et al.   JOURNAL OF NEUROSCIENCE

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

(2014) Panagiotis Douvaras et al.   Stem Cell Reports

Staging TDP-43 pathology in Alzheimer’s disease

(2013) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

(2013) Henna Martiskainen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

What are lipoproteins doing in the brain?

(2013) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Astrocytes: Emerging stars in leukodystrophy pathogenesis

(2013) Angela Lanciotti et al.   Translational Neuroscience

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease

(2013) Douglas C. Dean et al.   JAMA Neurology

Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages

(2012) Young-Jun Shim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

(2012) Gwendolyn Behrendt et al.   GLIA

A culture system to study oligodendrocyte myelination processes using engineered nanofibers

(2012) Seonok Lee et al.   NATURE METHODS

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

(2012) M. Allen et al.   NEUROLOGY

Functional Duality of Astrocytes in Myelination

(2011) B. Nash et al.   JOURNAL OF NEUROSCIENCE

Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults

(2011) M. N. Braskie et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing

(2011) M Szymanski et al.   Translational Psychiatry

Clusterin synergizes with IL-2 for the expansion and IFN-γ production of natural killer cells

(2010) Chung Hee Sonn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease

(2010) Brian T. Gold et al.   NEUROIMAGE

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment

(2009) Orestes Vicente Forlenza et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal

(2009) Qiuhao Qu et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Alzheimer's disease as homeostatic responses to age-related myelin breakdown

(2009) George Bartzokis   NEUROBIOLOGY OF AGING

Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: Their relation to AD common pathology

(2009) Ai Kadokura et al.   NEUROPATHOLOGY

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE