Astrocytes: Emerging stars in leukodystrophy pathogenesis

Adaptive autophagy in Alexander disease-affected astrocytes

(2014) Guomei Tang et al.   Autophagy

Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease

(2013) Marianna Bugiani et al.   BRAIN

Extensive loss of connexins in Baló’s disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte–oligodendrocyte/myelin interaction

(2012) Katsuhisa Masaki et al.   ACTA NEUROPATHOLOGICA

Astroglial Excitability and Gliotransmission: An Appraisal of Ca2+ as a Signalling Route

(2012) Robert Zorec et al.   ASN Neuro

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Connexin-based intercellular communication and astrocyte heterogeneity

(2012) Martin Theis et al.   BRAIN RESEARCH

Human Neural Stem Cells Genetically Modified to Express Human Nerve Growth Factor (NGF) Gene Restore Cognition in the Mouse with Ibotenic Acid-Induced Cognitive Dysfunction

(2012) Hong J. Lee et al.   CELL TRANSPLANTATION

Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia

(2012) Richard Kovács et al.   EPILEPSIA

Direct reprogramming of human astrocytes into neural stem cells and neurons

(2012) Stefania Corti et al.   EXPERIMENTAL CELL RESEARCH

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

Astrocyte calcium signaling and epilepsy

(2012) Giorgio Carmignoto et al.   GLIA

Astrocytic regulation of glutamate homeostasis in epilepsy

(2012) Douglas A. Coulter et al.   GLIA

Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations

(2012) Angela Lanciotti et al.   HUMAN MOLECULAR GENETICS

Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies

(2012) Julien Ratelade et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Brain water channel proteins in health and disease

(2012) Oana Benga et al.   MOLECULAR ASPECTS OF MEDICINE

GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a ClC-2 Cl− Channel Auxiliary Subunit

(2012) Elena Jeworutzki et al.   NEURON

Developmental Splicing Deregulation in Leukodystrophies Related to EIF2B Mutations

(2012) Aurélia Huyghe et al.   PLoS One

Glial Progenitor Cell-Based Treatment and Modeling of Neurological Disease

(2012) S. A. Goldman et al.   SCIENCE

The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes

(2012) Valéry Combes et al.   TRENDS IN PARASITOLOGY

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

(2012) Tarja A Juopperi et al.   Molecular Brain

Homeostatic function of astrocytes: Ca2+ and Na+ signalling

(2012) Vladimir Parpura et al.   Translational Neuroscience

Mutant GlialCAM Causes Megalencephalic Leukoencephalopathy with Subcortical Cysts, Benign Familial Macrocephaly, and Macrocephaly with Retardation and Autism

(2011) Tania López-Hernández et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter

(2011) Michal Geva et al.   BRAIN

Megalencephalic leucoencephalopathy with cysts: defect in chloride currents and cell volume regulation

(2011) Margreet C. Ridder et al.   BRAIN

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

(2011) K Gupta et al.   CELL DEATH AND DIFFERENTIATION

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Morphofunctional Aspects of the Blood-Brain Barrier

(2011) Beatrice Nico et al.   CURRENT DRUG METABOLISM

Role of aquaporins in cell migration and edema formation in human brain tumors

(2011) Beatrice Nico et al.   EXPERIMENTAL CELL RESEARCH

Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury

(2011) Soo Ryeong Jeong et al.   EXPERIMENTAL NEUROLOGY

Childhood leukodystrophies: a clinical perspective

(2011) Alfried Kohlschütter et al.   Expert Review of Neurotherapeutics

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal-Astrocyte Metabolic Interactions: Understanding the Transition Into Abnormal Astrocytoma Metabolism

(2011) Dennis A. Turner et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Functional Duality of Astrocytes in Myelination

(2011) B. Nash et al.   JOURNAL OF NEUROSCIENCE

Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell–derived astrocytes in a rat spinal cord injury model

(2011) Koichi Hayashi et al.   JOURNAL OF NEUROSURGERY-SPINE

Transplantation of Human Glial Restricted Progenitors and Derived Astrocytes into a Contusion Model of Spinal Cord Injury

(2011) Ying Jin et al.   JOURNAL OF NEUROTRAUMA

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Knockdown of MLC1 in primary astrocytes causes cell vacuolation: A MLC disease cell model

(2011) Anna Duarri et al.   NEUROBIOLOGY OF DISEASE

Autism with Seizures and Intellectual Disability: Possible Causative Role of Gain-of-function of the Inwardly-Rectifying K+ Channel Kir4.1

(2011) Federico Sicca et al.   NEUROBIOLOGY OF DISEASE

Role of Astrocytes in Neurovascular Coupling

(2011) Gabor C. Petzold et al.   NEURON

Clinical aspects and pathology of Alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation

(2011) Tomokatsu Yoshida et al.   NEUROPATHOLOGY

The role of gap junctions in the brain in health and disease

(2011) Ekrem Dere et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Precursor Cell Biology and the Development of Astrocyte Transplantation Therapies: Lessons from Spinal Cord Injury

(2011) Mark Noble et al.   Neurotherapeutics

Transplantation of Specific Human Astrocytes Promotes Functional Recovery after Spinal Cord Injury

(2011) Stephen J. A. Davies et al.   PLoS One

Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS

(2011) Angelo C. Lepore et al.   PLoS One

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

(2011) V. Benfenati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gap Junction Disorders of Myelinating Cells

(2011) Kleopas A. Kleopa et al.   REVIEWS IN THE NEUROSCIENCES

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Pathologic and Phenotypic Alterations in a Mouse Expressing a Connexin47 Missense Mutation That Causes Pelizaeus-Merzbacher–Like Disease in Humans

(2011) Oliver Tress et al.   PLoS Genetics

Aquaporin-4 astrocytopathy in Baló’s disease

(2010) Takeshi Matsuoka et al.   ACTA NEUROPATHOLOGICA

Recent advances in (patho)physiology of astroglia

(2010) Alexei Verkhratsky et al.   ACTA PHARMACOLOGICA SINICA

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Molecular and cellular mechanisms of excitotoxic neuronal death

(2010) Yan Wang et al.   APOPTOSIS

The β1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis

(2010) Maria S. Brignone et al.   HUMAN MOLECULAR GENETICS

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition

(2010) Guomei Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain Ion and Amino Acid Contents During Edema Development in Hepatic Encephalopathy

(2010) Wojciech Hilgier et al.   JOURNAL OF NEUROCHEMISTRY

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

(2010) Rujin Tian et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Leukoencephalopathy With Vanishing White Matter: A Review

(2010) Marianna Bugiani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Defective Glial Maturation in Vanishing White Matter Disease

(2010) Marianna Bugiani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Altered glial–neuronal crosstalk: Cornerstone in the pathogenesis of hepatic encephalopathy

(2010) Roger F. Butterworth   NEUROCHEMISTRY INTERNATIONAL

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Functions of astrocytes and their potential as therapeutic targets

(2010) Harold K. Kimelberg et al.   Neurotherapeutics

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery

(2010) Annelies Van Dycke et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Leukodystrophies and other genetic metabolic leukoencephalopathies in children and adults

(2009) Alfried Kohlschütter et al.   BRAIN & DEVELOPMENT

Astrocytic dysfunction: Insights on the role in neurodegeneration

(2009) Daniela Rossi et al.   BRAIN RESEARCH BULLETIN

The contribution of astrocyte signalling to neurovascular coupling

(2009) Giorgio Carmignoto et al.   BRAIN RESEARCH REVIEWS

Loss of astrocytic glutamate transporters in Wernicke encephalopathy

(2009) Alan S. Hazell et al.   GLIA

Suppression of GFAP toxicity by αB-crystallin in mouse models of Alexander disease

(2009) Tracy L. Hagemann et al.   HUMAN MOLECULAR GENETICS

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

(2009) Jun-Ping Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

MLC1 trafficking and membrane expression in astrocytes: Role of caveolin-1 and phosphorylation

(2009) Angela Lanciotti et al.   NEUROBIOLOGY OF DISEASE

Astrocytes are a major target in thiamine deficiency and Wernicke's encephalopathy

(2009) Alan S. Hazell   NEUROCHEMISTRY INTERNATIONAL

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Congenital and Evolving Vascular Disorders Associated with Cutaneous Hemangiomas: Case Report

(2009) I. Pascual-Castroviejo et al.   NEUROPEDIATRICS

Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter

(2009) J. Patrick van der Voorn et al.   NEURORADIOLOGY

Neurological autoimmunity targeting aquaporin-4

(2009) S.R. Hinson et al.   NEUROSCIENCE

Astrocytes and the regulation of cerebral blood flow

(2009) Raymond C. Koehler et al.   TRENDS IN NEUROSCIENCES

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Antibody to aquaporin-4 in the long-term course of neuromyelitis optica

(2008) S. Jarius et al.   BRAIN

Genes involved in leukodystrophies: A glance at glial functions

(2008) Odile Boespflug-Tanguy et al.   Current Neurology and Neuroscience Reports

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice

(2008) Woosung Cho et al.   EXPERIMENTAL CELL RESEARCH

Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axonsin vitro

(2008) Annette Sorensen et al.   GLIA

Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects

(2008) A. Duarri et al.   HUMAN MOLECULAR GENETICS

Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons

(2008) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Targeted Activation of Astrocytes: A Potential Neuroprotective Strategy

(2008) Carole Escartin et al.   MOLECULAR NEUROBIOLOGY

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Memory Processing in the Avian Hippocampus Involves Interactions between β-Adrenoceptors, Glutamate Receptors and Metabolism

(2008) Marie E Gibbs et al.   NEUROPSYCHOPHARMACOLOGY

A Point Mutation in Translation Initiation Factor 2B Leads to a Continuous Hyper Stress State in Oligodendroglial-Derived Cells

(2008) Liraz Kantor et al.   PLoS One

Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex

(2008) J. Schummers et al.   SCIENCE

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

(2007) Jacques De Keyser et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Biochemical characterization of MLC1 protein in astrocytes and its association with the dystrophin–glycoprotein complex

(2007) Elena Ambrosini et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mechanisms of glutamate release from astrocytes

(2007) Erik B. Malarkey et al.   NEUROCHEMISTRY INTERNATIONAL