An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Genetically engineered nano‐melittin vesicles for multimodal synergetic cancer therapy

(2023) Jianzhong Zhang et al.   Bioengineering & Translational Medicine

Melittin treatment prevents colorectal cancer from progressing in mice through ER stress-mediated apoptosis

(2023) Yan Luo et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

(2022) Ayşegül Varol et al.   Toxin Reviews

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Therapeutic Effect of Melittin–dKLA Targeting Tumor-Associated Macrophages in Melanoma

(2022) Ik-Hwan Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

(2022) Yonghui Lv et al.   Toxins

Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer

(2022) Mohamed A. Alfaleh et al.   Scientific Reports

The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer

(2022) Pelin Erkoc et al.   Toxins

Melittin sensitizes skin squamous carcinoma cells to 5‐fluorouracil by affecting cell proliferation and survival

(2021) Alicia S. Ombredane et al.   EXPERIMENTAL DERMATOLOGY

Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates

(2021) Shaimaa M. Badr-Eldin et al.   Frontiers in Pharmacology

Melittin, a honeybee venom derived peptide for the treatment of chemotherapy-induced peripheral neuropathy

(2021) Tenzin Tender et al.   MEDICAL ONCOLOGY

The Cytotoxic Effect of Apis mellifera Venom with a Synergistic Potential of Its Two Main Components—Melittin and PLA2—On Colon Cancer HCT116 Cell Lines

(2021) Carole Yaacoub et al.   MOLECULES

Applications and evolution of melittin, the quintessential membrane active peptide

(2021) Shantanu Guha et al.   BIOCHEMICAL PHARMACOLOGY

Melittin inhibits the expression of key genes involved in tumor microenvironment formation by suppressing HIF-1α signaling in breast cancer cells

(2021) Zabih Mir Hassani et al.   MEDICAL ONCOLOGY

Hyaluronic Acid Coating Reduces the Leakage of Melittin Encapsulated in Liposomes and Increases Targeted Delivery to Melanoma Cells

(2021) Yanyan Li et al.   Pharmaceutics

Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

(2021) Farnaz Dabbagh Moghaddam et al.   Cancer Nanotechnology

In vivo and invitro experimentation for scientific validation of the traditional use of Chromolaena odorata (L.) against envenomation of honey bee sting

(2021) Tania S. Das et al.   Advances in Traditional Medicine

Stable Loading and Delivery of Melittin with Lipid-Coated Polymeric Nanoparticles for Effective Tumor Therapy with Negligible Systemic Toxicity

(2021) Ran Ye et al.   ACS Applied Materials & Interfaces

Development of D-melittin polymeric nanoparticles for anti-cancer treatment

(2021) Shixian Lv et al.   BIOMATERIALS

Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells

(2021) Ghada H. Mansour et al.   BIOORGANIC CHEMISTRY

In Vitro and In Vivo Investigation of the Radiation-Sensitizing Effects of Melittin in Breast Cancer Cells

(2021) Seo-Na Chang et al.   International Journal of Peptide Research and Therapeutics

Apoptotic Effects of Melittin on 4T1 Breast Cancer Cell Line is Associated with Up Regulation of Mfn1 and Drp1 mRNA Expression

(2020) Farnaz D. Moghaddam et al.   Anti-Cancer Agents in Medicinal Chemistry

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response

(2020) Xiang Yu et al.   Nature Communications

Apitoxin and Its Components against Cancer, Neurodegeneration and Rheumatoid Arthritis: Limitations and Possibilities

(2020) Andreas Aufschnaiter et al.   Toxins

Melittin—A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukaemia Cells

(2020) Michal Ceremuga et al.   Biomolecules

Melittin from Apis florea Venom as a Promising Therapeutic Agent for Skin Cancer Treatment

(2020) Sirikwan Sangboonruang et al.   Antibiotics-Basel

Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer

(2020) Ciara Duffy et al.   npj Precision Oncology

Smart aptamer-modified calcium carbonate nanoparticles for controlled release and targeted delivery of epirubicin and melittin into cancer cells in vitro and in vivo

(2019) Rezvan Yazdian-Robati et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Melittin: from honeybees to superbugs

(2019) Hamed Memariani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

(2019) Chanju Lee et al.   Journal for ImmunoTherapy of Cancer

Synergistic Effects of Melittin and Plasma Treatment: A Promising Approach for Cancer Therapy

(2019) Priyanka Shaw et al.   Cancers

Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells

(2019) Jinxia Qi et al.   NANOTECHNOLOGY

The membrane effects of melittin on gastric and colorectal cancer

(2019) Caroline Soliman et al.   PLoS One

Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines

(2019) Danijela D. Nikodijević et al.   Toxin Reviews

Use of Selected Carbon Nanoparticles as Melittin Carriers for MCF-7 and MDA-MB-231 Human Breast Cancer Cells

(2019) Karolina Daniluk et al.   Materials

Anti-Tumor Effects of Melittin and Its Potential Applications in Clinic

(2018) Can Lyu et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer

(2018) Seyed Hossein Rajabnejad et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells

(2018) Mengyun Ke et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bee venom therapy: Potential mechanisms and therapeutic applications

(2018) Shuai Zhang et al.   TOXICON

Helical Structure of Recombinant Melittin

(2018) Lisa S. Ramirez et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Synergistic co-delivery of doxorubicin and melittin using functionalized magnetic nanoparticles for cancer treatment: loading and in vitro release study by LC–MS/MS

(2018) Marjan Hematyar et al.   Artificial Cells Nanomedicine and Biotechnology

Towards prostate cancer gene therapy: Development of a chlorotoxin-targeted nanovector for toxic (melittin) gene delivery

(2017) Zahra Tarokh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line

(2017) Hannaneh Zarrinnahad et al.   International Journal of Peptide Research and Therapeutics

A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety

(2017) Jie Mao et al.   Journal of Hematology & Oncology

Melittin exerts an antitumor effect on non-small cell lung cancer cells

(2017) Su-Fang Zhang et al.   Molecular Medicine Reports

Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model

(2017) Chanju Lee et al.   Oncotarget

Polypeptide-Grafted Nanodiamonds for Controlled Release of Melittin to Treat Breast Cancer

(2017) Haiwang Lai et al.   ACS Macro Letters

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

(2016) Mingjun Liu et al.   Journal of Translational Medicine

Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects

(2016) Gihyun Lee et al.   MOLECULES

Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity

(2016) Meong Cheol Shin et al.   PHARMACEUTICAL RESEARCH

Melittin induces human gastric cancer cell apoptosisviaactivation of mitochondrial pathway

(2016) Gui-Mei Kong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Melittin inhibits the invasion of MCF-7 cells by downregulating CD147 and MMP-9 expression

(2016) Jianjun Wang et al.   Oncology Letters

First report on the isolation of melittin from Iranian honey bee venom and evaluation of its toxicity on gastric cancer AGS cells

(2015) Amir Mahmoodzadeh et al.   Journal of the Chinese Medical Association

Expression and purification of recombinant ATF-mellitin, a new type fusion protein targeting ovarian cancer cells, in P. pastoris

(2015) MANMAN SU et al.   ONCOLOGY REPORTS

Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells

(2015) Xiaoqin Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dual secured nano-melittin for the safe and effective eradication of cancer cells

(2015) Bei Cheng et al.   Journal of Materials Chemistry B

Biotoxins for Cancer Therapy

(2014) Cui-Cui Liu et al.   Asian Pacific Journal of Cancer Prevention

Melittin suppresses EGF-induced cell motility and invasion by inhibiting PI3K/Akt/mTOR signaling pathway in breast cancer cells

(2014) Yun-Jeong Jeong et al.   FOOD AND CHEMICAL TOXICOLOGY

Expression and anticancer activity analysis of recombinant human uPA1–43-melittin

(2014) MANMAN SU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Functional characterization of naturally occurring melittin peptide isoforms in two honey bee species, Apis mellifera and Apis cerana

(2014) Doori Park et al.   PEPTIDES

Melittin Restores PTEN Expression by Down-Regulating HDAC2 in Human Hepatocelluar Carcinoma HepG2 Cells

(2014) Hui Zhang et al.   PLoS One

High-level expression, purification and study of bioactivity of fusion protein M-IL-2(88Arg, 125Ala) in Pichia pastoris

(2014) Lin Li et al.   PROTEIN EXPRESSION AND PURIFICATION

Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α

(2014) Xi Yang et al.   TUMOR BIOLOGY

Hybrid Melittin Cytolytic Peptide-Driven Ultrasmall Lipid Nanoparticles Block Melanoma Growth in Vivo

(2013) Chuan Huang et al.   ACS Nano

A novel melittin-MhIL-2 fusion protein inhibits the growth of human ovarian cancer SKOV3 cells in vitro and in vivo tumor growth

(2013) Mingjun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Construction and Characterization of a CTLA-4-Targeted scFv–Melittin Fusion Protein as a Potential Immunosuppressive Agent for Organ Transplant

(2013) Hailong Jin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease

(2013) Yu Wang et al.   Chinese Journal of Integrative Medicine

Inhibitory Effect of Biosynthetic Nanoscale Peptide Melittin on Hepatocellular Carcinoma, Driven by Survivin Promoter

(2013) Lili Qu et al.   Journal of Biomedical Nanotechnology

Enhanced binding to and killing of hepatocellular carcinoma cellsin vitroby melittin when linked with a novel targeting peptide screened from phage display

(2013) Honglei Zhao et al.   JOURNAL OF PEPTIDE SCIENCE

Cytotoxicity of melittin and apamin in human hepatic L02 and HepG2 cellsin vitro

(2013) Jinhui Zhou et al.   Toxin Reviews

Construction and expression of sTRAIL–melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli

(2012) Hongyan Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway

(2011) Miran Jo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB

(2010) Mi Hee Park et al.   PROSTATE

Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level

(2009) Enrique Barrajón-Catalán et al.   CANCER LETTERS

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

(2009) Neelesh R. Soman et al.   JOURNAL OF CLINICAL INVESTIGATION

Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway

(2008) Shujing Liu et al.   HEPATOLOGY

Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol

(2007) Sam Maher et al.   BIOCHEMICAL PHARMACOLOGY