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Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

Journal

TOXIN REVIEWS
Volume 41, Issue 4, Pages 1382-1395

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/15569543.2021.2024576

Keywords

Apitherapy; anti-inflammatory drugs; bee venom; cancer; melittin

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Bee venom therapy is a traditional approach to curing various medical conditions and also shows promising potential for treating multiple types of cancers. Researchers focus on understanding the molecular activity mechanisms and cellular targets of bee venom, as well as utilizing cutting-edge nanotechnological advances to overcome challenges and exploring its anticancer application in clinical settings.
Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ovary, stomach, kidney, prostate, cervical, colon and esophageal cancers, osteosarcoma, leukemia, melanoma and hepatocellular carcinoma. We therefore focused not only on the molecular activity mechanisms and cellular targets of bee venom and its components, but also on modern solutions as cutting-edge nanotechnological advances to overcome existing bottlenecks, and the latest advances in the anticancer application of bee venom in clinical settings.

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