Review
Oncology
Agata Malek, Maciej Strzemski, Joanna Kurzepa, Jacek Kurzepa
Summary: This paper presents the current state of knowledge regarding the mechanisms of anticancer activity of bee venom, showing its strong potential in inducing apoptosis and inhibiting the cell cycle of tumor cells without affecting normal cells significantly. Animal studies also support the safety of venom doses effective in vitro. This information is valuable for planning future clinical trials.
Review
Food Science & Technology
Jasmin Katrin Badawi
Summary: Prostate cancer is one of the most common cancers in men, with challenges in disease progression and resistance of cancer cells to available therapeutic agents. Further therapeutic agents are needed, and bee venom components have shown promising anticancer effects, particularly melittin.
Article
Food Science & Technology
Seongjae Bae, Hyemin Gu, Mi-Gyeong Gwon, Hyun-Jin An, Sang-Mi Han, Sun-Jae Lee, Jaechan Leem, Kwan-Kyu Park
Summary: Bee venom and melittin can alleviate skin infections caused by Streptococcus pyogenes and have anti-inflammatory effects.
Review
Food Science & Technology
Na-Yoen Kwon, Soo-Hyun Sung, Hyun-Kyung Sung, Jang-Kyung Park
Summary: Bee venom and its components have been found to have anticancer effects on breast cancer cells by reducing cell numbers and improving survival rates. The various mechanisms of action suggest the potential for reducing side effects and the future prevention and treatment of breast cancer.
Article
Biochemistry & Molecular Biology
Ghada H. Mansour, Mohammed A. El-Magd, Dalia H. Mahfouz, Ismail A. Abdelhamid, Magda F. Mohamed, Nada S. Ibrahim, Abdel Hady A. Abdel Wahab, Emad M. Elzayat
Summary: The study found that Bee Venom and its active component, Melittin, when combined with Sorafenib, have a synergistic anticancer effect on HepG2 cells, potentially representing a new enhancing strategy for HCC treatment.
BIOORGANIC CHEMISTRY
(2021)
Review
Food Science & Technology
Aida A. Abd El-Wahed, Shaden A. M. Khalifa, Mohamed H. Elashal, Syed G. Musharraf, Aamer Saeed, Alfi Khatib, Haroon Elrasheid Tahir, Xiaobo Zou, Yahya Al Naggar, Arshad Mehmood, Kai Wang, Hesham R. El-Seedi
Summary: Bee venom is widely used in skin care products to treat various skin diseases, but safety concerns exist due to potential allergic reactions. Studies have shown that adverse reactions to bee venom can lead to excessive immune responses, including anaphylaxis, which typically resolve over time.
Article
Biochemistry & Molecular Biology
Hafsa Er-Rouassi, Meryem Bakour, Soumaya Touzani, Miguel Vilas-Boas, Soraia Falcao, Catherine Vidal, Badiaa Lyoussi
Summary: This study evaluated the potential effect of bee venom and its major components on a mouse model of peripheral nerve injury. The results showed that bee venom treatment was more effective for behavioral recovery. After 4 weeks, the facial motoneurons in the BV-treated group showed normal labeling, while no such restoration was observed in the other groups.
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Minhaj Ahmad Khan, Rajnish Kumar, Tarun Kumar Upadhyay
Summary: Apitherapy using bee products, especially honeybee venom, has gained recognition globally in cancer therapeutics. Bee products, including honeybee venom, have shown significant potential in strengthening the immune system and improving human health.
Article
Biology
Ivan Koludarov, Mariana Velasque, Tobias Senoner, Thomas Timm, Carola Greve, Alexander Ben Hamadou, Deepak Kumar Gupta, Guenter Lochnit, Michael Heinzinger, Andreas Vilcinskas, Rosalyn Gloag, Brock A. Harpur, Lars Podsiadlowski, Burkhard Rost, Timothy N. W. Jackson, Sebastien Dutertre, Eckart Stolle, Bjoern M. von Reumont
Summary: Most venom genes in Hymenoptera are shared by all members of the clade, with single gene co-option being the primary source and gene duplication contributing to diversification. Only a few venom proteins, such as melittin and anthophilin1, appear to be unique to the bee lineage, suggesting that most venom proteins predate the evolution of the aculeate stinger and the mega-radiation of hymenopterans.
Article
Multidisciplinary Sciences
Naiqi Shi, Tibor G. Szanto, Jia He, Christina I. Schroeder, Andrew A. Walker, Jennifer R. Deuis, Irina Vetter, Gyoergy Panyi, Glenn F. King, Samuel D. Robinson
Summary: Most bee species have the ability to sting humans, causing painful reactions. This study investigates the venom composition of the Australian great carpenter bee and finds that it is similar to the venoms of other social bee species. The venom can directly activate mammalian sensory neurons and induce pain behaviors.
SCIENTIFIC REPORTS
(2022)
Article
Entomology
Hyun Seok Yun, Jisun Oh, Ji Sun Lim, Hyo Jung Kim, Jong-Sang Kim
Summary: This study compared the anti-inflammatory effects of wasp venom from the yellow-legged hornet (Vespa velutina) with bee venom on BV-2 murine microglial cells. The results showed that wasp venom effectively suppressed LPS-induced inflammation in microglial cells by inhibiting the NF-kappa B-mediated signaling pathway.
Article
Multidisciplinary Sciences
Asli Elif Tanugur-Samanc, Meral Kekecoglu
Summary: This research paper aimed to determine the characteristics of Anatolian bee venom through analyzing its chemical content and microbiological properties. The results showed that Anatolian bee venom has a high phospholipase A2 content, similar levels of apamin compared to other countries, and melittin content within standard values. The bee venom samples exhibited high sugar content and minimal microbial development, with no Staphylococcus aureus detected.
Article
Food Science & Technology
Karolina Bodlakova, Jan Cerny, Helena Sterbova, Roman Guran, Ondrej Zitka, Dalibor Kodrik
Summary: This study investigated the physiological responses of American cockroaches to honeybee venom. The results showed that bee venom caused severe stress and destruction of muscle cell ultrastructure in the cockroaches. The venom also regulated the levels of substances in the cockroaches' haemolymph and the activity of digestive enzymes. Furthermore, it significantly reduced vitellogenin levels in female cockroaches and had an impact on dopamine and glutathione levels.
Review
Pharmacology & Pharmacy
Peiying Shi, Shihui Xie, Jiali Yang, Yi Zhang, Shuo Han, Songkun Su, Hong Yao
Summary: This study reviewed the recent progress in the pharmacological effects and mechanisms of bee venom (BV) and its main components against various diseases. It identified the target proteins and signaling pathways involved, and bioinformatically predicted the potential effects and mechanisms on diseases. The review provides new insights into the therapeutic effects of BV and its main components.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anqi Wang, Yuan Zheng, Wanxin Zhu, Liuxin Yang, Yang Yang, Jinliang Peng
Summary: This review discusses recent advances in nano-delivery systems of MEL, as well as MEL-modified nano drug carriers for cancer therapy.
